罗红霉素

罗红霉素对哮喘大鼠NF-κB及气道炎症的影响

Effects of roxithromycin on NF - κ B activity and bronchial hyperresponsiveness of asthma rats

HPLC法测定罗红霉素片的溶出度

Development of Dissolution Method of Roxithromycin Tablets by HPLC

HPLC法同时测定复方罗红霉素片中盐酸氨溴索与罗红霉素的含量

HPLC determination of the contents in compound roxithromycin tablets

罗红霉素颗粒和干混悬剂溶出度HPLC测定法的建立

Development of the dissolution methods for roxithromycin granules and roxithromycin for suspension by HPLC

临床上广泛使用的（E）-罗红霉素在人体内有多种代谢途径。

Several metabolic pathways of ( E ) roxithromycin , a widely used antibiotic , were observed in humans .

目的建立罗红霉素软膏含量测定的HPLC方法，并与微生物法的测定结果进行比较。

OBJECTIVE To establish HPLC method for the determination of roxithromycin ointment and compare it with microbiological assay .

罗红霉素对人牙周膜成纤维细胞TNF-α、IL-6释放的影响

Effects of roxithromycin on TNF - α and IL-6 release from periodontal ligment fibroblasts stimulated with lipopolysaccharide

罗红霉素对小鼠腹腔巨噬细胞产生IL-8的影响

The effect of roxithromycin on IL-8 produced by the macrophage in abdominal cavity of mice

Azithromycin胶囊剂与罗红霉素片剂随机对照治疗急性感染比较

A comparative study of azithromycin versus roxithromycin in the treatment of acute infection

结果：罗红霉素含量测定平均回收率为99.19%，RSD为0.46%。

Results : Average rate of recovery of roxithromycin ointment was 99 . 19 % , RSD - 0 . 46 % .

将新的TLC法用于罗红霉素的有关物质及分解产物检查，结果令人满意。

Good results were obtained when the novel TLC method was used in the examination of the related substance or degradation products in roxithromycin .

方法：用微生物法测定10名男性健康志愿者分别口服罗红霉素干混悬剂和片剂各150mg后的血药浓度，以观察罗红霉素干混悬剂的相对生物利用度。

METHODS : The study was conducted in 10 male volunteers .

建立了罗红霉素新的TLC法，并与《日本抗生物质医药品基准解说》1993年版收载的方法进行了比较。

A novel TLC method of roxithromycin was compared with the TLC method which was described in The Japanese Standards of Antibiotics ( 1993 ) .

方法20名志愿者单剂量口服150mg的罗红霉素肠溶胶囊，采用LC-MS法测定其血清中罗红霉素浓度。

Methods 20 male healthy subjects received a single dose of 150 mg roxithromycin enterosoluble capsules .

目的：研究罗红霉素（RM）与桔梗联合应用后，桔梗对罗红霉素药代动力学性质和肺中药物浓度的影响。

Objective : To study the effect of Chinese herb Platycodon grandiflorum on roxithromycin pharmacokinetics in blood and drug concentration in lung tissue .

结果：20mg·kg-1罗红霉素效应相灌胃给药明显抑制2,4,6三硝基氯苯诱导的小鼠接触性皮炎（P<0.01）。

RESULTS : Roxithromycin 20 mg · kg - 1 significantly suppressed contact sensitivity induced by picryl chloride in mice .

国产罗红霉素对于所采用实验菌株的MBC要大于MIC的4～16倍。

The minimal bactericidal concentration ( MBC ) of roxithromycin was4 ~ 16 times greater than the minimal inhibitory concentration ( MIC ) .

HPLC-UV法用于人血浆中罗红霉素的浓度测定及药代动力学和生物等效性研究

HPLC-UV Method for Determination Concentration of the Roxithromycin in the Human Plasma and Study of Pharmacokinetic and Bioequivalence

方法以微生物法测定8只Beagle犬服用罗红霉素普通片和缓释片后的血药浓度，计算出有关药动学参数，经统计学分析对缓释片生物利用度进行评价。

METHODS : Microbiological method was used to determine the serum concentration of roxithromycin after normal and sustained-release tablets were orally administrated in 8 healthy beagle dogs .

报道了罗红霉素颗粒剂在高温、高湿及光照条件下放置10天，及40℃，75%湿度放置3个月，考察其外观、pH值、水分及含量，结果表明本品稳定性较好。

The characteristics , pH , Water and Assay of Roxithromycin Granules were measured under high temperature , high humidity and light radiation for 10 days ; 40 ℃, 75 % humidity for three months . Results showed that Roxithromycin Granules have good stability .

以琼脂对倍稀释法测定新大环内酯类抗生素（azithromycin、clarithromycin及罗红霉素）等抗菌药对202株临床分离菌的最低抑菌浓度。

The in vitro activities of new macrolides ( azithromycin , clarithromycin and roxithromycin ) and other antimicrobial agents against 202 clinical isolates were tested using agar dilution method .

罗红霉素为半合成的大环内酯类抗生素，通过与敏感细菌核蛋白体的50s亚基结合，抑制蛋白质的合成，从而起到抗菌作用。

Roxithromycin ( RXM ), as a semisynthetic macrolide antibiotics , could disrupt bacterial protein synthesis by combining with 50s bacterial subunit , thereby exhibited antibacterial effects .

结论：提示交沙霉素、强力霉素、左旋氧氟沙星、罗红霉素分别可作为治疗广西地区妇女UU、MH及UU、MH混合感染的首选药物。

Conclusion : Our data suggested that josamycin , doxycycline , levofloxacin and roxithromycin might be the first-choice drugs to treat cervicitis patients caused by UU , MH and UU-MH-mixed infections respectively in Guangxi area .

6例脓癣病人加服罗红霉素（病人体重24～40kg者100mg，bid；12～23kg者50mgbid）及外用莫匹罗星软膏，bid。

Six kerion patients were given roxithromycin ( 24 ~ 40 kg : 100 mg , bid ; 12 ~ 23 kg : 50 mg bid ) and mupirocin ointment for treatment .

结果：雏鸡口服罗红霉素的药时数据符合一级吸收二室模型，低剂量加桔梗组（8mg／kg）的C（max）值显著高于单用RM组（P＜0.05）；

Results : The blood concentration-time data roxithromycin in plasma fitted to two compartment model with 1st order absorption . The Cmax values of the experimental groups were significantly higher than those of the control groups , respectively ( P < 0.05 ) .

方法20名健康成年男性志愿者采用随机分组自身交叉对照试验设计，单剂量口服150mg罗红霉素片后，用液质联用（LC-MS）法测定血浆中药物浓度。

Methods 20 male healthy volunteers randomly received a single crossover oral dose of 150 mg test tablet or reference tablet . The concentration of roxithromycin in plasma was determined by LC-MS.

应用固相萃取（SPE）及LC-MS/MS技术，建立了水中痕量大环内酯类抗生素即红霉素、脱水红霉素、罗红霉素的分析方法，优化了固相萃取、液相色谱-质谱/质谱等相关条件。

The determination of macrolide antibiotics in water was performed using solid phase extraction ( SPE ) followed by a combined liquid chromatography ( LC ) and tandem mass spectrometry ( MS / MS ) procedure under the multi-reactive model .

罗红霉素（RXM）是一种广泛应用的大环内酯类抗生素，其抗菌谱与红霉素相似，对革兰氏阳性菌有强大的抗菌作用。

Roxithromycin is a widely-used antibacterial macrolide , which has an antibacterial spectrum in vitro similar to that of erythromycin , with strong activity against Gram-positive bacteria .

研究了以无水碳酸钠为催化剂，红霉素肟与甲氧基乙氧基氯甲醚（MEMC）为原料，一步合成罗红霉素的实验过程。

The experimental process on synthesis of roxithromycin was studied by using erythromycin oxime and MEMC as raw material under the catalytic action of anhydrous sodium carbonate .

中介率增幅大，经x2检验（P<0.01）有统计意义的是：阿齐霉素、氧氟沙星、罗红霉素，分别由18.0%升至37.2%、26.5%升至39.6%、13.3%升至22.0%。

There was a big rate of increase amplitude of the mesomeric rate , and through x2 assay ( P ﹤ 0.01 ) the statistically significant are azithromycin ? ofloxacin ? roxithromycin , they increased from 18.0 % to 37.2 % ?