可乐定

可乐定和汉防己碱抑制高血压大鼠动脉平滑肌DNA合成速率

Inhibition of aortic DNA synthesis by clonidine and tetrandrine in renal hypertensive rats

可乐定对CO2气腹时应激的影响

The effects of clonidine on the stress response of CO _ 2 pneumoperitoneum

HPLC测定复方盐酸多塞平胶囊中盐酸多塞平与盐酸可乐定的含量

Determination of Doxepin Hydrochloride and Clonidine Hydrochloride in Compound Doxepin Hydrochloride Capsules by HPLC

阿普可乐定防止Nd∶YAG激光虹膜切除术后眼压升高

Apraclonidine prevents the acute increase of intraocular pressure in brown eyes with Nd ∶ YAG laser iridectomy

可乐定对小鼠缺血脑皮质前列腺素F（2α）含量的影响

The effect of clonidine on the pgf_ ( 2 α) levels in the brain cortex of mice subjected to cerebral ischemia

而α2受体激动剂可乐定和赛拉嗪以及DA受体激动剂阿朴吗啡，拮抗剂氟哌啶醇均不影响Bus的增强作用。

No effects were found with α 2-adrenoceptor agonists clonidine and xylazine or dopamine receptor agonist apomorphine and antagonist haloperidol in this study .

每天小鼠ip马钱子碱12mg/kg和可乐定100μs/kg，连续给药8天，镇痛作用不产生耐受性。

Daily ip brucine 12mg / kg and clonidine 100 μ g / kg × 8d in mice did not in - duce tolerance in terms of analgesic action .

目的：用薄层色谱法（TLC法）和高效液相色谱法（HPLC法）对可乐定透皮贴剂中有关物质进行检测。

Objective : The methods of TLC and HPLC had been developed to determine the related substances in the clonidine transdermal patchs .

鞘内注射可乐定对福尔马林致痛大鼠脊髓c-fos表达的影响

Effect of Intrathecal Clonidine on C-fos Expression in Dorsal Horn of Spinal Cord in Formalin Inducing Rats Pain

通过电化学聚合，在铂丝表面修饰一层具有导电性能的聚苯胺薄膜，外层涂PVC膜（含四苯硼酸-可乐定活性物质）。

Polymeric films is reported . Platinum wire is modified by conductive polyaniline and then with a film of PVC ( containing electroactive species ) .

目的验证可乐定的抗溃疡性结肠炎（UC）作用，并为UC患者提供一味良好的治疗药物；

Objective To verify the anti-UC effect of Clonidine and provide the patients with UC with a good medicine .

可乐定组注药后SEP振幅显著抑制和潜伏期明显延长，以20～40分钟达高峰，与疼痛相关性最强的N15-P25峰-峰振幅的镇痛率达80.6%。

The peak Pain relief ratio was 80 . 6 % at 20-40 min after clonidine administration .

目的探讨可乐定对严重体表烫伤大鼠心肌抑制性G蛋白α亚基（Giα）表达的作用及机制。

Objective To investigate the effects of clonidine on the expression of myocardial α subunit of inhibitory G protein ( Gi α) in severely scalded rats and the mechanisms .

结果：纳洛酮可易化杏仁核点燃，可乐定、东莨菪碱、MK-801和尼卡地平则可抑制杏仁核点燃发作（P0·05）。

Results : Naloxone facilitated , while clonidine , scopolamine , MK-801 and nicardipine inhibited amygdala kindling ( P0.05 ) .

育亨宾（0.5～5mg/kg，sc）剂量依赖式地拮抗可乐定对小鼠胃肠推进运动及排便的抑制作用。

Yohimbine ( 0.5 ~ 5 mg / kg , sc ) exhibited an antagonistic action on the inhibitory effect of clonidine on the gastrointestinal propulsion and defecation in mice .

除K组于麻醉前60min加服可乐定5μg/kg外，两组患者其他麻醉前用药和诱导插管方法相同。

Oral premedication with clonidine 5 μ g / kg was taken in clonidine group 60 min before anesthesia induction in addition to common anesthesia in two groups ;

目的探讨可乐定（Clo）对福尔马林致痛大鼠的行为学影响机制。

Objective To assess the effect of Clonidine on SD rat 's behavior response and spinal nitric oxide in the formalin test .

结果：在吗啡依赖性猴自然戒断治疗模型上，十复生胶囊2个剂量组（0.5,0.2g/kg）的戒断症状分值明显低于NS组（P<0.05），与可乐定的疗效相当；

Results : Shifusheng capsule at the dose of 0.5g/kg and 0.2g/kg can significantly reduce the withdrawal symptoms in monkeys ( P < 0.05 ) with an effect similar to that of clonidine .

腰2～3椎间隙穿刺、置管，可乐定注射15min后以0.5%左旋布比卡因行硬膜外阻滞。

All epidural anesthesia were performed at the L2-3 interspaces with 0.5 % levobupivacaine after epidural single shot clonidine .

icv可乐定（12μg/kg）抑制大鼠胃肠推进运动作用强于sc同剂量的可乐定。

Clonidine ( 12 μ g / kg , icv ) was found to be more active in inhibiting the gastrointestinal propulsive motility than the same dose of the drug given sc.

在培养开始或培养24小时后加入可乐定（10~（-8）～10~（-5）M），对ConA或PHA诱导的淋巴细胞转化均无明显影响。

Added at the onset of the culture or 24h later , clonidine ( 10 - (?) - 10-8 M ) did not suppress T lymphocyte transformation induced by ConA or PHA .

本实验在新鲜分离大鼠背根神经节（DRG）细胞上应用全细胞膜片箝记录研究肾上腺素α2-受体激动剂可乐定（clonidine）对CABA-激活电流的调制作用。

Whole-cell patch-clamp recordings were performed on neurons from freshly isolated rat dorsal root ganglion ( DRG ) to investigate modulatory effects of clonidine , an α 2 adrenoceptor agonist , on GABA-activated currents .

方法：观察纳洛酮、可乐定、东莨菪碱、MK-801和尼卡地平对杏仁核点燃大鼠的影响，并测定点燃大鼠伏隔核（NAc）脑区的DA及其代谢产物的含量。

Methods : The effects of naloxone , clonidine , scopolamine , MK-801 and nicardipine on amygdala kindling model were observed , and the content of dopamine ( DA ) and its metabolites were determined in NAc in kindled rats .

可乐定（15～120μg/kg，sc）剂量依赖式地抑制小鼠及大鼠胃肠推进运动及小鼠排便反射，此作用明显强于吗啡。

Clonidine ( 15 ~ 120 μ g / kg , sc ) showed a dose related inhibitory effect on the gastrointestinal propulsive motility in mice and rats , and on the defecation in mice . This action of clonidine was much stronger than that of morphine .

可乐定和三七皂苷对30%TBSA烫伤所致大鼠心肌和肺组织Gi2α-、Gi3α-mRNA表达增加具有抑制作用。

Clonidine and PNS significantly inhibited the expression of Gi2 α - mRNA and Gi3 α - mRNA after severe scald in rats .

目的：探讨可乐定生长激素刺激试验（CGHST）在鉴别多系统萎缩（MSA）和原发性帕金森病（IPD）的应用价值。

Aim : To evaluate the applied value of clonidine growth hormone stimulation test ( CGHST ) to differentiate multiple system atrophy ( MSA ) from idiopathic Parkinson 's disease ( IPD ) .

多次小剂量双甲脒染毒（7mg／kg，连续10日）对大脑皮层3H－可乐定结合的抑制程度小于一次大剂量双甲脒的抑制效应。

Repeated dose of amitraz ( 7mg / kg per day for 10 days ) also decreased 3H clonidine binding in cerebral cortex , but the inhibition was less potent than that of above dose of amitraz ( 70 mg / kg ) .

目的探讨体外循环（CPB）期间前列环素（PGI2）、血栓素（TXA2）含量及其比值与糖酵解产物血乳酸含量之间的相关关系及可乐定对其的影响。

OBJECTIVE To study the correlation between carbohydrate metabolism and concentration of prostaglandin I 2 ( PG 2 ) and the thromboxane A 2 ( TXA 2 ) during cardiopulmonary bypass ( CPB ) and the influence of oral clonidine premedication .

而抑制烫伤后心室肌及肺组织的Gi2α和Gi3α基因的转录可能是可乐定、三七皂苷降低烧伤后Giα表达及其抗烧伤后心、肺功能障碍的重要因素。

The inhibitory effects of Clonidine and PNS on the Gi2 α and Gi3 α gene transcription was one of the important mechanisms of the reduction of Gi α expression , which subsequently lead to the alleviation of cardiac and pulmonary dysfunction after scald .

可乐定对小鼠和猫实验性脑缺血的保护作用

Protective effects of clonidine on cerebral ischemia in mice and cats