喹诺酮

7-[（2S）-2-氨甲基-1-吡咯烷基]-喹诺酮衍生物的合成及体外抗菌活性

Synthesis and in vitro antibacterial activity of 7 - [ ( 2s ) - 2-amino methyl-pyrrolidine-1-yl ] - quinolone derivatives

质粒介导的喹诺酮耐药qnr基因的检测

Detection of the qnr gene responsible for plasmid-mediated quinolone resistance

5种喹诺酮抗菌药对金葡菌DNA螺旋酶的抑制作用

Inhibitory effect of 5 quinolones on DNA gyrase from Staphylococcus aureus

氟代喹诺酮和大环内酯抗菌剂都与QT间期的延长有关。

Fluoroquinolones and macrolide antimicrobial agents have both been associated with prolongation of the QT interval .

再利用活化酯法将五种喹诺酮药物直接与BSA和OVA偶联。

Besides five QNs were directly coupled to BSA and OVA by active ester method .

药物中间体生产的GMP管理喹诺酮药物与生物大分子的相互作用

GMP for Manufacturing Pharmaceutical Intermediates in Chemical Works Study of the Interaction between Quinolones and Bio-macromolecules

最低杀菌浓度（MBC）用肉汤稀释法，并用杀菌曲线方法比较两种喹诺酮药物杀菌性能。

The bactericidal activity of levofloxacin was tested using minimal bactericidal concentration ( MBC ) and killing curve methods .

用光谱技术开展了牛血清白蛋白（BSA）与几种喹诺酮药物的相互作用机制研究。

In the first part , the binding characteristics and mechanism of quinolone antibiotics to the bovine serum albumin ( BSA ) have been investigated by using fluorescence spectroscopy and absorbance spectra .

7哌嗪8N喹诺酮酸具有[M-68]特征离子，可能是来自三氢重排的结果。

The [ M-68 ] fragment ion probably results from a rearrangement of three hydrogens .

目的研究细胞间信息传递机制之一假单胞菌喹诺酮信号（PQS）在铜绿假单胞菌发病机制中的作用。

Objective To study the unique cell-to-cell communication mechanism of Pseudomonas quinolone signal ( PQS ) in the pathogenesis of Pseudomonas aeruginosa .

福氏志贺菌耐药分析及gyrA、parC基因突变与对喹诺酮耐药的关系

Analysis of drug resistance of Shigella flexneri and study on ralation between mutant in gyrA 、 parC and quinolone resistance

氧氟沙星（Ofloxacin，OFLX）是第三代喹诺酮抗生素代表药物之一，具有广谱、高效、细菌不易耐药、副作用小等特点，在治疗细菌性腹泻方面发挥了重要的作用。

Ofloxacin ( OFLX ) is one of the candidates of fluoroquinolone-antibiotic with a broad antimicrobial spectrum that may have a potential role in the treatment of bacterial diarrhea .

体外活性评价结果表明，C-3位羧基并非是喹诺酮基本结构中产生抗菌、抗肿瘤作用所必需的基团。

The in vitro bioactive assay showed that 3 - carboxy group is not a necessary group for antibacterial activity and antitumor activity of quinolones .

采用反相高效液相色谱/四级杆串联质谱（RP-HPLC/MS/MS）同时测定鸡肉中的5种喹诺酮药物（quinolones，QNs）。

A reversed phase high-performance liquid chromatography-quadrupole rods tandem mass spectrometric ( RP-HPLC / MS / MS ) method was established for simultaneous determination of residues of five quinolones in chicken muscle .

本文通过建立测定生物样品中两种新型喹诺酮衍生物CS-940及KNT-009浓度的高效液相色谱-紫外检测法（HPLC-UV），对两种化合物在动物体内的临床前药代动力学进行了系统的研究。

New HPLC-UV methods for the determination of CS-940 and KNT-009 in biological specimen were developed and successfully used in the preclinical metabolism and pharmacokinetics study of these two new quinolones .

利用柔性原子受体模型（FLARM）方法对一系列的异黄酮和喹诺酮衍生物表皮生长因子受体酪氨酸激酶抑制剂进行了三维定量构效关系研究，得到了合理的构效关系模型。

Three dimensional quantitative structure activity relationships of isoflavone and quinolone derivatives as tyrosine kinase inhibitors were studied using the flexible atom receptor model ( FLARM ) method . Some 3D QSAR models were built with high correlation coefficients .

外输泵抑制剂对喹诺酮抗凝固酶阴性葡萄球菌活性的影响

Efflux pump inhibitor on the activities of quinolones against coagulase-negative staphylococci

其产生可能与喹诺酮耐药决定区的基因突变有关。

The mutation of QRDR is closely associated to the quinolone resistance .

基于分子静电势的喹诺酮5位构效关系研究

Study on the structure-activity relationship of 5-substituted quinolone by molecular electrostatic potential

N-吡啶取代喹诺酮衍生物的合成及抗菌活性

Synthesis and antibacterial activity of N - pyridine quinolone derivative

荧光光谱法研究喹诺酮抗菌素与过氧化氢酶的相互作用

Interaction Between Quinolone Antibacterial Agents and Catalase by Fluorescence Spectroscopy

肠杆菌科细菌质粒介导喹诺酮耐药机制研究

Study on the Mechanisms of Plasmid-mediated Quinolone Resistance in Enterobacteriaceae

中危组有喹诺酮、芳香族抗惊厥药、别嘌呤醇等。

And intermediate risk group including quinolones , aromatic anticonvulsants , and allopurinol .

新型喹诺酮抗菌药&T3811

A New Quinolone Antibacterial & T - 3811

结核分支杆菌耐喹诺酮等四种耐药基因检测的临床应用和评价

The clinical application and evaluation on detecting four drug resistance genes in mycobacterium tuberculosis

4-喹诺酮-2-羧酸衍生物的合成及抗过敏作用

Synthesis and antianaphylactic action of 4-quinolone-2-carboxylic acid derivatives

目的：设计合成有抗菌抗肿瘤活性的喹诺酮药物。

AIM : To design and prepare quinolone compounds with antibacterial and antitumor activities .

喹诺酮药物与生物大分子的相互作用

Study of the Interaction between Quinolones and Bio-macromolecules

质粒介导喹诺酮耐药机制研究

Study of Plasmid - mediated Quinolone Resistance

喹诺酮药物荷移反应的研究

Study on Charge Transfer Reaction of Quinolones