孕烯醇酮

目的建立同时测定SD大鼠血浆中脱氢表雄酮（DHEA）、孕烯醇酮（PREG）和别孕烯醇酮（AP）的高效液相色谱质谱法。

Aim To establish a method for simultaneously determination of dehydroisoandrosterone ( DHEA ), pregnenolone ( PREG ) and allopregnenolone ( AP ) in rat plasma by HPLC / MS.

小鼠惊厥时孕烯醇酮及其硫酸盐对GABAA受体的调制作用

Modulation of gaba_a receptors by pregnenolone and pregnenolone sulfate in mouse brain during convulsion

与消退组相比，重现组大鼠伏隔核中的别孕烯醇酮（allopregnanolone，AP）水平升高75%（P<0.05）；

Compared with extinct group , AP level increased by 75 % ( P < 0.05 ) in nucleus accumbens ;

采用高碘试剂氧化法合成黄体酮的试验结果表明，高碘试剂IBX、DMP和精制DMP均能氧化黄体酮前体孕烯醇酮得到黄体酮，但氧化的选择性和效率相差甚远。

The synthesis of progesterone showed that the precursor of progesterone could been oxidized by hypervalent iodine reagent IBX , DMP and refined DMP , but the selectivity and yield is very different .

孕烯醇酮唾液酸苷对小鼠记忆障碍的改善作用

Effect of pregnenolone sialic glycoside on memory impairment in mice

硫化孕烯醇酮对老年大鼠学习记忆功能的影响

The effects of pregnenolone sulfate on learning and memory in aged rats

结论：孕烯醇酮唾液酸苷有记忆增强作用。

Conclusion : Pregnenolone sialic glycoside has memory enhancing effects .

结论：孕酮和孕烯醇酮硫酸盐可改善记忆损伤。

CONCLUSION : Progesterone and pregnenolone sulfate can ameliorate the memory deficit .

硫化孕烯醇酮是神经甾体家族中含量最丰富、活性最强的一员。

Pregnenolone sulfate is among the most abundant and the most active members of neurosteroids .

目的探讨神经甾体硫化孕烯醇酮对老年大鼠学习和记忆能力的影响。

Objective To investigate the effects of pregnenolone sulfate on learning and memory in aged rats .

硫化孕烯醇酮对前边缘皮层内侧区诱发兴奋性突触传递的作用和机制

The Effect and Mechanism of Pregnenolone Sulfate on Evoked Excitatory Synaptic Transmission in Rat Prelimbic Cortical Neurons

硫化孕烯醇酮是脑内含量最为丰富一种神经甾体。

Pregnenolone sulfate ( PREGS ) is one of the most abundantly produced neurosteroids in the brain .

雌性大鼠血清和海马雌二醇水平及海马孕烯醇酮水平的动态变化

Dynamic Changes of Estradiol and Pregnenolone Levels in Serum and Hippocampus of Female Rats during Different Estrous Cycle

大量的实验表明硫化孕烯醇酮对认知功能具有明显影响，但机制还不清楚。

Plentiful of experiments suggest that pregnenolone sulfate has significant effect on cognition , but the mechanism is not clear now .

孕烯醇酮和孕烯醇酮硫酸盐对小鼠全脑切片摄取~3H-γ-氨基丁酸的影响

Effects of Pregnanolone and Pregnenolone Sulfate on the Uptake of ~ 3H - γ - Aminobutyric Acid in Slices of Mice Brain

以孕烯醇酮醋酸酯为起始原料，经溴仿反应、酯化反应制得3β-羟基-5雄甾烯-17β-羧酸甲酯，总收率69%。

Methyl 3 β - hydroxy-5-androstene-17 β - carboxylate , the key intermediate of finasteride and epristeride , was prepared from pregnenolone acetate by bromoform reaction and esterification with 69 % overall yield .

结果与对照组相比，纳洛酮催促戒断时，吗啡依赖大鼠伏隔核脱氢表雄酮硫酸酯的水平下降（P<0.05），孕烯醇酮（P<0.01）和谷氨酸（P<0.05）水平均升高。

Results Compared with saline group , in nucleus accumbens of morphine withdrawal rats , the level of dehydroepiandrosterone sulfate ( P < 0.05 ) decreased significantly but the levels of pregnenolone ( P < 0.01 ) and glutamate ( P < 0.05 ) increased significantly .

与戒断对照组比较，吗啡戒断大鼠杏仁核中的孕烯醇酮和别孕烯醇酮水平分别升高45%和42%（P<0·05），γ-氨基丁酸水平降低18%（P<0·01）。

Compared with naloxone control , the PREG and AP levels in rat amygdala of morphine withdrawal group increased by 45 % ( P < 0.05 ) and 42 % ( P < 0.05 ) respectively ; the GABA level decreased by 18 % ( P < 0.01 ) .