过氧根
过氧根
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过氧亚硝酸根对胰岛素信号转导的调控作用及其机理
Regulation Mechanism of Insulin Signal Transduction Pathway by Peroxynitrite
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生物体内NO和超氧阴离子快速反应生成的过氧亚硝酸根离子是一种强细胞毒性物质,可以硝化胰岛素酪氨酸残基。
Peroxynitrite is a potent cytotoxic agent produced by rapid combination of NO and O-2 · in vivo , and it can nitrate tyrosine residues of insulin .
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为了探讨不同物质对过氧亚硝酸根离子硝化胰岛素的抑制作用,建立了一种比较不同化合物抗胰岛素硝化相对活性大小的方法。
To investigate the inhibition of different compounds on the nitration of insulin by peroxynitrite , a method applied to compare the relative inhibitory activity was established .