胆碱能受体

大鼠烟碱依赖对脑皮层M、N胆碱能受体的影响

Effect of nicotine dependence on m , n cholinergic receptors in rat brains

胆碱能受体在大鼠膀胱ICC样细胞的表达

Expression of muscarinic acetylcholine receptors on Cajal-like cells in stretched prepared rat bladder

神经型烟碱性胆碱能受体α4亚单位基因多态位点1860（C→T）与吸烟的相关性以流行病学和病例调查为基础的抽样调查

Correlation of polymorphisms in the neuronal nicotinic acetylcholine receptor alpha 4 subunit gene 1860 ( C → T ) with cigarette smoking : Sampling survey based on epidemiology and case investigation

结论：M3胆碱能受体基因与中国人群中HPNCC的发病可能无密切关系。

Conclusion : M3 cholinergic receptor gene might have little relation with HNPCC in Chinese population .

目的：研究M3型胆碱能受体与配体的结合可否导致钙离子/钙调素依赖性蛋白激酶Ⅱ（CaMkinaseⅡ）的激活。

AIM : To study whether M3 receptor occupation would lead to activation of calcium / calmodulin-dependent protein kinase ⅱ ( CaM kinase ⅱ ) .

胆碱能受体激动剂和拮抗剂对体外CFU-GM增殖和分化的影响

Effect of cholinergic agonist and antagonist on proliferation and differentiation of CFU-GM in vitro

但目前国内外对人LES受体类型及其分型以及调节机制的研究，主要局限于胆碱能受体，对于G蛋白的研究则相对甚少。

However , people at home and abroad researched LES regulatory mechanism mainly restricted to receptors , for the studying of G proteins , are relatively fewer .

结果提示：M胆碱能受体阻断剂东莨菪碱可以同时调制HPC癫痫网络成员电场和细胞的瞬时编码信息；

It suggested that the temporal coding information of the member fields and neurons could be modulated by the scopolamine simultaneously within hippocampal epileptic network .

注射N型胆碱能受体拮抗剂六烃季胺则抑制了免疫应答。以上结果提示：中枢神经系统内的Ach可影响体液免疫功能，可能具有免疫抑制效应；

These results suggested that Ach in central nervous system can affect the primary humoral immune response to SRBC in rats , but Ach in periphery may not affect the immune response .

中国人HNPCC家系的临床特征及M3胆碱能受体基因（A）8区突变检测

Clinical features and mutation analysis of a poly - ( A ) _8 tract in M3 cholinergic receptor gene in Chinese HNPCC families

方法用ELISA法检测62例DCM患者和76例健康人血清抗β1肾上腺能受体与M2胆碱能受体自身抗体；

Methods A assay called ELISA was used to detect the levels of serum anti β 1 and M 2 receptor antibodies in 62 patients with DCM and 76 healthy subjects .

P1（A1）嘌呤受体，P2嘌呤受体，M胆碱能受体，α2肾上腺素受体，D2多巴胺受体，5-羟色胺受体及H1组胺受体激动剂或拮抗剂可通过突触前机制调节ATP释放。

CONCLUSION : ATP is released from the rat SCG and the release of ATP can be presynaptically modulated by P1 ( A1 ), P2 , muscarinic , α 2 adrenergic , D2 , 5-HT , and H1 receptor agonists and antagonists .

目的研究呼吸道合胞病毒（RSV）感染豚鼠后肺组织β肾上腺素能受体（β受体）和Μ胆碱能受体（Μ受体）的变化。

Objective To investigate the effects of respiratory syncytial virus ( RSV ) infection on β - Μ - receptor density and function in lung tissue of guinea-pig .

用体外琼脂培养法研究胆碱能受体激动剂和拮抗剂对粒、单造血祖细胞（CFU-GM）增殖和分化的影响。

This study observed the effect of cholinergic agonist and antagonist on proliferation and differentiation of rganulocytemacrophage haemopoietic progenitor cells ( CFU-GM ) in vitro .

目的：了解乙酰胆碱（ACh）对人胃粘膜上皮细胞和胃腺癌细胞烟碱型胆碱能受体（N受体）β亚单位的影响及两者间的差异。

Aim : To study the influence of acetylcholine ( ACh ) on nicotinic receptor ( N receptor ) β - subunit of the gastric epithelia and the gastric adenocarcinoma cells , and the difference of both cells .

采用放射配体结合实验，研究大鼠对烟碱形成依赖后脑皮层M、N胆碱能受体的变化，结果显示，形成烟碱依赖后脑皮层M－受体的亲和力与密度均无改变；

The effects of nicotine dependence in M and N cholinergic receptors ( M-and N-R ) in rat brains were studied by radioligand-receptor binding assay . The results showed that after developing nicotine dependence ( 1 ) the affinity and density of M-R in the brains unchanged ;

经M受体阻断剂阿托品的拮抗试验，提示6d是潜在的M胆碱能受体激动剂。

Since this agonistic effect was blocked by atropine , an exclusive muscarinic-receptor antagonist , it suggested that 6d was a potential muscarinic cholinergic agonist .

结果提示：ACh在较大的浓度范围内均可促进细胞免疫功能，ACh增强细胞免疫的作用可能是通过M型胆碱能受体实现的。

These studies suggest that ACh at a wide range of concentration can enhanced the cellular immunity and the action of ACh modulating T lymphocyte may be mediated by muscarinic cholinergic receptors .

目的：分析中国人遗传性非息肉病性大肠癌（HNPCC）家系的临床特征并检测这些家系中M3胆碱能受体基因（A）8区的突变情况。

Objective : To characterize the clinical features of Chinese HNPCC families and to screen the mutations of a poly ( A ) 8 tract in M3 cholinergic receptor gene in these families .

目的：采用乙酰胆碱（ACh）和阿托品对豚鼠左心室流出道慢反应自律细胞电活动的影响来间接反映迷走神经对左心室流出道自律细胞的支配和胆碱能受体的分布。

Objective : To investigate the innervation of parasympathetic nervous system and the distribution of muscarinic receptor ( M-R ) on pacemaker cell membrane in guinea-pig left ventricular outflow tract ( aortic vestibule ) .

应用放射配基结合法测定了人参皂甙Rb1和Rg1对α1，α2，β肾上腺素能受体、M胆碱能受体、5-羟色胺、多巴胺及GABA等七种受体的作用。

Effects of ginsenoside Rb_1 and Rg_1 on seven kinds of central neurotransmitter receptors , α _1 , α _2 and β - adrenoceptors , 5-HT , DA , GABA and M-cholinergic receptors , were measured .

免疫组化观察大鼠脑内ChAT的表达。结果与对照组比较，模型组大鼠学习记忆能力明显下降（P0.01），烟碱型胆碱能受体表达减少（P0.05），ChAT免疫阳性神经元减少（P0.05）。

Results Compared with the control rats , the capabilities of learning and memory were lowered significantly ( P0.01 ) and the expressions of both the nicotinic acetylcholine receptors and the ChAT positive neurons were decreased greatly in the model rats ( P0.05 ) .

目的观察抗胆碱能受体阻滞剂在儿童哮喘治疗中的作用及肺功能呼气峰流速（PEFR）的变化。

Objective To asses the effect of anticholinergic agent on the treatment of child asthma and to study the changes in peak expiratory flow rate ( PEFR ) .

ACh对离体豚鼠心房肌细胞APD的脱敏有浓度依赖性与时间依赖性；脱敏的发生可能与毒蕈碱型胆碱能受体及Ik，ACh电流有关。

CONCLUSION : The effect of desensitization on APD to ACh in atrial cells is concentration and time dependent , these effects may be related to the change of the muscarinic receptor and the potassium channel .

目的观察大鼠暴露尼古丁对中脑腹侧背盖区（VTA）、黑质（SN）和大脑皮质α-7型神经烟碱胆碱能受体（α-7-nAChRs）表达的影响。

Objective To observe the regulation of α - 7 neuronal nicotinic acetylcholine receptors (α - 7-nAChRs ) by nicotine in the ventral tegmental area ( VTA ), the substantia nigra ( SN ) and the cortex of the rat . Methods Nicotine exposed animal models were established .

上述结果提示，在犬右心房组织中，293B的负性频率和负性肌力作用与M胆碱能受体和β-受体无关。

These results suggest that the negative chronotropic and inotropic responses to 293B in the right atrium of the dog are not related to muscarinic receptor and β - adrenoceptor .

磷脂酰肌醇代谢对体温调节中枢胆碱能受体功能的调节作用

Modulatory effect of phosphatidylinositol turnover on cholinergic receptors in thermoregulation center

鼠脑M&胆碱能受体测定及环类抗抑郁剂的作用

Effect of Antidepressants on Muscarinic Cholinergic Receptors of Rat Brain in vitro

乐果的亚急性用药对大白鼠脑M-胆碱能受体的影响

Effects of Subacute Administration of Rogor on Muscarinic Receptor in Rat Brain

胆碱能受体阻断剂对胃酸分泌和胃粘膜血流的影响

Effect of the cholinergic-receptor agonist on gastric acid secretion and mucosal blood flow