核心组蛋白

本实验通过一种组蛋白去乙酰化酶抑制剂TSA来诱导不同时期胚胎核心组蛋白高乙酰化，观察其对早期胚胎发育能力及相关基因mRNA表达水平变化的影响。

Trichostatin A ( TSA ), one of the inhibitors of HDACs , was used to determine the effects of core histone hyperacetylation on development ability and expression level of relational gene mRNA in different developmental embryos .

组蛋白乙酰转移酶（HATs）通过对核心组蛋白进行乙酰化修饰来调节组蛋白的乙酰化水平，从而调控基因的转录，参与基因的表达，并由此介导基因的激活或沉默。

The level of histone acetylation is regulated by the histone acetyltransferase ( HATS ) with the acetylation modification of core histone . This further control gene transcription and gene expression regulation which resulted in gene activation or silence .

喂服棉酚后的RPS，其精子特异蛋白BP和X1以及核心组蛋白H（2A）和H4有明显的减少。

In the RPS , the synthesis of sperm-specific proteins ( BP and X_1 ) and core histones ( H_ ( 2a ) and H_4 ) reduced markedly .

真核细胞中，核小体是染色质的基本单位，它由两个拷贝HA、HB、H和H所组成的核心组蛋白八聚体，及缠绕于其上的bpDNA构成。

In eukaryotic cells , the fundamental unit of chromatin is nucleosome , which is composed of a histone octamer with two copies of HA , HB , H and H and base pairs of DNA .

CENP-A作为着丝粒染色质的表观遗传学标记，是染色质核心组蛋白H3在着丝粒上的特异变体。

As a epigenetic mark for the centromeric chromatin , CENP-A is a histone H3-like protein specific to centromeres .

结论：SB使NB4、HL-60、U937细胞核心组蛋白乙酰化程度增加，染色质重塑，有利于CREB等转录因子的活化并与DNA结合，促进CD86转录增强，表达增多。

Conclusion : SB can improve the acetylation states of acute leukemia cells , remodel the chromatin which contributes to the binding on DNA of transcription factors , such as CREB and then promote the transcription and expression of CD86 .

H4是真核细胞中最保守的一种核心组蛋白，从真菌到人类的组蛋白H4，其乙酰化只限制在四个赖氨酸上（残基5、8、12和16）。

H4 is the most conservative core histone in eucaryotic cells , ranging from fungi to man , and its acetylation is restricted only to the four lysines ( residues 5,8,12 , and 16 ) .

核心组蛋白分子过乙酰化与慢性阻塞性肺疾病糖皮质激素抵抗

Histone acetylation related to corticosteroid resistance in chronic obstructive pulmonary disease

核心组蛋白及染色质组装相关因子的分离、表达及纯化

Isolation , expression and purification of core histones and chromatin assembly associated proteins

基因有序的转录调控是机体细胞维持正常功能的前提，核心组蛋白的乙酰化和去乙酰化与基因调控密切相关。

Gene transcription regulated orderly is the premise of the cells to main normal function .

核小体的形成还需要组蛋白－组蛋白之间，组蛋白－DNA之间的结合反应，这些反应主要发生于核心组蛋白中心结构域，即：组蛋白折叠区域。

Formation of nucleosomes requires extensive histone-histone and histone-DNA interactions occurred mainly within the central histone-fold domain of each core histone .

染色体核心组蛋白分子作为各种炎症因子和炎症信号转导的关键性终端蛋白质分子，具有基因转录开关分子的功能，其活性受组蛋白转乙酰酶/脱乙酰酶（HAT/HDAC）的调节。

Core histone around which DNA is wound plays a key role as a terminal protein of inflammatory signal transduction on gene transcription .

人们很早就注意到，真核细胞中核小体核心组蛋白N-端尾部的乙酰化水平与基因活化密切相关。

It has been known for some time that the acetylation of N-termini of core histones in nucleosome is associated with gene activation .

在真核细胞中，核小体的核心结构组蛋白被DNA紧密缠绕，但是这种紧密的结合有时也可能变得松散，以利于其他蛋白与DNA的结合。

Histone and DNA bind together to form the nucleosome , but this tight binding can loose at some times to facilitate other proteins to interact with DNA .

细胞周期调控机制的核心是一组蛋白激酶。

The core of cell cycle regulation and control mechanism are relative to a group of protein kinase .