西红花

结果：最佳处方为：甘露醇5g，西红花5g（1∶1），50mg西红花总苷粉针剂能在2mL注射用水中迅速溶解。

RESULTS : The best formula was composed of mannitol ( 5 g ) and Crocus sativus ( 5 g )( 1 ∶ 1 ) . Crocus sativus total glucoside for injection ( 50 mg ) could dissolve quickly in water ( 2 mL ) .

西红花酸可以显著抑制DNA的上述损伤。

Crocetin can prevent DNA damages induced by these factors .

结论西红花酸对ISO所致急性心肌缺血有显著的保护作用。

Conclusion Crocetin could alleviate the acute myocardial ischemia induced by ISO in rats .

RP-HPLC法研究西红花酸在大鼠体内的药代动力学和组织分布特性

Study on Pharmacokinetics and Tissue Distribution of Crocetin in Rats by RP-HPLC

西红花籽油对高脂血症大鼠血清IL-6和TNF-α的影响

Effects of crocus seed oil on the content of serum il-6 and tnf - α in the hyperlipidemia rats

结果高、低剂量的西红花酸能显著降低动脉粥样硬化大鼠血清TC、LDL-C和MDA含量；

Results High-and low-dosages of CCT were found significantly to reduce serum TC , LDL-C , and MDA level ;

西红花酸对H2O2诱发心肌细胞凋亡及相关调控蛋白caspase-3、Bcl-2表达改变的影响

Effects of crocetin on the apoptosis and the changes of its related regulating proteins caspase-3 and Bcl-2 induced by H_2O_2 in myocardial cells

结论：西红花酸能够减轻H2O2对培养心肌细胞的损伤性凋亡作用，可能与稳定细胞内凋亡相关调控蛋白caspase-3、Bcl-2的功能有关。

The mechanisms may involve the balance of the functions of the apoptosis-related regulating proteins , caspase-3 and Bcl-2 protein .

结论西红花苷对LDL所致内皮细胞损伤有保护作用。

CONCLUSION It indicates that crocin has protective effects on cultured calf aortic endothelial cells injured by low-density lipoproteins .

西红花酸对高脂血症家兔LDL氧化易感性及血清Ox-LDL水平的影响

Effects of Crocetin on the Susceptibility of LDL to Oxidation and Serum Level of Ox-LDL in Hyperlipidemic Rabbits

方法采用高胆固醇饮食饲养SD大鼠2个月，造成高脂血症模型，观察西红花苷对大鼠血脂质的影响。

Method : Hyperlipemia model was established by feeding heavy cholesterol for 2 months and the effect of crocin on blood lipid in experimental hyperlipemia rats was observed .

结论：西红花苷可能是通过调节Bcl-2，Bax和Caspase-3基因表达抑制Triol诱导的内皮细胞凋亡。

CONCLUSION : Crocin possibly inhibit Triol-induced apoptosis of ECs by decreasing the gene expression of Bax and Caspase-3 and increasing the gene expression of Bcl-2 .

目的：探讨西红花酸对过氧化氢（H2O2）诱导的培养心肌细胞凋亡及相关调控蛋白caspase-3、Bcl-2表达改变的作用。

AIM : To observe the effect of crocetin on the apoptosis and the changes of its related regulating proteins caspase-3 and Bcl-2 expression induced by hydrogen peroxide ( H_2O_2 ) in cultured cardiomyocytes .

西红花酸1.0,0.1μmol/L明显降低培养上清液中LDH活性、提高MSD的活性及MMP、降低心肌细胞凋亡率，与模型组比较差异显著（P0.05）。

Results Compared with the model group , crocetin significantly decreased the activity of LDH in culture supernatant and the ratio of cardiac myocyte apoptosis , markedly increased the activity of MSD and MMP .

结果：西红花苷-1经大鼠在体小肠回流4h后药量消失率分别为：十二指肠10.1%，空肠9.55%，回肠9.15%，结肠12.24%。

The absorption and excretion rate of crocin-1 were determined by HPLC . Results : Elimination rate of crocin-1 in various intestinal segments after in situ perfusion for 4 hours was as follows : duodenum 10.1 % jejunum 9.55 % , ileum 9.15 % , colon 12.24 % .

西红花苷调血脂作用的实验和临床研究

The Experiment and Clinical Study on The Hypolipidemic Effect of Crocin

低压液相色谱法分离、制备西红花甙

Separation and Preparation of Crocins in Saffron by Low-pressure Liquid Chromatography

比较西红花酸和西红花苷对异丙肾上腺素损伤心肌的作用

Comparison of effect on isoproterenol-induced myocardial injury between crocetin and crocin

大孔吸附树脂对栀子西红花总苷吸附性能的研究

Study on adsorption of crocin in gardenia with macroporous resin

西红花酸对心肌细胞氧化应激性损伤的作用

Effects of Crocetin on the Myocardial Cell Damages Due to Oxidative Stress

西红花酸对大鼠血浆胆固醇的调节作用及其机制研究

Hypocholesterolemic effect of crocetin on serum cholesterol in rats and the mechanism

西红花糖甙分离、制备、分析方法发展概况

Development Survey of Separation , Preparation and analysis of Coins

西红花籽油对大鼠脂质代谢的影响

Effect of Crocus seed oil on lipid metabolism in rats with hyperlipemia

目的：观察西红花膏的药理作用。

Objective : To observe pharmacodynamic action of Safflower paste .

西红花总甙对鹌鹑实验性动脉粥样硬化的影响

Effect of Crocins on Experimental Atherosclerosis Formation in Korean Quails

沪郊西红花球茎腐烂病害的发生和药剂防治

Study on occurrence and chemical control of saffron corm rot in Shanghai suburbs

西红花的药理作用和分离制备及分析方法概况

Review of saffron in medicine separation preparation and analyses

中华鳖卵对高血糖模型大鼠血糖代谢的影响研究西红花苷对高脂血2型糖尿病模型大鼠降血糖和降血脂作用

Effects of Chinese soft-shell turtle egg on blood glucose metabolism in hyperglycemic rats

西红花苷对低密度脂蛋白所致鹌鹑内皮细胞损伤的保护作用

Protective effects of crocin on cultured calf aortic endothelial cells injured by low-density lipoproteins

种植密度和氮肥施用量对西红花球茎产量的影响

Influences of Planting Density and Quantity of Nitrogen Fertilizer on Bulb Yield of Saffron