光老化

HIPS/纳米TiO2的分散及光老化性能研究

Study on dispersion and light aging properties of hips / nano-tio_2

主要研究了高聚合度聚氯乙烯（HPVC）的热稳定性和热分解过程以及光老化对HPVC性能的影响。

The heat stability , thermal decomposition behavior and the effect of light aging on performance of HPVC were studied .

光老化皮肤中弹性纤维、胶原纤维的变化和AGEs的表达

Alteration of Elastic 、 Collagen Fibers and Expression of AGEs in Cutaneous Photoaging

皮肤光老化机制研究&紫外线照射对成纤维细胞染色体端粒DNA复制的影响

Investigation of Skin Photoaging Mechanisms-Influences of Ultraviolet Irradiation on the Telomere Length of Chromosome in Primary Cultured Human Fibroblast

和紫外线B不同，紫外线A几乎不会引起明显的晒伤，但会引起光老化，也有可能导致皮肤癌。

These rarely trigger obvious sunburn , unlike UVB rays , but cause most photo-ageing , and can also lead to skin cancer .

目的探讨皮肤光老化与真皮成纤维细胞线粒体DNA复制控制区点突变的关系。

Objective To investigate the relationships between skin photoaging and point mutations in mitochondrial DNA ( mtDNA ) control region for replication of dermal fibroblast .

近年来研究表明活性氧簇（ROS）在UV致皮肤光老化过程中起重要作用。

It is demonstrated by the fact that reactive oxygen species play a major role in photoaging .

目的初步探讨丁羟甲苯（BHT）是否对紫外线（UV）所致皮肤光老化有保护作用。

Objective To preliminarily observe whether BHT has the protective effect on skin photoaging .

结论CO2点阵激光能有效治疗面部皮肤光老化，且安全性高、不良反应少，恢复时间短。

Conclusion CO2 laser lattice light had an effect on treating facial skin aging , with safety , few side effects and shorted recovery time .

UVB辐射表皮角质形成细胞和UVA辐射真皮成纤维细胞在皮肤光老化中的作用机理研究

Study of Mechanism of UVB-irradiated Epidermal Keratinocytes and UVA-irradiated Dermal Fibroblasts in Skin Photoaging

每2周观察组织学、过氧化及抗氧化指标MDA、SOD，羟脯氨酸含量等，评价光老化造模效果。

Observe the histological appearance , peroxide and antioxidant indexes of MDA / SOD , hydroxyproline contents every two weeks to evaluate the effects of photoaging model .

目的观察CO2点阵激光治疗面部皮肤光老化的临床疗效及副作用，并总结其临床治疗经验。

Objective To observe the clinical efficacy and side effects of treating the facial skin photoaging by the CO2 lattice laser and sum up the clinical treatment experience .

结果是以氧气为介质的PBO纤维光老化的效果最为明显。

The results showed that the fiber aged in the oxygen medium has the most decrease of properties .

用人工老化的方法比较了羧酸酯稀土和有机锡对聚氯乙烯（PVC）的光老化稳定作用。

Light ageing properties of poly ( vinyl chloride )( PVC ) by the carboxylic ester rare earth salt and the organotin have been compared by artificial ageing test .

研究了纳米TiO2粒子在高抗冲聚苯乙烯（HIPS）/纳米TiO2复合材料中的分散及纳米TiO2对复合材料光老化性能的影响，探讨了复合材料的光老化机理。

The dispersion of TiO 2 nanoparticles , mechanical properties , light aging properties and light aging mechanism of HIPS / nano-TiO 2 composites were studied .

人参皂苷Rb1与芳维甲酸乙酯对光老化皮肤真皮成纤维细胞基质金属蛋白酶影响的比较研究

Comparative Study of the Effect of the Ginsenoside Rb_1 and Arotinoid Ethyl Ester on the Expression of MMPs in Sun-induced Aging Dermis Fibroblasts

MMPs可降解绝大部分细胞外基质（ECM），是皮肤光老化的直接原因。

MMPs can degradable most of the extracellular matrix ( ECM ), which is the direct cause of photoaging of the skin .

本实验结果证实，BMSCs能够延缓皮肤光老化的发展进程，对光老化的发生具有预防作用。

Results of this study confirmed that BMSCs can delay the development of photoaging process , BMSCs still have preventive role on photoaging . 4 .

紫外线中的长波紫外线（UVA）与人体皮肤光老化发生关系密切，在皮肤光老化的研究日显重要。

The ultraviolet A ( UVA ) in ultraviolet light is closely related to human skin photoaging and has attracted worldwide attention .

背景：紫外线A（ultravioletA，UVA）照射皮肤可产生红斑等急性炎症反应，导致皮肤光老化、皮肤光敏作用和多种皮肤疾病的发生，甚至诱发皮肤癌。

Background : Ultraviolet A ( UVA ) radiation can lead to acute inflammation ( such as erythema ), photoaging , photosensitization , skin diseases , and skin cancer .

虽然UVB进入真皮的数量远少于UVA，但因其损伤强度大，且光老化是一个紫外线长期辐射累积的结果，UVB对真皮成纤维细胞造成的损伤也不容忽视。

Photoaging was a result of long-term ultraviolet accumulation and UVB could also produce a marked effect although its quantity was less than UVA into dermis .

皮肤光老化的分子机制之一，是UVA和UVB通过激活细胞信号转导通路诱导表皮角质形成细胞和真皮成纤维细胞MMPs的基因转录。

One molecular mechanism of skin photoaging is that UVA and UVB induce MMPs gene transcription of epidermal keratinocytes and dermal fibroblasts through activating cellular signal transduction pathways .

虽然其发生机制尚未完全明了，但是基质金属蛋白酶（Matrixmetalloproteinases，MMPs）增高导致纤维结缔组织的降解是引起皮肤光老化最重要的机制。

Although its mechanism is not yet fully understood , but the most important mechanism that causes skin photoaging is that the increased matrix metalloproteinases ( MMPs ) lead to the degradation of fibrous connective tissue .

背景和目的：皮肤长期暴露于日光紫外线可出现光老化（photoaging）。

Background and Aims : Chronic solar ultraviolet exposure causes photoaging of skin , a process that is characterized by wrinkles , loss of skin tone and resilience .

第五部分选择在光老化信号传导途径中发挥重要作用的c-jun作为靶点，用反义ODN抑制其转录表达，进一步探讨UVB辐射的信号传导。

C-jun is a key point in the signal transduction of ultraviolet irradiation . So in part V the inhibition mechanism of antisense c-jun ODN on MMP expression induced by UVB was explored .

基质金属蛋白酶组织抑制物-1（TIMP-1）是MMPs的特异性内源性抑制物，能够抑制MMPs的活化与表达，从而阻止光老化的发生。

Tissue inhibitor of Matrix Metalloproteinase-1 ( TIMP-1 ) mRNA is the specificity of the endogenous inhibitor of MMPs , which can inhibit MMPs activation and expression , and then prevent the occurrence of photoaging .

结论PUVA治疗引起的皮肤光老化皱纹形成可能与真皮成纤维细胞基质金属蛋白酶及其组织抑制剂表达失衡密切相关。

Conclusion Wrinkle formation in photoaging skin after PUVA therapy is correlated with the imbalance of expression of matrix metalloproteinases and their inhibitors of dermal fibroblasts .

已有研究证明紫外线辐射后诱导人类皮肤成纤维细胞产生基质金属蛋白酶（Matrixmetalloproteinases，MMPs），MMPs能特异性降解几乎所有的细胞外基质成分，在皮肤光老化中起着重要作用。

It has been proved that UV irradiation could promote the human fibroblasts generate matrix metalloproteinases ( MMPs ), MMPs could specifically degrade almost all of the extracellular matrix component , which plays an important role in the skin photoaging .

在加速光老化实验条件下，研究超细二氧化钛、超细氧化锌、抗菌沸石（ZA）和乙烯-醋酸乙烯酯共聚物（EVA）对聚丙烯纤维光降解性能的影响。

The influence of different additives of ultrafine titanium dioxide , ultrafine zinc oxide , Zeolite-Ag ( ZA ) and ethyl-ene-vinyl acetate ( EVA ) on the photo-oxidative degradation of polypropylene fiber was studied under the accelerated aging test conditions .

结论：在模拟日光照射致小鼠皮肤光老化模型中，茶多酚、茶色素均能提高皮肤组织T-AOC、SOD活力，降低组织MDA含量，改善小鼠真皮弹性纤维的病变；

Conclusion : In the present study both tea polyphenols and tea pigments administered by gavage or topically could significantly enhance the level of T-AOC and SOD , and reduce the content of MDA , and ameliorate lesions of elastic fibers of dermis .