穿心莲内酯

穿心莲内酯在超临界CO2萃取中晶体的形成与生长

Crystal formation and growth of andrographolide in supercritical CO_2 extraction

穿心莲内酯超临界CO2重结晶工艺初探

Primary study on the technology of andrographolide recrystallization by using supercritical CO_2

夹带剂对超临界CO2萃取结晶穿心莲内酯的影响

Influence of entrainers on supercritical CO_2 extracting and crystallizing andrographolide

穿心莲内酯超临界CO2萃取结晶研究

Study on Supercritical Carbon Dioxide Extracting and Crystallizing Andrographolide

响应曲面法建立超临界CO2萃取结晶穿心莲内酯工艺模型

Technology model with response surface methodology for supercritical CO_2 extraction and crystallization of andrographolide

乙酸乙酯协同超临界CO2结晶分离穿心莲内酯的研究

Supercritical CO_2 Cooperated with Ethyl Acetate Crystallizing Andrographolide

压力、温度对穿心莲内酯超临界CO2萃取-结晶的影响

Effect of pressure and temperature on extracting and crystallizing Andrographolide by using supercritical CO_2

穿心莲内酯和脱水穿心莲内酯表观油水分配系数的测定及pH值对其的影响

Determination of Apparent Oil-water Partition Coefficient of Andrographolide and Dehydroandrographolide and Effect of pH on Them

穿心莲内酯W制剂抗炎机制的探讨

The investigation of antiinflammatory mechanism of Andrographolide W praeparatum

利用超临界CO2梯度结晶技术分离纯化穿心莲内酯。

Separation and purifying andrographolide by supercritical carbon dioxide gradient crystallization were made .

NaOH水溶液提取穿心莲内酯工艺研究

Study on Extraction Process for Andrographolide with NaOH Solution

穿心莲内酯与rIL2促进LAK细胞生长及细胞表型变化的研究

Study on Andrographolide with rIL_2 in Promoting LAK Cell Proliferation and Phenotype Change

实验证明穿心莲内酯的电极过程为可逆的逐级电子过程，H2O2可催化该还原峰。

The experimental results show that the electrode reaction of andrographolide is a reversible multistep charge transfer process with adsorptive characteristics .

采用单因素试验法探讨超临界CO2梯度结晶压力、温度、时间对穿心莲内酯纯度的影响，并利用高效液相色谱进行纯度检测。

Effects of gradient crystallizing pressure , temperature and time on the purity of andrographolide were investigated via single factor experiments , and the purity of andrographolide was by HPLC .

穿心莲内酯类化合物的分析研究&Ⅰ.穿心莲内酯（Andrographolide）衍生物的离子对高速液相色谱法分析

Analysis of andrographolide compounds ⅰ . ion pair high performance liquid chromatographic analysis of andrographolide derivatives

穿心莲内酯（Andrographolide，AD）是我国传统中草药穿心莲（Andrographispaniculata）的主要有效成分之一。

Andrographolide ( AD ) is one of the major active constituents from Andrographis [ Andrographis paniculata ( Burm . f ) Nees ] , a traditional Chinese herbal medicine .

应用~（35）硫对NaHSO3-穿心莲内酯代谢的研究

The metabolism of nahso_3-andrographolide studied by means of ~ ( 35 ) s

Beagle犬静脉注射亚硫酸氢钠穿心莲内酯后的药动学行为符合二室模型。

After intravenous injections of 50 , 40 , 20 mg · kg - 1 of andrographolide sodium bisulphite in beagle dogs , the concentration-time curve was fitted to a two compartment model .

方法：不同浓度穿心莲内酯提取物、穿心莲内酯单体分别加入人富含血小板血浆（PRP）中，用多功能血小板聚集仪测定ADP诱导的血小板聚集作用。

Methods : After APN or APN monomer at different concentrations was added into the human platelet rich plasma ( PRP ), the ADP-induced platelet aggregation was measured by using multifunctional platelet aggregometer .

穿心莲内酯（Andro）抗炎机制的研究

Mechanism Study of Andrographolide on Inflammation

穿心莲内酯衍生物DAP-Na的药效学研究

Studies on pharmacodynamics of andrographolide derivative & DAP-Na

考察了单因素参数压力、温度对穿心莲内酯纯度、结晶量等的影响。结果表明：超临界CO2萃取结晶穿心莲内酯的纯度在结晶板上呈梯度分布；

The effects of pressure and temperature on extracting purity and crystallizing amount of Andrographolide were studied ( purity of andrographolide 30 % and 98 % ) in supercritical CO_2 . The results showed that there appeared gradient distribution of crystallization of purity from downside to upside of crystal board ;

本文的研究工作分为两个部分，第一部分研究了新型穿心莲内酯类衍生物抑制α-葡萄糖苷酶活性的三维定量构效关系（3D-QSAR），建立了糖和糖苷酶抑制剂数据库。

This thesis consists of two parts . The first part deals with the 3D-QSAR studies on andrographolide derivatives inhibiting α - glucosidase and foundation of the database of glucides and inhibitors of glucosidase .

目的：利用体外实验研究穿心莲内酯对T细胞行为的影响及其对盲肠结扎穿孔（CLP）诱导的脓毒血症模型的免疫学效应，并探讨其作用机制。

AIM : To investigate the effect of Andrographolide on T Lymphocyte behaviors in vitro , and elucidate the immunoregulation effect of AN on sepsis models induced by cecal ligation and puncture , in order to explore the mechanism of AN . Methods : 1 .

穿心莲内酯对小鼠呼吸道非特异性免疫功能的影响

Effects of Andrographolide on Respiratory Tract Nonspecific Immune Functions of Mice

中药新穿心莲内酯抗中暑内毒素血症作用机制的研究

Study about the Effect and Mechanism of Neoandrographolide Against Endotoxemia

穿心莲内酯衍生物设计合成与抗肿瘤活性研究

Studies on the Syntheses and Anti-tumor Activity of Andrographolide Derivatives

此反应途径为穿心莲内酯在大鼠体内代谢排泄的主要途径。

It may be the main metabolic pathway of Andrographolide in rats .

乙酰穿心莲内酯的制备及其抑菌活性和化感作用比较研究

Preparation of Acetyl Andrographolide and Comparison of Its Antimicrobial Activities and Allelopathic Effects

穿心莲内酯亚硫酸氢钠加成物的结构研究

Studies on the structure of the adduct of andrographolide with sodium hydrogen sulfite