口服给药

  • 网络Oral administration;Oral ingestion
口服给药口服给药
  1. 蛋白类药物口服给药易受胃肠道pH值、酶系统及肝脏首过效应等影响导致生物利用度低,临床一般只能注射给药。

    The oral administration of protein drugs is easily affected by GI pH value , enzyme system , and first-pass effect , as a result of fraction of bioavailability . Protein drugs are commonly given by injection in clinic .

  2. 口服给药1h后,采用BL-410生物机能实验软件系统观察记录大鼠胃的运动状态。

    One hour after oral administration the gastric motion was observed with BL 410 biological function system ( BFS ) .

  3. B组:口服给药组,每天WO-15mg灌胃至处死;

    In Group B , the rabbits were given WO-1 5 mg each day by the oral administration .

  4. 目的研究pH敏感水凝胶的性质及其用于胰岛素口服给药的降血糖作用。

    Objective To study the properties and the application as an insulin delivery vehicle of a pH sensitive hydrogel .

  5. 目前,SOD在临床应用上主要以注射方式给药,而口服给药方式研究较少。

    Nowadays , SOD is used mainly as injection clinically , while oral formulation for SOD is less investigated .

  6. 结论使用PLANP作INS口服给药的载体具有可行性。

    CONCLUSION Oral INS PLA NP was feasible .

  7. 本文采用HPLC法,比较小鼠阴道给药后达那唑血浆浓度及子宫组织内分布与口服给药的差异。

    The concentrations in plasma and uterus of Danazol in mice administrated vaginally or orally have been compared by HPLC methods .

  8. 在口服给药组、肌肉注射组和对照组处理中,以20mg/kg肌肉注射试验组的疗效最佳。

    The group which was administered 20mg / Kg by intramuscular injection was optimum in the test .

  9. 口服给药4个小时后,抑制肽的降压效果明显好于卡托普利(P0.01)。

    After 4 h of administration , the ACE inhibitory peptide showed more powerfully antihypertensive effect than captopril ( P 0.01 ) .

  10. GAL在小鼠的血浆和脑组织的药动过程基本相似。口服给药后,脑内GAL浓度约为血浆的2.62倍。

    The concentration of GAL in brain was 2.62 - fold compared with in plasma after oral administration .

  11. LHRH固体脂质纳米粒口服给药系统的研究

    Study on LHRH-loaded solid lipid nanoparticles for oral administration

  12. 本课题为进一步研制LMWH口服给药系统奠定了理论基础和实验依据。

    The study provided the theoretical foundation and experiment evidence for preparing oral drug delivery system of LMWH .

  13. 结论PLGANPs可能成为大分子蛋白质药物口服给药的新型载体。

    CONCLUSION PLGA NPs might be used as a new oral carrier for protein drug delivery systems in the future .

  14. 多剂量口服给药后辅酶Q(10)缓释片和普通片在健康人体内的血药浓度

    Determination of total coenzyme Q_ ( 10 ) in plasma following dose oral administration of 50 mg coenzyme Q_ ( 10 ) sustained release tablets and regular tablets in healthy volunteers

  15. 多肽、蛋白质类药物的口服给药途径因生物利用度低而受到限制,原因在于这类药物易受胃肠道内pH环境和蛋白酶的影响而失活。

    Oral route of peptide or protein drugs is restricted due to its low bioavailability . The main reason is that such drugs are susceptible to the pH environment in the gastrointestinal tract and protease inactivation .

  16. 综述壳聚糖在生物大分子口服给药、pH敏感释药、靶向给药、纳米药物载体等药物制剂方面的应用研究进展。

    Research advances in pharmaceutical preparations of chitosan were reviewed in this paper , including peroral macromolecular drugs delivery system , pH-sensitive drug release system , targeting drug delivery system , nano-drug carriers , and so on .

  17. 对所制得的化合物用小鼠进行了抗炎镇痛活性试验,发现以200mg/kg剂量口服给药,多数化合物具有明显的抗炎镇痛作用。

    Pharmacological studies showed that , with the dose of 200mg / kg , most of the compounds have potent anti-inflammatory and analgesic activities on mice .

  18. 大鼠口服给药(10mg·kg-1)后,测定不同时间点下HSR903的血药浓度。

    After oral administration of HSR 90 3 ( 10 mg · kg - 1 ) to rats , their concentrations in plasma were measured .

  19. 目的比较四氢叶酸(LV)注射与口服给药解救大剂量甲氨蝶呤(HD-MTX)毒性的效果,了解口服解救安全性。

    Objective To compare the rescue effect of leucovorin taking orally with that of via intramuscular in high-dose methotrexate ( HD-MTX ) chemotherapy .

  20. 方法健康志愿者16名,随机交叉口服给药60mg。

    Methods Sixteen healthy volunteers were given the medicine 60 mg in oral by an open randomized crossover design .

  21. 进行两种制剂一次口服给药300mg的药物动力学和生物利用度比较试验。

    Pharmacokinetics and comparative bioavailability studies were conducted on the subjects after oral administration of naproxen sodium tablets at single dose of 300 mg .

  22. 结论:MST直肠给药具有良好镇痛效果,尤其适合于不能口服给药的晚期癌症患者。

    Conclusion : Rectal administration of MST has remarkable efficacy in cancer pain relief , especially for those cancer of late stage patients to whom oral administration is not available .

  23. 用SD大鼠研究了赛特铂配合物药物材料口服给药的长期毒性,结果表明基本无毒剂量为10mg/kg,20mg/kg是低中毒剂量。

    Researches have been done on the long-term toxicity of oral administration of Satraplatin by using the SD rats , and the results showed that the innocuity dose is 10mg / kg , and 20mg / kg is the low-grade toxicity dose .

  24. 口服给药1h后,肝脏中的放射物浓度为277.5±17.8ng/g,肾脏为182.4±12.0ng/g;

    After oral administration the radioactivity in liver at 1 hour was 277.5 ± 17.8ng/g and that in Kidney was 182.4 ± 12.0ng/g .

  25. 结果:口服给药后,0~6h内,Rhein在血浆中均有分布,给药后0.5h达到峰值。

    The results showed that the level of rhein distributed in plasma reached the max value 0.5 h after the oral administration , and maintained a relatively high value from 0.25 h to 1.5 h.

  26. 西替利嗪0.056~0.50mg·kg-1口服给药时,能明显减轻豚鼠静脉注射组胺所致休克反应的严重程度,并可显著延长豚鼠休克反应的潜伏期及降低死亡率。

    The guinea-pigs were effectively decreased reaction extent of shock and prolonged latency period of shock by orally administered cetirizine ranged from 0.056 to 0.50 mg · kg - 1 , reduced the rate of histamine induced death .

  27. 我们导出了口服给药的平均滞留时间MRTpo和平均吸收时间MAT的计算公式,并利用文献报道的血药浓度数据,验证了这些公式的正确性。

    We have derived the formulae to calculate mean resident time ( MRTpo ) and mean absorption time ( MAT ) after oral administration of drugs , and examined them with literature data .

  28. 奥美拉唑胶囊口服给药40mg后,经方差分析显示2种胶囊的主要药动学参数差异无显著意义(P>0.05)。

    Following per oral administration of omeprazole 40 mg , there were no statistical significant differences of the main pharmacokinetic parameters between the two capsules preparations by the analysis of variance ( P > 0.05 ) .

  29. 目的:探讨中药生物碱口服给药逆转化疗诱导的肿瘤细胞MDR的分子生物学基础,以指导临床应用中药逆转肿瘤多药耐药,提高化疗疗效。

    Objective : To observe the base of the interference in correlated biotic active matter obtained multi-drug resistance induced by chemotherapy for different alkaloid , and to supervise the use in clinic to restrain the multi-drug resistant of chemotherapy , and thereby to improve the curative effect .

  30. 多方面研究表明,I3C是通过这些酸性反应产物在体内发挥作用的,因I3C口服给药后具活性,而通过腹腔注射则无活性。

    Many studies have shown , I3C has the action in the body through these acid reaction products.I3C has activity through oral medication , but it hasnt activity through intraperitoneal .