全基因组关联分析

类风湿关节炎易感基因的全基因组关联分析研究进展

Identifying susceptible genes of rheumatoid arthritis by genome-wide association study : an advance

为克服其缺陷，有必要利用海量分子标记进行全基因组关联分析。

To overcome these shortcomings , it is necessary to carry out genome-wide association studies ( GWAS ) with high throughput SNP markers .

用传统的家系连锁分析无法对精神分裂症这样的复杂疾病进行基因定位，而全基因组关联分析则为最终发现这些基因提供了较好的策略。

After linkage analysis failed to locate susceptible genes of complex diseases like schizophrenia , it is a better way to process whole - genome association studies .

然而，全基因组扫描和关联分析等研究发现在HLA以外的区域仍存在AS的易感区域，大量的证据显示在HLA区内外有许多基因与AS的发病有关。

However , genome-wide scan and association studies have shown , in addition to HLA , regions outside the HLA are involved in susceptibility to AS . Furthermore , there is compelling evidence that non-B27 genes , either within or outside the HLA , are involved in disease aetiology .

近年来，大量研究表明在表型评价的基础上，应用全基因组学进行基因关联分析是鉴定和分离抗病基因的有效手段。

And on basis of phenotype evaluation , whole genomics which was used to gene association analysis had been an effective method for disease resistance gene isolation and identification .