第二信使

通过G蛋白偶联的膜受体指导第二信使反应，再通过DNA结合蛋白，调节基因表达产生效应；

Effects mediated by membrane receptors that are coupled with second messenger systems ;

交联膜CD23分子对B淋巴细胞增殖及细胞内第二信使物质的影响

Cross & linking Membranous CD23 Molecules on B Lymphocytes Affect Its Proliferation and Second Messenger

第二信使cAMP产生过程的数学模型

The mathematical model simulating second messenger cAMP production

蛋白激酶C家族作为第二信使在多条信号通路中发挥着重要作用，具有广泛的生物学效应。

As one of the second messengers , protein kinase C ( PKC ) plays important roles in cellular signaling pathways and has broad biological activities .

cAMP作为第二信使是ADM作用过程中的主要因子。

CAMP has been found to be the second messenger in the majority of ADM actions .

细胞内过量的ROS可作为第二信使触发凋亡信号，从而通过调节细胞凋亡相关基因的表达和核转录因子的活化，使细胞发生凋亡。

Excess intracellular ROS could serve as a second messenger to trigger apoptosis signal .

钙离子（Calcium，Ca2+）作为动植物细胞内重要的第二信使，参与细胞内众多的生理反应。

As an important second messenger , calcium ion ( Ca2 + ) participates in a number of physiological responses both in animal and plant cells .

目的：探讨细胞内第二信使分子cAMP稳定的人工合成同系物双丁酰cAMP对大鼠烟雾吸入性肺损伤的防治作用。

AIM The purpose is to investigate the prophylactic effects of dibutyryl cAMP on the pulmonary smoke inhalation injury in rats .

结论：M3R与PI分解产生的第二信使分子IP3密切相关。

Conclusion : M 3R is much related to IP 3 .

不同的外界信号通过膜受体在膜内生成第二信使来进行跨膜信号转导的，都需要通过结构类似的各种G蛋白的介导。

Different external signals carried out transmembrane signal by generating second messengers transduction in the membrane , which all required a similar structure of the various G protein-mediated .

神经酰胺作为细胞凋亡的第二信使，参与多种细胞凋亡，它与凋亡相关因子bcl-2、NF-κB的关系一直是研究的重点。

Ceramide functions as a second messenger to several signaling pathways , and the relationship between it and bcl-2 or NF - κ B has always been emphasized .

Ca是植物许多重要生理过程的调控者，是细胞内信息传递物质，被称为第二信使。

Ca is the intracellular information transfer substances , regulating a number of important physiological processes in plants , and known as the " second messenger " .

腺苷受体与G蛋白偶联，通过改变第二信使系统活性来调节胞内蛋白激酶信号通路和调控下游靶基因表达。

Adenosine receptors are coupled to G proteins , though altering the activity of a second messenger system , can modulate protein kinase signaling pathways and regulate downstream target gene expression .

且细胞溶质Ca2+（[Ca2+]i）、活性氧（ROS）等许多第二信使参与了ABA诱导的信号转导过程。

Second messages such as cytosolic Ca2 + and reactive oxygen species ( ROS ) are involved in the ABA signal transduction .

鞘氨醇1磷酸（SPP）是重要的细胞第二信使，影响细胞的生长和死亡。

Sphingosine 1 phosphate ( SPP ) is an important second messenger involved in cell growth and cell death .

目的：探讨肌醇脂质和cAMP两个细胞内第二信使系统在血小板活化因子（PAF）诱导血小板聚集过程中所起到的作用和相互关系。

Objective : To investigate the effect of two intracellular second messenger systems , inositol lipid and cAMP , on PAF induced platelet aggregation .

GJ胞间通讯的基本形式是交换第二信使和电偶联。③发现了电偶联电位（spikelets）以及细胞之间的染料偶联现象。

Gap junctional intercellular communication includes the exchange of second messengers and electrical coupling between coupled cells .

在动物中提出环磷酸腺苷（cAMP）第二信使概念后，人们在研究中确认了另一种胞内信使&钙离子（Ca2+），二者共同作用，调节机体的各种生命活动。

People confirm another intracellular messenger-Ca2 + after the conception of two messenger ( cAMP ) has put forward in animal , adjusting different activity of life through effect each other .

细胞内第二信使、肾上腺皮质激素，PKC等因素可以调节钾通道基因的转录。

The factors , such as the second messagers in cells , glucocorticoid , PKC etc , may regulate the gene expression of potassium channels .

目的探讨多种第二信使在人垂体生长激素（GH）腺瘤GH分泌的调控作用。

Objective To investigate the regulatory effects of multiple intracellular " second messengers " on growth hormone ( GH ) secretion by human pituitary somatotrophinomas .

环磷酸腺苷（cAMP）和环磷酸鸟苷（cGMP）作为细胞内重要的第二信使，在介导阿片类物质依赖和戒断中发挥着重要的作用。

The cyclic AMP ( cAMP ) and cyclic GMP ( cGMP ), as important second messengers , play a vital role in producing drug tolerence and dependence .

磷脂酸（Phosphatidicacid，PA）是植物中重要的细胞内信号分子，被称为脂质第二信使，特别是几个PA的作用靶点已被克隆和鉴定。

Phosphatidic acid ( PA ) is an important intracellular signal molecule and is called the lipid second messenger because several targets of PA have especially been cloned and identified .

活性氧（ROS）能够对植物产生毒害作用，但它们作为第二信使在植物信号转导中起重要作用。

Reactive oxygen species ( ROS ) are highly toxic to plants . However , they can act as second messagers and play key roles in signaling transduction in plants .

目的：探讨低浓度DMSO（2%）和第二信使调节剂混合物（thrombosol）低温保存血小板的效果。

Objective : To study the in vitro activity of platelets following cryopreservation with mixed solution of low concentration DMSO ( 2 % ) and second-messenger effectors .

结论：GLP-1（7-36）NH2可以促进胰岛素分泌，在一定范围内呈剂量依赖性，其机制与GLP-1（7-36）NH2增加了胞内第二信使cAMP有关。

Conclusion : GLP-1 ( 7-36 ) NH2 stimulates insulin secretion in a concentration-dependent manner , and it probably relates to intracellular cAMP changes .

环腺苷酸cAMP和环鸟苷酸cGMP是具有细胞内信息传递作用的小分子，被称为细胞内第二信使，在新陈代谢，神经传递和细胞生长等多个方面起着重要的作用。

CAMP and cGMP are the intracellular molecules that can transmit intracellular messenger , known as intracellular second messenger . They plays an important role in many aspects of metabolism , neurotransmission and cell growth .

PIP2是细胞信号转导通路中的关键调节因子，经磷脂酶C（PLC）水解后可生成DAG及IP3，二者可作为第二信使，分别激活PKC与促使细胞内钙库释钙。

PIP_2 is a pivotal regulator in cell signaling pathway . DAG and IP_3 , which are generated from PIP_2 hydrolysis by PLC , act as second messengers to activate PKC and induce intracellular Ca release , respectively .

钙离子作为细胞内第二信使，广泛存在于体细胞内，因而钙通道拮抗剂（CCB）被广泛应用于心脏、骨骼肌和神经元等研究及心血管疾病治疗。

Calcium ion exists extensively in cells as the second messenger , and calcium channel blocker ( CCB ) is widely used to treat cardiac , skeletal muscular diseases .

H2O2作为第二信使参与了ABA的信号转导过程，但是，有关保卫细胞内ABA诱导H2O2产生的亚细胞定位至今未见报道，而这恰恰是理解气孔反应中氧化信号作用的关键问题。

It is well documented that H_2O_2 , as the second messenger , is involved in the signal transduction in the ABA-induced stomatal closure . However , little is known about the subcellular location of H_2O_2 production in the guard cells .

活性氧作为细胞内的第二信使激活转录因子NFκ-B，导致炎症相关基因的表达，促使中性粒细胞黏附，造成内皮炎性损伤；

Active oxygen as the second messenger can further activate transcription factor NF - κ B which then promotes the expression of the inflammatory related genes , promote the adhension of neutrophils and result in endothelial inflammatory damage .