翻译后修饰

甲基化修饰是真核生物中核小体组蛋白的一种极为重要的翻译后修饰。

Methylation is a major posttranslational modification for histones in eukaryotes .

蛋白质磷酸化作为一种极为重要的蛋白质翻译后修饰，几乎参与了生物体内的所有生命活动过程。

Protein phosphorylation , as an extremely important protein posttranslational modification , participates in almost all life activities .

中性丢失少、可区分亮氨酸和异亮氨酸等。这些特点使电子捕获解离充满魅力，特别在TopDown技术和翻译后修饰中具有广阔的应用前景。

All of these make ECD charming , especially in the field of Top Down strategy and post translational modification characterization .

本文从病理机制（特别是蛋白质翻译后修饰）、发现临床生物标签及治疗药物三个方面，对蛋白质组学在AD中的研究进展进行了综述。

The three aspects about the progresses in proteomics researches of AD were reviewed in this article .

氧化应激对p53翻译后修饰影响的研究进展

Influence of oxidative stress on p53 post-translational modifications

Tau蛋白的异常翻译后修饰与阿尔茨海默病

Abnormal post-translational modification of Tau protein and Alzheimer 's disease

序列分析表明，林麝IL-2及其受体结合域与水牛的高度保守，而在翻译后修饰的预测活性位点上和水牛的有所不同。

Sequence analysis of IL-2 showed that it had high homology with that of bubalus bubalis , except the difference of post-translational modification .

多聚ADP核糖聚合酶（PolyADP-ribosepolymerase，PARP）是广泛存在于除酵母以外真核细胞中的蛋白质翻译后修饰酶。

Poly ( ADP-ribose ) polymerase ( PARP ) is a post-translational modification enzyme which exists in eukaryote cells , except yeasts .

SUMO分子是一种结构上与泛素相似的分子，它参与蛋白质翻译后修饰。

The small ubiquitin-related modifier ( SUMO ) family proteins are structurally and mechanistically related to ubiquitin .

泛素化修饰属于蛋白质翻译后修饰，在细胞的各种生命活动进程如细胞周期、信号转导、转录调节、DNA修复、细胞凋亡等中发挥着至关重要的作用。

The ubiquitination , which belongs to the protein post-translational modification , plays a critical role in the life process of cells , such as cell cycle , signal transduction , transcriptional regulation , DNA repair , and cell apoptosis and so on .

因此，研究HIF-1α的翻译后修饰，不仅有助于我们加深对HIF-1作为一个多种疾病的治疗靶标的认识，更能为我们理解类似转录因子自身的调控提供思路。

Therefore studies in this aspect are helpful in understanding not only HIF-1 α as a therapeutic target for the diseases but also the regulation of other similar transcriptional factors .

通过与其他蛋白的相互作用以及翻译后修饰是调节AP-2活性的两个重要方面。

Both interaction with various proteins and post-translational phosphorylation play an important role in controlling the activity of AP-2 proteins .

由于以磷酸化和糖基化为主的Tau蛋白异常翻译后修饰与神经元纤维缠结关系密切，因此，关于Tau蛋白在AD发生发展中的作用已成为近年AD研究领域的一大热点。

Neurofibrillary tangles are closely correlated to abnormal hyperphosphorylation and glycosylation of tau protein , thus the role of tau protein in the development of AD has been a focus in the current study of AD.

qRT-PCR结果提示蛋白质表达水平的改变可能不完全源于mRNA的变化，很可能也与蛋白质的翻译后修饰或降解有关。

The results of qRT-PCR suggested that changes in protein levels may not be entirely due to the mRNA change . It may be related to protein post-translational modification or degradation , too .

作为蛋白质的翻译后修饰，泛素及其类似物（ubiquitin-likemodifiers，Ubls）对底物的修饰被认为是真核细胞内一种重要的调节机制。

Post-translational modification by ubiquitin and ubiquitin-like modifiers ( Ubls ) is one of the most important mechanisms regulating a wide range of cellular processes in eukaryotes .

以往研究表明20αHSD活性的调节不是通过糖基化、磷酸化或去磷酸化等翻译后修饰实现的，而是转录水平的调节为主。

It was indicated that regulation of 20a HSD activity was not due to post-translational modification by either phosphorylation cycle or glycosylation , but rather at the transcription level of 20a HSD gene expression in previous research papers .

硝基化是氧化应激条件下由活性氮物质引起的主要蛋白质翻译后修饰之一，其中一种主要产物是3-硝基化酪氨酸（3NT）。

Nitration is a major modification caused by reactive nitrogen species in the condition of oxidative stress , one of the major product is 3-nitrotyrosine ( 3NT ) .

蛋白的翻译后修饰是蛋白的一种重要的修饰调控方式。

Protein post-translational modification is an important type of protein regulation .

蛋白质巯基亚硝基化&一种典型氧化还原依赖的蛋白质翻译后修饰

S-nitrosation : The Prototypic Redox - based Post-translational Modification of Proteins

因此，蛋白质的磷酸化修饰是翻译后修饰蛋白质组研究中的热点之一。

So , research of protein phosphorylation is a hot spot nowadays .

泛素化是真核生物中最重要的翻译后修饰之一。

Ubiquitination is one of the most important protein post-translational modifications in eukaryotes .

蛋白质翻译后修饰和细胞信号通路的生物信息学

Bioinformatics of Protein Post-translational Modifications and Cell Signaling Pathways

翻译后修饰有甲基化、磷酸化、乙酰化等。

These posttranslational modifications include methylation , phosphorylation , acetylation and so on .

植物中一氧化氮参与的蛋白质翻译后修饰

Nitric Oxide Participates Post-translational Modification of Proteins in Plants

染色质的结构受组蛋白翻译后修饰的影响。

This architecture of chromatin is strongly influenced by posttranslational modifications of the histones .

年龄和离体翻译后修饰对兔α-晶状体蛋白分子伴娘活性的影响

Effects of aging and post-translational modifications on molecular chaperone-like activity of α - crystalline

之所以出现这种差异，推测可能与该基因翻译后修饰，特别是与糖基化有关。

The difference may be to relate with post-translational modification , especially with glycosylation .

酿酒酵母表面展示工程是一个新兴的蛋白表达系统，由于它能进行蛋白翻译后修饰，能方便地对表达的蛋白产物进行检测和筛选，近年来应用研究发展迅猛。

Saccharomyces cerevisiae cell-surface engineering is a newly genetic expressing system for fusion heterologous gene .

在众多的翻译后修饰中可逆的磷酸化修饰是最为重要同时也是存在最为广泛的修饰方式。

The reversible phosphorylation is the most important and also the most extensive modification form .

翻译后修饰蛋白质组学研究的技术策略

Technique Strategies of Modification-specific Proteomics Study