胶质细胞增生
- 网络Gliosis;GFAP;microgliosis
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动物实验已证实,一次长时或反复的癫痫发作可引起海马等易损区神经元坏死、反应性胶质细胞增生及苔藓纤维发芽等病理改变,并可能是癫痫发作得以长期维持的基础。
Animal experiments have demonstrated that prolonged and recurrent seizure activity can result in a series of pathological changes including hippocampal neuronal cell death , reactive gliosis and mossy fiber sprouting , which may be a basis for chronic and recurrent seizures of epilepsy .
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方法对34例脑胶质细胞增生症进行病理分级、分型;
Methods The pathologic slices of 34 cases of gliosis were studied .
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反应性胶质细胞增生和正常脑组织中bcl-2和p53均为阴性。
No expression of Bcl 2 and p53 protein was seen in reactive proliferation and normal brain tissues .
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高压氧(02MPa)暴露第3d,组织间隙水肿消退,神经胶质细胞增生。
When the animals were exposed to HBO ( 0.2 MPa ), their intercerebral edema was absorbed and the glial cells proliferated at the 3rd d.
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结论IGE患者丘脑神经元丧失及胶质细胞增生可能是其共同的病理特征;
Conclusion The common pathologic features of IGE are the loss of neuron and hyperplasia of colloid cell .
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目的研究脊髓损伤后电针治疗对星形胶质细胞增生及其内源性神经生长因子(Nervegrowthfactor,NGF)表达的影响。
Objective To investigate the effects of electro-acupuncture on the proliferation of astrocytes and the expression of the endogenous nerve growth factor ( NGF ) after spinal cord injury ( SCI ) .
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结论视网膜色素上皮细胞条件培养液促进视网膜神经胶质细胞增生,细胞间的相互作用对于PVR等的产生和发展是非常重要的。
Conclusion Interaction of RG cells and RPE cells is related to the formation and development of PVR .
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15d有胶质细胞增生。
Gliocyte hyperplasia could be found on 15 th day .
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其作用机理与减轻NO对视网膜的毒性、调控视网膜神经递质的异常,增强视网膜神bFGF表达、抑制神经胶质细胞增生,从而抑制视网膜细胞凋亡有关。
The mechanism might relate to inhibit the apoptosis and gliosis , enhance the expression of bFGF in retina , and regulate the neural transmitter in retina .
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P组除了有脑组织水肿及神经元肿胀,神经元变性,神经元排列紊乱外,神经元坏死外,还有胶质细胞增生,脑组织内胶质细胞散在、弥漫、灶性或结节状增生。
P group in addition to brain edema and neuronal swelling and degeneration of neurons , neurons disordered , the neuronal death , there is proliferation of glial cells , glial cells within the brain tissue scattered , diffuse , focal or nodular hyperplasia .
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给药后1~8周光镜显示右侧DRG细胞变性、坏死、消失,神经胶质细胞增生。
Light microscopic examination revealed degeneration , necrosis and disappearance of cells and hyperplasia of gliacytes in right DRG at 1-8 weeks after injection .
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1周时损伤处视神经出现溃变,神经胶质细胞增生,视网膜神经节细胞(Retinalganglioncells,RGCs)形态改变不明显;
In 1 week , the optic nerve began to degenerate in injured part and the glia cell had proliferated , but the forms of retinal ganglion cells ( RGCs ) were normal .
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手术14d后缺血中心区和半影区可见大量胶质细胞增生。
There was great deal of collagenocyte that appeared in ischemic center and penumbra region at postoperative 14 days .
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C型Niemann-Pick病小鼠P27~(kipl)表达异常与神经元变性和星形胶质细胞增生
Deregulation of P27 ~ ( kipl ) is related with neuronal degeneration and astrocytosis in a mouse model of Niemann-Pick disease type C
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结果6例AD中有3例临床合并帕金森综合征,其黑质、蓝斑均有不同性质及程度的损伤,2例系非特征性色素细胞脱失伴胶质细胞增生,1例为球形体色素变性。
Results Coexistent Parkinsonism was present in 3 cases of AD. Pathological examination revealed nonspecific degeneration , including pigmented neuronal loss and gliosis in substantia nigra and locus ceruleus in 2 cases and spheroid pigmentary degeneration in one case .
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视神经损伤后依次经过水肿、胶质细胞增生和萎缩三个阶段,水肿期即7d以内治疗效果好。
After injury , optic nerve goes through 3 stages : edema , hyperplasia and atrophy . The treatment can get better therapeutic efficacy in edema stage . 3 .
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铁离子组可见海马锥体细胞脱失和胶质细胞增生,术后15d达到高峰。
The loss of hippocampal pyramidal cell and the proliferation of glial cell were observed in Fe3 + group , and the peak was at day 15 after the operation .
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结论肋间神经移植+NGF、BDNF能促进神经轴突的生长,抑制胶质细胞增生,在局部使雪旺氏细胞增殖,利于脊髓再生。
Conclusion The procedure of intercostal nerve transplantation combining NGF and BDNF can promote the regeneration of axon and schwann cell , restrain the proliferation of glial cell , and it 's a good method for the generation of injured spinal cord .
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目的:研究GDNF基因体内转染对大鼠面神经损伤后运动神经元的保护作用,为基因治疗周围神经损伤提供依据。神经元周围胶质细胞增生。
Objective : To explore protective effects of expression of glial cell line-derived neurotrophic factor ( GDNF ) gene in vivo on motor neurons of facial nerve in rats and provide basis for the gene therapy of peripheral nerve injury .
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目的研究7β羟基胆固醇(7βOHCH)抗脑损伤后反应性星形胶质细胞增生的作用及其意义。
Objective To demonstrate anti-proliferative property and significance of 7 β - hydroxycholesterol ( 7 β OHCH ) on astrocytes after brain injury .
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结果:改良的Klolein术式造模40天后,造模组兔眼视觉电生理的F-VER降低或丧失;神经纤维数量显著减少、脱髓鞘、神经胶质细胞增生。
Results : In the visual function of optic nerve , F-VER was significantly lowered and the amount of optic nerve fiber was significantly decreased with a result of demyelination and neuroglia cell hyperplasia 40 days after establishing the TOA model .
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星型细胞及小胶质细胞增生、活化是脑老化的重要形态学改变,后者可能与微血管结构改变有关;
Activations of astrocyte and microglia participate in brain aging .
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3~6天出现胶质细胞增生改变。
At 3 ~ 6d , gliosis was present .
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血管性痴呆大鼠星形胶质细胞增生与TNF-α的表达
Astrocyte proliferation and expression of TNF - α on vascular dementia in rats
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白质内明显的小血管硬化和胶质细胞增生。
There were obvious sclerosis of small vessel and collagenous hyperplasia in white matter ;
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增殖细胞核抗原在脑胶质细胞增生症的表达及其与病理相关性研究
Analysis of proliferating cell nuclear antigen ( pcna ) expression in gliosis : relationships and pathology
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染色发现在海马区有胶质细胞增生,神经元细胞数量减少且形态异常,凋亡细胞数量明显增多。
In hippocampus , neurons showed less numbers and morphologic abnormality , while glial cells proliferated .
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脑组织呈现明显的多种退行性改变,伴胶质细胞增生。
At the same time , the manifold retrogression and glial cells hyperplasia in brain could be found too .
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光镜下肝脏、脾脏有非典型肉芽肿形成,肺多呈间质性肺炎,脑神经胶质细胞增生;
Atypical granulomas appeared in the liver and spleen and interstitial pneumonia and hyperplasia neuroglia cell in cerebrum were observed .
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红藻氨酸诱导慢性颞叶癫痫鼠脑海马胶质细胞增生和突触重建的研究
Experimental study of gliosis and synaptic reorganization in the hippocampus of chronic temporal lobe epilepsy rats induced by kainic acid