恶性疟

江门市输入性恶性疟病例防治情况分析

Analysis on the Control of Imported Malignant Malaria in Jiangmen City

巴基斯坦回国人员中发生多例恶性疟的调查

Investigation and Disposal for Imported Malignant Malaria Cases among Returned Personnels from Pakistan

重复序列DNA探针分析我国恶性疟原虫虫株

Differentiation of Plasmodium falciparum isolates from China with a repetitive DNA probe

磺化标记的DNA探针用于检测恶性疟感染的评价

Evaluation of Sulfonated DNA Probe ( Sulfoprobe ) for Diagnosis of Plasmodium falciparum

各型疟疾患者补体C3含量也有不同程度下降，仍以恶性疟明显（P<0.01）。

The level of C_3 in patients with malaria decreased markedly and the patients with falciparum malaria was significantly lower ( P < 0.01 ) .

通过SDS-PAGE和放射自显影分析恶性疟患者血清抗体的靶抗原。

Immunoprecipitated target antigens of P.falciparum were analysed by SDS-PAGE and autoradiography .

抗恶性疟SERA噬菌体抗体库的构建及单链抗体的筛选与鉴定（英文）

Construction of anti-SERA phage-displayed antibody library and the screen and identification of single chain Fv antibodies ( ScFvs )

DDT滞留喷洒防制雷氏按蚊嗜人亚种控制恶性疟的实验研究

Studies on DDT residual spraying for controlling Anopheles LESTERI anthropophagus and Plasmodium falciparum malaria

目的评价Dipstick和PCR在疟区门诊诊断恶性疟的应用效果。

Aim To evaluate the application of Dipstick and PCR for diagnosing falciparum malaria in outpatient clinics in endemic ares .

方法：以镜检结果为对照，用ICT方法检测门诊四热病人中的恶性疟。

METHODS : With thick blood smear method as control , ICT was used for the detection of P. falciparum .

结果显示，ECL标记的探针能检出25pg纯化的恶性疟DNA或原虫率为0.001%体外培养的恶性疟原虫血，并且和人白细胞DNA无交叉反应。

The results showed that ECL labelled probe successfully detected as little as 25 pg purified DNA or 0.001 % parasitemia of cultured Plasmodium falciparum , and did not react with human leukocyte DNA .

[结论]间日疟和恶性疟混合流行区Pf和Pc两种抗原均可用于人群疟疾抗体的检测，而单纯间日疟地区则以Pc抗原为优。

[ Conclusion ] Both P f and P c antigens could be used in malaria antibody surveillance in mixted endemic areas , while in vivax malaria endemic areas , P c antigen was recommended .

BCG/恶性疟MSP-2、CSP多价疫苗免疫小鼠应答类型研究

Studies on immune response type using BCG vaccination encoding Plasmodium falciparum MSP-2 and CSP in BALB / c mice model

结论：ICT较镜检诊断恶性疟更为快速且简便，更适于在疟区门诊应用。

CONCLUSION : ICT is much more rapid and simple than thick blood smear method for the diagnosis of falciparum malaria , and can be applied in the outpatient clinics in endemic area .

用Pc抗原对间日疟和恶性疟混合流行区的间日疟患者血样进行间接荧光抗体（IFA）试验，以评价其替代Pv抗原检测抗间日疟原虫抗体的效用。

Plasmodium cynomolgi antigen was used for assessment of the effects on detection of antibodies to P. vivax in serum samples from vivax malaria patients in co-endemic areas of vivax and falciparum malaria infections by IFA test .

结论双重PCR用于疟区发热病人检测，较镜检敏感、特异，适合我国恶性疟与间日疟混合流行区的疟疾诊断，还可用于血检质量的监控。

Conclusion The technique of double PCR is more sensitive and specific than microscopy for detection of feverish patients and suitable for detection of mixed infection of falciparum and vivax malaria in additon to the application in the quality control of blood examination of malaria .

疟原虫环子孢子蛋白（CSP）蛋白是平均分布在疟原虫子孢子上的一层表被蛋白，是恶性疟原虫子孢子时期的重要保护性抗原，也是疟疾疫苗研究中的重要候选抗原之一。

Circumsporozoite protein distributed in surface of plasmodium sporozoite ring is one of the most important protective antigens for plasmodium falciparum in sporozoite period . Therefore it is also one of the important malaria vaccine candidates .

序列分析表明，海南省恶性疟原虫虫株的3D7型和K1型的可变区序列与3D7和K1原型序列具有高度同源性。

Sequence analysis showed that the sequences of3D7-and K1-type isolates from Hainan Province were highly homologous to that of3D7 and K1 allelic prototypes respectively .

结果DIGFA对恶性疟和间日疟的检测敏感性分别为95.65%和71.11%，对健康对照者的特异性为97.03%，Youden指数分别为0.93和0.68；

Results The sensitivities of detecting antibody to falciparum malaria and vivax malaria by DIGFA were 95.65 % and 71.11 % , respectively , 95.65 % and 84.44 % by IFAT .

经过15年来对疫点和疫区全民抗复发治疗、外出回归人员药物根治，以及连续3年DDT室内滞留喷洒和6年溴（氯）氰菊脂浸泡蚊帐灭蚊，控制了输入性恶性疟传播蔓延。

After conducting anti-recrudescence treatment for whole people in epidemic focuses and epidemic area , radical cure for migrants for 15 years , indoor residual spray of DDT for 3 consecutive years and decamethrin soaked mosquito nets for 6 years , falciparum malaria had got under control .

1983、1984年的6&7月，连续两次在舒城县庐镇乡进行DDT室内滞留喷洒，第一次喷洒后，嗜人按蚊组成比和叮人率分别下降98.4%和99.5%，恶性疟发病率下降92.1%。

Indoor DDT residual spray was administered consecutively at Lu Zheng township , Shucheng county in June or July , 1983 and 1984 , After the first spray , ratio and bite rate of Anopheles anthropophagus decreased 98.4 % and 99.5 % respectively , p. f. incidence reduced 92.1 % .

结果为FCC1/HN株、12例镜检定为恶性疟和2例混合感染的血样扩增出长度为313bp～320bp的特定Pf60.1基因片段；

The results showed that the FCC1 / HN strain , the samples of 12 falciparum malaria cases and 2 mixed infection cases with both P. falciparum and P. vivax produced 313bp ~ 320bp special gene fragments .

发病特征：间日疟占74.30%，恶性疟占25.70%；

74.30 % were vivax malaria and 25.70 % falciparum malaria ;

恶性疟的两种重组复合抗原的纯化与鉴定

Purification and characterization of two recombinant hybrid antigens of Plasmodium falciparum

青蒿琥酯静脉注射治疗恶性疟的剂量探索

Dosage of Artesunate for Intravenous Injection in Patients with Falciparum Malaria

结论复方蒿甲醚恶性疟的疗效优于组分单药蒿甲醚和本芴醇。

Conclusion The efficacy of co-artemether was than artemether and benflumetolonly .

浙江省永康县输入性恶性疟的监测

Surveillance of imported falciparum malaria in Yongkang county , Zhejiang Province

复方苯芴醇治疗索马里恶性疟的疗效观察

Therapeutic effect of benflumetol compound in patients with falciparum malaria in Somalia

复方蒿甲醚临床治疗恶性疟的效果观察

Clinical efficacy of co - artemether in the patient with falciparum malaria

安徽省恶性疟流行与防治的研究

Study on epidemic and control of Plasmodium falciparum in Anhui