加替沙星

注射用加替沙星与维生素B6配伍稳定性考察

Study on compatible stability of gatifloxacin for injection and vitamin B_6 injection

Cr~（6+）对加替沙星与小牛胸腺DNA相互作用的影响

Influence of Cr ~ ( 6 + ) on Binding of Gatifloxacin with DNA

用HPLC方法研究了加替沙星氯化钠注射液的稳定性。

The stability of gatifloxacin sodium for injection was performed by HPLC .

HPLC法测定注射用头孢替唑钠的含量及其有关物质注射用加替沙星与头孢美唑配伍的稳定性考察

Determination of Ceftezole Sodium for Injection and Its Related Substances by HPLC

头孢尼西钠与加替沙星注射液配伍稳定性考察HPLC法测定阿魏酸钠氯化钠注射液的有关物质

Determination of related substances in sodium ferulate and sodium chloride injection by HPLC

加替沙星眼用凝胶剂的HPLC测定

Determination of Gatifloxacin Ophthalmic Gel by HPLC

建立了HPLC法测定加替沙星眼用凝胶剂含量及有关物质。

A HPLC method for determination of gatifloxacin and its related substances in ophthalmic gel was established .

加替沙星对老年COPD患者茶碱群体药代动力学的影响

The effect of Gatifloxacin on population pharmacokinetics of Theophylline in the elderly COPD patients

RP-HPLC测定加替沙星滴眼液的含量

Determination of Gatifloxacin in Gatifloxacin Eye Drops by RP-HPLC

目的建立HPLC测定大鼠肝、肾、肺、脾、心等组织内加替沙星的药物浓度。

Objective To establish HPLC method for determination of gatifloxacin in rats tissues including liver , kidney , lung , heart .

用琼脂稀释法测定对环丙沙星、左氧氟沙星、加替沙星的最小抑菌浓度（MinimalInhibitoryConcentration，MIC）。

The minimal inhibitory concentration ( MIC ) of ciprofloxacin , levofloxacin , gatifloxacin was measured by using agar dilution method .

加替沙星PLGA生物可降解缓释微球的研究

Study on Sustained Release PLGA Microsphere with Biodegradation of Gatifloxacin

加替沙星注射液光降解产物的LC-MS分析

Photodegradation product analysis of gatifloxacin injection by HPLC-MS

应用紫外和荧光分光光度法研究加替沙星对大鼠肝微粒体细胞色素P450酶活性的影响；

The effects of gatifloxacin on mice hepatic microsomal enzymes ( CYP450 ) were study by spectrophotometer .

此外，本论文还开展了基于BDD薄膜电极的电化学免疫传感器对加替沙星的电化学检测研究。

In addition , an immunosensor based on BDD films for detection of gatifloxacin was also investigated .

方法：对浙江省药品不良反应监测中心近三年来收集的674例加替沙星ADR报告进行Excel列表分析。

METHODS : 674 ADR cases induced by gatifloxacin collected in the Center of ADR Monitoring of Zhejiang Province during the recent three years were analyzed with Excel .

LSS法估算COPD患者茶碱缓释片单用及联用加替沙星时稳态药-时曲线下面积

Estimation of the area under curve of steady-state concentrations of theophylline single oral taken and concurrent with gatifloxacin in COPD patients by limited sampling strategy

目的：分析加替沙星不良反应（ADRs）的发生规律和特点，为临床选用药及药物安全评价提供依据。

Objective Analyzing the regularity and characteristic of the adverse reactions ( ADRs ) of Gatifloxacin is helpful for clinical medication and medicine security .

结论：甲磺酸加替沙星具有口服后吸收快、血药浓度较高、体内平均滞留时间（MRT）较长的特点；

CONCLUSION : The gatifloxacin mesylate has characteristic of quick absorption , high peak concentration in plasma and longer mean retention time ;

结果：加替沙星对葡萄球菌属的MIC90比其他4种氟喹诺酮类药物低。

RESULTS : The MIC 90 of gatifloxacin against staphylococcus species was lower than the other four fluoquinolones .

方法采用3剂量3周期拉丁方实验设计。9名健康受试者单剂口服甲磺酸加替沙星片100、200、300mg，HPLC法测其血清、尿药物浓度。

Method A single-dose of 100,200 , or 300 mg gatifloxacin mesylate were administered orally to nine healthy volunteers in 3 × 3 latin square ; the concentrations of gatifloxacin in serum and urine were detected by HPLC .

方法：采用体外扩散实验考察不同浓度的Trans对利巴韦林、依诺沙星、加替沙星，盐酸左氧氟沙星和奥沙普秦兔角膜透过率的影响。随着pH值的降低，哌仑西平角膜透过率逐渐提高。

METHODS : The effects of Trans on the corneal permeability of drugs were investigated in vitro , using isolated rabbit corneas . The penetration rate was found to dependent on the pH of pirenzepine solution . The lower the pH , the higher the rate .

结论：健康受试者单次静滴甲磺酸加替沙星氯化钠注射液，最大剂量至800mg，比较安全，耐受性较好。

CONCLUSIONS The single dose intravenous infusion to the Chinese healthy volunteers up to 800 mg of gatifloxacin mesilate is safe and tolerable .

目的研究加替沙星阴道泡腾栓（GVES）的药效学。

Objective To study the pharmacodynamics of gatifloxacin vaginal effervescent suppository ( GVES ) on the guinea pigs .

目的：考察甲磺酸加替沙星（GFLX）对小鼠非特异性免疫防御的调节作用。

Objective : To study the immunomodulation of gatifloxacin mesylate ( GFLX ) on non specific immune defence in mice .

目的评价加替沙星治疗社区获得性呼吸道感染（CARTIs）的临床疗效。

Objective To evaluate the treatment effect of gatifloxacin for community acquired respiratory tract infections ( CARTIs ) .

方法：狗口服盐酸加替沙星5,10和20mg/kg后0.25,0.5,0.75,1,2,4,8,12和24h分别从前肢胫前静脉取血，用微生物法测定血药浓度并计算药代动力学参数；

Methods : Following administration of a single dose of 5,10 , and 20mg / kg gatifloxacin HCl to dogs , blood was taken at 0.25,0.5,0.75.1,2,4,8,12 , and 24h and blood drug concentrations were determined by microbiological assay . Then the pharmacokinetic parameters were calculated .

结论克拉霉素本身对铜绿假单胞菌不具有杀菌活性，但1/4MIC、1/16MIC克拉霉素均能减少铜绿假单胞菌BF中的纤维素样物质，破坏生物膜的结构，而增加加替沙星的抗菌活性。

Conclusion : Clarithromycin show no bactericidal activities to Pseudomonas aeruginosa in biofilm . However , both 1 / 4 MIC and 1 / 16MIC clarithromycin can enhance the bactericidal activities of gatifloxacin to Pseudomonas aeruginosa by decreasing fibre-like substance in biofilms and destroying the structure of biofilms .

目的研究加替沙星热敏凝胶滴眼液（GTGE）对感染兔眼的药效学。

Objective To study the pharmacodynamic effect of gatifloxacin thermosensitive gel eyedrop ( GTGE ) on the rabbits eye of bacterial infections .

方法将115例尿路感染患者随机分为2组治疗组60例，口服加替沙星片0.4g，1次/d；

Methods One hundred and fifteen patients with urinary system infection were randomized into two groups : treatment group ( 60 cases ) took gatifloxacin tabs 0.4 g , once a day ;