核基质

通过与转录因子、核基质结合元件以及DNA间相互作用，核基质结合蛋白在DNA复制、转录、加工修饰等细胞内事件中起着支持和调节的作用。

Through interacting with transcriptional factors , nuclear matrix binding elements and DNA , nuclear matrix binding protein plays a supporting and regulative role on DNA replication , transcription and modification .

抗食管癌核基质单克隆抗体免疫特异性的检测

Detection of Immunological Specificity of Monoclonal Antibody Against Esophageal Carcinoma Nuclear Matrix

核基质成分-拓扑异构酶II与肿瘤耐药

A Nuclear Matrix Member-topoisomerase II and Tumor Multidrug Resistance

Alpha1抗胰蛋白酶核基质附着区增强RNA聚合酶Ⅱ依赖的转录

Alpha 1-antitrypsin Matrix Attachment Region Enhances RNA Polymerase ⅱ - dependent Transcription

兔网织红细胞与K（562）细胞胞质杂交体（K-RRneo）核基质-中间纤维体系的研究

Nuclear matrix-intermediate filament scaffold of cybrid cells crossed between rabbit reticulocytes and k_ ( 562 ) cells

核基质附着区是一种真核生物的DNA元件，能调控染色体结构和活性。

Eukaryotic DNA element called Matrix Attachment Regions ( MARs ) can function on regulating the structure and activity of chromosome .

利用PCR技术扩增了牛乳腺核基质附着区，全长1190bp。

Bovine mammary matrix attachment regions was cloned from bovine genomic DNA , it was about 1 190 bp .

目的：建立组织原位核基质（NM）制备法。

Objective : To establish a method of prepared tissue in situ nuclear matrix ( NM ) .

核基质MINTN端片段（365-1084aa）相互作用蛋白的筛选及鉴定

Screening and Identification of Nuclear Matrix Protein MINT N-terminal Fragment ( 365-1084 aa ) Interacting Proteins

人膀胱移行细胞癌EGFR基因片段与核基质蛋白的相关性

Correlation between EGFR Gene Fragments with Nuclear Matrix Proteins in Bladder Cancer

其98%以上为蛋白质，这些蛋白质即为核基质蛋白（nuclearmatrixprotein，NMP）。

More than 98 percent of residual component of the nuclear is protein , called as nuclear matrix proteins ( NMPs ) .

SLE患者淋巴细胞核基质蛋白的变化及临床意义

Changes and Clinical Significance of Nuclear Matrix Protein in Lymphocytes of Patients with SLE

研究表明：核基质与DNA的复制、转录、修复等一系列事件具有密切的关系。

A lot of researches showed that a serial events such as DNA replication , mRNA transcription and repair occur in close association with the nuclear matrix .

研究表明核基质和MARs的结合也是存在选择性的，这种选择性和基因表达密切相关。

The binding between MARs and matrix is selective and the selectivity is related with the gene expression .

核基质蛋白MINT相互作用分子的筛选

Screening of Molecules Interacting with Nuclear Matrix Protein MINT

核基质附着区（matrixattachmentregions，MARs）是与核基质（或核骨架）特异结合的DNA序列，属于非编码序列，富含AT。

Matrix attachment regions ( MARs ) are DNA sequences that bind to the nuclear matrix , which tend to be noncoding sequences and AT rich .

目的：克隆杜氏盐藻核基质附着区（MAR）结合蛋白片段。

Aim : To clone MAR-binding protein cDNA fragment from Dunaliella salina .

以丝素基因为探针进行DNA印迹杂交发现，在5龄后丝腺中丝素基因特异性地和核基质紧密结合，说明核基质与丝素基因的组织特异性表达有关。

Southern blot of nuclear matrix - binding DNAs with the fibroin gene suggested that the nuclear matrix is also the base for efficient replication and tissue-specific transcription of fibroin gene .

为了进一步探索染色体DNA与核基质之间的相互作用，从单细胞真核藻类杜氏盐藻中克隆出了MAR片段。

In order to investigate the interactions between chromosomal DNA and nuclear matrices , we isolated the MARs from unicellular alga Dunaliella salina .

单核基质细胞（MC）的阳性率分别为54.8%、45.2%和9.5%。

Their expression rates in the mononuclear cells ( MC ) were 54.8 % , 45.2 % and 9.5 % , respectively .

结果RANKL在颌骨中心性巨细胞病变中的血管、基质中有强烈表达，某些病变中的部分短梭形单核基质细胞和多核巨细胞的胞膜也为RANKL阳性；

Results RANKL signals were strongly positive in the vascular epithelial cells .

烟草核基质结合（MAR）序列的机理研究和应用

Researches on Mechanism of Nuclear Matrix Attachment Regions ( MAR ) from Tobacoo and Their Application

核基质结合序列（MAR）与基因表达调控

The Potential Role of Nuclear Matrix Attachment Regions ( MARs ) in Regulation of Gene Expression

核基质结合区修饰的附着体载体介导的EGFP基因体外表达

MAR-Modified Episomal Vector-Mediated EGFP Expression in Vitro

方法用双向电泳方法比较了3例正常肝和8例HCC核基质蛋白成分。

Methods Using high resolution two dimensional polyacrylamide gel electrophoresis , the nuclear matrix proteins of 3 normal livers and 8 HCC were compared .

伪狂犬病病毒Ea株诱导牛肾细胞凋亡及核基质蛋白的变化

Induction of apoptosis by pseudorabies virus EA strain in bovine kidney ( mdbk ) cells and the alteration of nuclear matrix protein

结果：胃癌组织与正常组织比较，Mr为30000、28000的核基质蛋白表达量明显减少（P<0.05）；

Results ; The expression quantity of 30 000 , 28 000 nuclear matrix proteins in the gastric cancer tissue decreased significantly when compared with that in the normal gastric tissue ( P < 0.05 ) .

38例骨巨细胞瘤均可检测到PCNA的阳性表达，其阳性表达主要位于单核基质细胞的细胞核内；

The expression of PCNA could be detected in all cases , and the positive staining of PCNA was located in mononuclear stromal cells .

白杨素和它的四乙基二磷酸酯对人宫颈癌Hela细胞增殖和核基质蛋白影响的研究

Effects of Chrysin and Its Tetraethyl Bis-Phosphoric Ester on the Multiplication and Nuclear Matrix Proteins of the Human Cervical Carcinoma Cell Line Hela

异源MAR介导外源基因与家蚕受精卵核基质的体外结合

In vitro Association of Exogenous Gene with the Nuclear Matrix of Bombyx mori Fertilised Eggs Mediated by Heterogeneous MAR