肾毒性

维生素B1对镉致肾毒性干预作用研究

Study on Thiamin Intervention in Cd-induced Renal Toxicity

目的大鼠慢性染镉后给予GSH、VitC、DMPS，探讨这3种物质对镉肾毒性的影响。

Objective GSH , Vit-C and DMPS were given to rats to study the effects on the renal toxicity induced by chronic exposure to cadmium .

茶多酚联合维生素C对阿霉素肾毒性的保护作用

Protective Effect of Tea Polyphenol Combined with Vitamin C on Renal Damage Induced by Adriamycin

洛沙坦对环孢素A慢性肾毒性大鼠核因子κB的影响

Effect of losartan on nuclear factor kappa B in a rat model of chronic cyclosporine A nephrotoxicity

方法将108例因肾毒性药物所致急性肾损害患者为三组，A组36例，用前列地尔10μg，静脉推注，1次/d；

Methods 108 patients with drug-induced acute renal damage were divided into three groups at random .

目的：研究P选择素在高胆固醇血症小鼠肾脏的表达，探讨脂质肾毒性损伤的机制。

Objective : To detect the expression of P-selectin in mice with hypercholesterolemia , and to explore the mechanism of toxic injury to the kidney induced by lipid .

在CsA慢性肾毒性组织中，TGFβ1的mRNA及蛋白表达显著增加；

The expressions of TGF - β 1 mRNA and protein increased significantly in CsA-treated rats .

结论TP在一定程度上能预防DDP所致的肾毒性。

Conclusion TP can prevent kidney toxicity induced by DDP in certain degree .

DMF组无脱发及心脏毒性反应，DDP的肾毒性经水化后得以预防。

The nephrotoxicity in DMF group can be prevented by hydration .

其中红曲色素广泛用于食品着色，莫那可林K用作降血脂的药物，而桔霉素则对脊椎动物包括人体有肾毒性。

Monacolin K , which has been proven to have cholesterol-lowering effects ; and Citrinin , which is moderately nephrotoxic to vertebrates including humans .

慢性肾毒性是环孢霉素A（CsA）的主要副作用。

Chronic nephrotoxicity is main side effect of cyclosporine A ( CsA ) .

VE对OTA引起小鼠肾毒性的缓解作用研究

The Study on Mitigation of OTA Induced Mouse Nephrotoxicity by VE

转化生长因子-β1在大鼠CsA慢性肾毒性中作用的研究

Roles of transforming growth factor - β 1 in cyclosporin A-induced chronic nephrotoxicity in rats

E-cadherin是镉肾毒性的相对较早的靶部位；

E-cadherin may be the relatively early target of nephrotoxic actions of Cd .

加味黄连阿胶汤对顺铂致肾毒性大鼠TIMP-1表达的影响

Effects of Modified Huanglian Ejiao Decoction on Expression of TIMP-1 in Cisplatin-induced Nephrotoxicity Rats

传统的治疗药物如巯基络合剂EDTA，因其促进汞的排泄无特异性，易导致微量元素代谢紊乱，同时也会导致肾脏近曲小管上皮细胞受损伤，甚至产生肾毒性。

Many conventional medicines like EDTA can result in metabolic disorders of microelements , even renal toxicity .

结论：RTA的发生和两性霉素B的剂量、肾毒性药物的合用有关。

CONCLUSION : Amphotericin B associated RTA is related to the dosage of amphotericin B and the concurrent medications of nephrotoxic drugs .

研究茶多酚（TP）对顺铂（DDP）所致肾毒性作用的保护作用。

Purpose To study the protective effects of tea polyphenols on kidney damage caused by cisplatin ( DDP ) .

血、尿β2-MG对大剂量顺铂肾毒性的早期诊断价值

Early diagnosis value of serum and urine β _2-MG in HD-DDP nephrotoxicity

目的：研究三七皂苷（PnS）对顺铂肾毒性的防护作用。

AIM : To study protective effects of Panax notoginseng saponins ( PnS ) against cisplatin-nephrotoxicity .

但是马兜铃属植物药因含有马兜铃酸（AristolochicAcid，AA）而具有潜在的肾毒性和致癌性。

The plant-medicines of Aristolochia have been shown to be a nephrotoxicity and a potent carcinogen , due to Aristolochic acid ( AA ) .

丹参能使血浆PRA、AngⅡ水平降低，对CsA的慢性肾毒性有明显的保护作用。

Salvia compound can decrease the levels of PRA and Ang ⅱ, and have preventive effects on chronic nephrotoxicity .

FK506肾毒性的预防

Prevention of FK506-induced nephrotoxicity

维拉帕米对FK506肾毒性的防治作用与肾脏P-450的关系

Correlation of FK 506-induced nephrotoxicity with the renal microsomal cytochrome P-450 the preventive effect of verapamil

时间（英文）奈达铂（Nedaplatin）在大鼠体内的肾毒性和骨髓抑制的时辰毒理学研究

Medication Time Involved in Nedaplatin-induced Nephrotoxicity and Myelosuppression in the Rats

PTX对高胆固醇血症环境下所致的造影剂肾毒性有保护作用。

PTX can protect the renal tissue from nephrotoxicity induced by HOCM in hypercholesterolemia .

CDDP肾毒性的机制之一是氧化应激，但是氧化性损伤并不能完全解释顺铂诱导的肾毒性。

It has been reported that oxidative stress was one of the mechanisms of CDDP-induced cytotoxicity .

目的：从基因水平探讨复方丹参注射液防治环孢菌素A（CsA）慢性肾毒性的机理。

Objective : To explore the mechanism of protective effect of Compound Salvia Injection ( CSI ) on experimental cyclosporin A induced nephrotoxicity .

CsA血药浓度监测对制定给药方案、肾毒性和排斥反应的鉴别，有重要的临床意义。

CsA therapeutic drug monitoring has great significance on drafting the clinical protocols for CsA and differentiation of the nephrotoxicity and allograft rejection .

方法：用兔抗鼠肾毒性血清静脉注射制作NSN模型，取NSN大鼠心肌组织作光镜、电镜和免疫组化IgG染色检查。

Methods : Micro and electron microscopic immune pathological examination of myocardium was performed in rats with NSN .