受体超家族

GCNF（GermCellNuclearFactor）属于核受体超家族成员，是一个孤儿受体。

GCNF ( Germ Cell Nuclear Factor ) is a member of nuclear receptor superfamily and also an orphan receptor .

RANK是肿瘤坏死因子受体超家族成员，参与组成多条信号传导通路，调节破骨细胞等的增殖分化。

RANK , a member of the tumor necrosis factor receptor superfamily , is involved in several signal transduction pathways and regulates the proliferation and differentiation of osteoclasts .

ERβ属于核受体超家族成员。

ER β is a member of the nuclear receptor super family .

TNF受体超家族成员包括Fas是其中重要的介导分子。

Members of TNF receptor superfamily including Fas are involved in the regulation of activation-induced cell death .

Fas/CD95作为肿瘤坏死因子（TNF）/神经生长因子（NGF）分子受体超家族成员，在细胞凋亡及体内免疫调节方面发挥重要的作用。

As a member of the tumor necrosis factor ( TNF ) / nerve growth factor ( NGF ) receptor superfamily , Fas ( CD95 ) plays an important role in apoptosis and immunoregulation .

其中RXR属于核激素受体超家族，它包括α、β和γ三种亚型，它们可以作为配体激活型转录因子调控多细胞动物生命的许多方面。

RXR belongs to super family of nuclear hormone receptor , which contains three subtypes (α,β and γ), and regulates many aspects of metazoan life as ligand activated transcriptional factor .

DcR3是一个新发现的具有免疫抑制作用的分子，属于肿瘤坏死因子受体超家族的成员。

Decoy receptor 3 ( DcR3 ) is an immunosuppressive molecule which was found recently , belongs to the tumor necrosis factor receptor ( TNFR ) family .

Fas（CD95／APO-1）是TNF受体超家族的重要成员，它通过与其配体FasL相互作用，激活一系列细胞内激酶，将死亡信号传导至细胞内，从而调控细胞的生存和凋亡。

Fas receptor ( CD95 / Apo - 1 ) is one of the most important members in the TNF receptor superfamily . The interaction of Fas and its ligand ( FasL ) results in transduction of a cytolytic signal into the cell , regulating cell survival and death .

近年来，肿瘤坏死因子受体超家族成员-OX40（CD134），作为一共刺激分子对于维持CD4+T细胞的活化、增值、存活起到关键性作用。

In recent years , tumor necrosis factor receptor ( TNFR ) family member-OX40 ( CD134 ), as a key co-stimulatory molecule , involved in maintenance of activation , proliferation , survival of CD4 + T cells .

细胞因子受体超家族与信号转导

Cytokine Receptor Superfamily and Its Role in Signal Transduction

核受体超家族及其辅调节子的研究进展

Progress in nuclear receptor superfamily and nuclear receptor regulator

肿瘤坏死因子受体超家族成员死亡受体在病毒感染中的作用

Roles of death receptors in virus infection

细胞因子受体超家族及其介导信号转导的新途径已引起人们的广泛注意。

The cytokine receptor superfamily and its role in mediating new pathways of signal transduction become more attractive than ever .

雌激素作用的典型机制涉及与属于甾体类受体超家族成员的一系列胞内受体的相互作用和基因的转录调控。

The classical mechanism of estrogen action involves interactions with intracellular receptors , members of the superfamily of steroid receptors , and regulation of gene transcription .

核受体超家族属于反式作用因子，是一类配体依赖性转录因子，其成员广泛介导了真核生物与生长、发育和内环境稳定相关基因的表达。

The nuclear receptor superfamily is composed of a large number of ligand-dependent transcriptional factors that mediate expression of genes associated with eukaryotic growth , development , and homeostasis .

它们是NGF受体／TNF超家族的成员，是凋亡过程中重要的介子。

They are important mediators in the apoptotic process .

维生素D受体是类固醇激素受体超家族的成员，与骨化三醇结合后能调节血钙和骨矿化。

Vitamin D receptor belongs to steroid-hormone receptor superfamily , and binds with calcitriol to regulate blood calcium and mineralization of bone .

死亡途径中大多数死亡受体属于肿瘤坏死因子受体超家族。

Most of death receptors in this pathway belong to the tumour necrosis factor receptor superfamily .

蛋白偶联受体是体内最大的受体超家族，它们参与调节生物体内多种生理功能与病理过程。

G protein-coupled receptors ( GPCRs ) which constitute the largest superfamily of receptors in human genome , regulate a variety of physiological functions and pathological processes .

黑素皮质素受体是G蛋白耦联受体超家族成员。

The melanocortin receptors are members of the super-family of G-protein coupled receptors .

甲状腺激素受体（TRs）属于核受体超家族，由TRα和TRβ基因编码。

Thyroid hormone receptors ( TRs ) belong to the nuclear hormone receptor superfamily . TRs are coded by two separate genes , TR α and TR β .

雌激素受体β（ERβ）属于核受体超家族成员，是一类配体调节的转录因子。

Estrogen receptor β( ER β) is a ligand-regulated transcriptional factor , which belongs to the nuclear receptor superfamily .

孕酮受体（progesteronereceptorPR）基因是核受体超家族成员之一，在介导与调节卵巢排卵、胚胎植入、乳腺发育等生殖生理以及相关生殖健康中起着关键的作用。

Progesterone receptor ( PR ) is a member of nucleolus-receptor superfamily . PR exert important roles for ovulation , embryo implantation , mammary gland development : and other reproductive process .

雌激素相关受体（estrogen-relatedreceptor，ERR）属于核受体超家族，是第一个发现的孤儿核受体，包括ERRα，ERRβ和ERRγ。

The estrogen-related receptor ERR , belonging to the nuclear receptor superfamily , is the first orphan nuclear receptor to be identified . ERR comprise ERR α, ERR β and ERR γ .

生长激素受体（GHR）是I型细胞因子受体超家族成员之一，它与配体生长激素（GH）结合发挥多种生理功能。

Growth hormone receptor ( GHR ) is a single membrane-spanning receptor , and belongs to the class I cytokine receptor superfamily . It binds to the growth hormone ( GH ) to initiate biological actions .

诱骗受体3（DcR3）是肿瘤坏死因子受体（TNFR）超家族的新成员，是一种特殊的细胞凋亡抑制剂，具有抗凋亡特性。

A new member of the tumor necrosis factor receptor ( TNFR ) superfamily , Decoy receptor 3 ( DcR3 ), can reject the apoptosis as a special inhibitor of apoptosis .

极低密度脂蛋白受体（VLDLR）属于低密度脂蛋白受体（LDLR）超家族，结构上由五个结构域组成。

The very low density lipoprotein receptor ( VLDLR ) is a member of the low density lipoprotein receptor ( LDLR ) superfamily . It is composed of five section sharing structural homology with LDL .

G蛋白偶联受体（GPCR）是另一类重要的细胞膜表面受体超家族。

G protein-coupled receptors ( GPCRs ) constitute another superfamily of plasma membrane receptors .

受体酪氨酸激酶是一个具有内在酪氨酸蛋白激酶活性的膜受体超家族，成员众多，信号转导通路复杂多样。

Receptor tyrosine kinase ( RTK ), a membrane receptor superfamily with intrinsic protein tyrosine kinase activity , has many members and complicated signal transduction pathways .

Toll样受体（Toll-Likereceptors，TLRs）是天然免疫中重要的模式识别受体超家族，在机体抗病原体感染中发挥重要的作用，同时也是连接天然免疫与获得性免疫的桥梁。

Toll-like receptors ( TLRs ), a superfamily of pattern-recognition receptors ( PRRs ) play a pivotal role in host innate immunity against pathogen infection and bridge the innate and adaptive immune .