头孢噻肟钠

方法采用现版的不同药典的相关HPLC法及HPLC-MS分析，研究头孢噻肟钠的完全杂质谱。

Methods The current HPLC methods in different pharmacopoeia and HPLC-MS analysis were performed to study on the complete impurity profile of Cefotaxime Sodium .

结果：头孢噻肟钠的变态反应发生率最高，血液系统、肾脏系统、心血管系统、神经系统以及呼吸系统的不良反应发生率低，但危险性高。

Results : The incidence of allergic reaction was the highest in all adverse reaction of cefotaxime sodium . Though the incidence of adverse reaction is low in blood system , kidney system , cardiovascular system , nervous system , respiratory system , it would be dangers when it happened .

HPLC法测定注射用头孢噻肟钠/舒巴坦钠的含量

Determination of cefotaxime sodium / sulbactam sodium for injection by HPLC

HPLC测定烧伤患者肾脏透析排出液中头孢噻肟钠的含量

Determination of Sodium cefotaxime in renal dialysate from burn-injured patients by HPLC

HPLC测定注射用头孢噻肟钠他唑巴坦钠的含量及有关物质

Determination of two components and related substances in Cefotaxime sodium and Tazobactam sodium for injection by HPLC

目的考察注射用头孢噻肟钠在聚氯乙烯（PVC）输液袋、聚丙烯（PP）塑料输液瓶、非聚氯乙烯（NPVC）多层共挤膜输液袋及玻璃瓶包装输液中的稳定性差异。

OBJECTIVE : To observe the stability of cefotaxime sodium for injection in PVC infusion bags , PP plastic infusion bottle , non-PVC multilayer polymer infusion bags and glass bottles .

目的：考察4℃、25℃、37℃下24h内替硝唑葡萄糖注射液与注射用头孢噻肟钠的配伍稳定性。

OBJECTIVE : To evaluate the stability of tinidazole and cefotaxime sodium mixed in infusion fluid at 4 ℃ , 25 ℃ and 37 ℃ for 24 hours .

结论：在4℃6h内、25℃2h内、37℃1h内，替硝唑葡萄糖注射液与注射用头孢噻肟钠的配伍液稳定。

CONCLUSION : Tinidazole and cefotaxime sodium mixed in infusion fluid were stable at 4 ℃ for 6 ℃ hours , 25 for 2 hours and 37 ℃ for 1 hour .

治疗组：静脉注射头孢噻肟钠，每次1.0～2.0g，每8h静注1次，疗程7～14d；

Treatment group : 1.0 ~ 2.0g cefotaxime sodium was given by intravenous injection three times a day for7 ~ 14d ;

方法：186例细菌性肺炎患者随机分为A、B、C组，分别给予头孢噻肟钠、左氧氟沙星、氯唑西林钠治疗，观察各组疗效、不良反应，并运用药物经济学方法进行分析。

METHODS : 186 patients with bacterial pneumonia were selected and randomly divided into 3 groups . Group A were treated with cefotaxime , Group B with levofloxacin and Group C with cloxacillin sodium . The curative effects and adverse drug reactions were observed and analyzed by pharmacoeconomics method .

偶数组：B组（传统术后用药组）。A组50例，选用头孢噻肟钠与替硝唑，于手术前30min内单次静脉冲击给药，术中冲洗宫腔、子宫切口及腹腔留置；

Groups A of 50 cases were given tinidazole and cefotaxime sodium in a single intravenous stoss medication in preoperative 30 minutes , douching the uterine cavity and uterine incision during operation , and retaining antibiotics in abdominal cavity postoperatively .

结论：奥硝唑注射液与注射用头孢噻肟钠的配伍液在配伍后4℃8h内、25℃4h内、37℃1h内可使用。

Conclusion : The mixture of ornidazole injection and cefotaxime sodium for injection can be used after ( storing ) at 4 ℃ for 8 h , 25 ℃ for 4 h and 37 ℃ for 1 h.

单次给药中剂量组10h头孢噻肟钠和他唑巴坦钠累计尿排率为49.6±0.58%和80.0±7.0%。

The cumulative urinary excretion rates of cefotaxime sodium and tazobactam sodium were ( 49.6 ± 0.58 ) % and ( 80.0 ± 7.0 ) % after intravenous drip of a single 2.4 g dose , respectively .

结果注射用头孢噻肟钠在各温度条件下于4种包装输液中各检测项目均无明显变化，4组间比较无显著性差异（P0.1）。

RESULTS : No significant change was noted in the detection results of all the items of cefotaxime sodium for injection in 4 kinds of infusion packages and under different temperatures ;

头孢噻肟钠在水-异丙醇中的液固平衡测量与关联

Measurement and Correlation of Liquid-Solid Equilibrium of Cefotaxime Sodium in Water-Isopropanol

头孢噻肟钠治疗新生儿败血症86例临床分析

Clinical Analysis of Cefotaxime Sodium Treating 86 Cases of Neonatal Septicemia

结论：头孢噻肟钠治疗细菌性肺炎较佳。

CONCLUSION : Cefotaxime was the optimal treatment for bacterial pneumonia .

头孢噻肟钠致药疹15例

15 cases of drug eruption induced by application of cefotaxime sodium

注射用复方头孢噻肟钠的临床疗效观察

Clinical Observation for the Curative Effect Compound Cefotaxime Sodium for Injection

甲硝唑对头孢噻肟钠蛋白结合影响的研究

Study on the Effect of Metronidazole on Protein-Binding of Cefotaxime

人牙周膜成纤维细胞对头孢噻肟钠的跨膜转运

Biological transport of cefotaxime sodium by human periodontal ligament fibroblasts

注射用头孢噻肟钠的细菌内毒素定量检测

Quantitative Test of Bacterial Endotoxins in Cefotaxime Sodium for Injection

不同配比头孢噻肟钠/他唑巴坦钠的体外抗菌作用

In vitro antibacterial activities of different ratios from matching cefotaxime / tazobactam

包裹性积液注入糜蛋白酶或头孢噻肟钠。

Chymotrypsin and cefotaxime sodium were injected into the encapsulated pelvic effusion .

头孢噻肟钠生产废渣资源化

RESOURCE The Reuse of Dregs Generated in Cefotaxime Sodium

卵巢单纯性囊肿注入无水乙醇或无水乙醇+头孢噻肟钠；

Ethanol or ethanol plus cefotaxime sodium was injected into the simple cysts ;

注射用头孢噻肟钠的含量测定及体外抗菌活性检查

Determination of cefotaxime sodium injection by HPLC and in vitro antibacterial activity assay

目的测定肾替代治疗的烧伤患者肾脏透析排出液中头孢噻肟钠的含量。

OBJECTIVE To determine Sodium cefotaxime in renal dialysate from burn injured patients .

结论注射用头孢噻肟钠他唑巴坦钠是一种很有发展前途的抗感染的药物。

Conclusion Cefoperazone sodium and tazobactam sodiun for injection are promising anti-infection drugs .

目的：观察注射用头孢噻肟钠、他唑巴坦钠稳定性。

Objective Study on the stability of cefotaxime sodium tazobactam sodium for injection .