药物代谢酶

药物代谢酶、转运体及药物作用靶点存在着的基因多态性与药物疗效和毒性的个体差异有很大关系。

The genetic polymorphism of drug metabolizing enzyme , transporter and target greatly influence the individual difference of drug efficiency and toxicity .

药物代谢酶基因分型芯片关键技术及应用研究

Study on Key Techniques and Application of Genechip for Drug Metabolizing Enzyme Genotyping

药物代谢酶及转运体与前列腺癌药物治疗蛋白激酶C在肾细胞癌多药耐药中的作用

Drug-Metabolizing Enzymes and Transporters : Roles in the Human Prostate Cancer Chemotherapy

结论：ASP具有调节肝脏药物代谢酶活性作用。

Conclusion : ASP can modulate the activities of drug metabolism enzymes .

植物药及果蔬对药物代谢酶P450活性的影响

Effect of Plant Drug , Vegetable and Fruit on The Activity of The Cytochrome P450

目的探讨药物代谢酶在维生素E琥珀酸酯（VES）抑制苯并（a）芘毒性中的作用。

Objective To study the role of the pharmaceutical metabolism enzyme during the inhibitory effect of VES against B ( a ) P in mice .

目的研究18α甘草酸二铵（18αGL）对肝脏药物代谢酶的影响。

AIM To study the effect of 18 α glycyrrhizic acid ( 18 α GL ) on hepatic microsomal drug metabolizing enzymes in rats .

目的：研究和探讨吸烟所致宫内发育迟缓（IUGR）大鼠母体肝脏药物代谢酶活性和抗氧化功能的改变及其所带来的毒理学和药理学意义。

AIM : To evaluate the alterations of maternal hepatic drug-metabolizing enzymes and antioxidative function in tobacco-induced intrauterine growth retardation ( IUGR ) .

阐述了药物代谢酶细胞色素P450（CYP450）在药物配伍的复杂相互作用体系中的重要作用；

It expatiated on the significance of the metabolic enzyme CYP 450 in the interaction of compatibility of Chinese Herbs .

探讨免疫性肝损伤对肝脏细胞色素P450药物代谢酶系（CYP450）的影响及免疫损伤条件下NO在CYP450药物代谢酶系活性调节中可能的作用机制。

To study the effect of immune damage in liver on cytochrome P450 metabolism enzymes ( CYP450 ) and the possible mechanism .

目的本研究旨在观察沙坦类药物代谢酶CYP2C9和反应受体AT1的遗传多态性在高血压患者中的分布特征。

Objective To investigate the genetic polymorphism of sartan drug metabolic enzyme CYP2C9 and angiotensin AT1 receptor in hypertensive patients .

目的：观察当归总多糖（ASP）对正常及泼尼松龙（PSL）所致肝损伤小鼠肝脏药物代谢酶活性的影响。

Objective : To study the effects of Angelica sinensis Polysaccharides ( ASP ) on the hepatic drug metabolism enzymes activities in normal mice and those prednisolone ( PSL ) - induced liver injury .

目的：探讨药物代谢酶N-乙酰化转移酶1（NAT1）基因多态性在中国人群中的分布及其与炎症性肠病（IBD）的相关性。

Objective : To assess the association between the genetic polymorphisms of N-acetyltransferase-1 ( NAT1 ) and NAT1 susceptibility to inflammatory bowel disease ( IBD ) .

HBx基因的整合及AFB1的攻击可能通过影响DNA修复系统、药物代谢酶系统及细胞色素P450（CYP）代谢酶基因的异常表达导致肝癌的发生。

The integration of HBx gene and the attack of AFB_1 may induce hepatoma by influencing the system of DNA repair , the system of drug-metabolizing enzymes and the expression of cytochrome P450 ( CYP ) genes .

目的探讨氟尿嘧啶类药物代谢酶&胸苷酸合成酶（TS）、胸苷磷酸化酶（TP）和二氢嘧啶脱氢酶（DPD）表达水平与人胃肠道肿瘤细胞化疗敏感性的关系。

Objective To probe the relationship between the chemosensitivity of 7 gastrointestinal cancer cell lines and the expression levels of metabolic enzymes of fluoropyrimidines including thymidylate synthase ( TS ), thymidine phosphorylase ( TP ), and dihydropyrimidine dehydrogenase ( DPD ) .

一些中草药可能诱导或抑制肝脏细胞色素P450（CYP）药物代谢酶，从而引起自身及其他合用药物代谢的改变，可能导致药物不良反应和药物相互作用。

Like synthetic drugs , herbal preparations also have potential to cause drug interactions . Some of these drugs can inhibit or induce liver cytochrome P450 activity . Thereby influence drug metabolism and maybe cause drug adverse action and drug interactions .

Z-Ajo和E-Ajo皆不能透过Caco-2单层细胞而被迅速代谢，其代谢与CYP450药物代谢酶有关。

It is shown that neither Z-ajoene nor E-ajoene can pass through Caco-2 cell monolayers , and that they can be metabolized by the cells . The metabolism might be in correlation with cytochrome P450 drugs metabolism enzymes in Caco-2 cell monolayers .

GSTs是一组多功能Ⅱ相药物代谢酶，它的过表达是导致癌细胞产生化疗耐药性的因素之一，肿瘤细胞可通过表达GSTs而保护自身免受抗肿瘤药物的损害，从而降低抗肿瘤药物疗效。

GSTs are a group of phase ⅱ drug metabolism enzymes . Overexpression of GSTs is one of the important factor for producing chemoresistance , tumour cells can protect themselves against anti-tumour drugs and reduce curative effect of anti-tumour drugs by express GST .

日本血吸虫感染对小鼠肝药物代谢酶的影响

Effect of Schistosoma japonicum infection on liver drug-metabolizing enzymes of mice

辛伐他汀对大鼠肝微粒体药物代谢酶活性的影响

Effects of Simvastatin on Drug-metabolizing Enzyme of Liver Microsome in Rats

冰片单次和多次给药对肝脏微粒体药物代谢酶的影响

Influence of Borneolum Syntheticum on Cytochrome Enzymes in Liver Microsome

氧化苦参碱对小鼠肝微粒体药物代谢酶的诱导作用

Inducing Role of Oxymatrine on the Hepatic Microsomal Drug-metabolism Enzyme in Mice

中药有效成分对药物代谢酶的影响

Effects of the Active Components of Some Chinese Herbs on Drug Metabolizing-enzymes

非甾体抗炎药药物代谢酶多态性的研究进展

Progress in polymorphic drug - metabolizing enzymes of NSAIDs

当归总多糖对小鼠肝脏药物代谢酶活性具有调节作用

Effects of Angelica sinensis Polysaccharides on Hepatic Drug Metabolism Enzymes Activities in Mice

人工感染猪链球菌对小鼠肝脏药物代谢酶的抑制作用

Inhibition of Hepatic Drug-Metabolizing Enzymes in Mice During Streptococcus suis Type 2 Infection

目的：为了促进药物代谢酶在临床上的深入研究。

Objective : To promote the study of drug metabolic enzymes in clinical practice .

液化石油气燃烧颗粒提取物对大鼠肝、肺药物代谢酶的诱导

The induction of Pulmonary and Hepatic Drug-Metabolizing Enzymes by LPG-burner Particulate Extracts in Rats

药物代谢酶基因多态与肝癌关系研究

Study of Relationship Between Genetic Polymorphisms of Drug Metabolizing enzymes and Susceptibility to Hepatocellular Carcinoma

肿瘤化疗与药物代谢酶

Cancer Chemotherapy and Drug Metabolism Enzyme