无反应性
- anergy
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然而,有些T细胞处于未激发状态,事实上他们被称为无反应性,耐受性的过程灭活了。
Howeer , some T cells are not actiated , in fact they are inactivated by a process called anergy or tolerance .
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结论:SEA初次诱导小鼠脾淋巴细胞时,能显著促进T细胞的活化和增殖;经SEA多次刺激(3次)可诱导T细胞的无反应性。
Conclusion : The activation and proliferation of naive T cells could be induced by SEA singly , and the T cells became anergic by repeated SEA induction in vitro .
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T细胞无反应性不受SEA剂量限制,T细胞受抗原刺激不能产生IL-2不是无能状态产生的唯一原因。
The anergic state of T cells was not limited by doses of SEA and there were other causes on anergic state of T cells excepting IL-2 .
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成熟DC可以激活静息T细胞而介导移植排斥;不成熟DC由于共刺激分子表达缺陷,而诱导T细胞的无反应性,导致免疫耐受。
The mature DC can activate naive T cells to intermediate transplantation rejection . Immature DC can induce T cells non-responsiveness to cause the immunological tolerance because of the costimulator molecule expressive defects .
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近来认为,MSCs通过诱导分裂停滞无反应性来对多克隆和特异抗原T细胞反应有明显的免疫抑制作用。
Recently , MSC have been shown to exert a profound immunosuppressive effect on polyclonal as well as antigen-specific T cell responses by inducing a state of division arrest anergy .
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作为体内主要的Ⅰ型干扰素(IFN)分泌细胞,Pre-DC2还具有诱导T细胞无反应性的能力。
As professional type 1 interferon-producing cells , Pre-DC2 have a capacity to induce an anergic state in human T cell lines .
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CD47是T细胞活化的共刺激因子,活化T细胞凋亡过程,诱导T细胞无反应性,加强TCR信号传导的效率;
CD47 induces costimulatory signals on activation of T cell , T cell apoptosis and T cell anergy and enhances the efficiency of TCR signaling ;
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应用B7抗体可以阻断B7分子与CD28/CTLA-4的相互作用,进而阻断共刺激信号的传递,引起抗原特异性的无反应性或反应低下。
It is well reported that application B7 antibody can block the interaction of B7 and CD28 / CTLA-4 and thereby inhibit the transmission of costimulatory signal . These can result in hypo-response or non-response .
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结论HIC呈内毒素无反应性,其表面内毒素相关受体TLR4、CD14和MD2不表达是其耐受内毒素作用的重要分子机制。
Conclusion There was no response of HICs to LPS stimulation , and no expression of TLR4 , CD14 and MD-2 on HICs may be an important molecular mechanism by which they tolerated to lipopolysaccharide .
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脑部无反应性结核病一例报告
Nonreactive tuberculosis in the brain : report of one case
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骨髓输注和抗淋巴细胞球蛋白诱导对同种异体移植肾特异性免疫无反应性的临床研究
Specific unresponsiveness to renal allografts induced by bone marrow transplantation and ALG
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大剂量静脉注射丙种球蛋白无反应性川崎病的临床分析
Clinical analysis of Kawasaki disease patients with non-responsiveness to high-dose gamma-globulin therapy
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免疫毒素的制备及特异性淋巴细胞无反应性的诱导
The preparation of immunotoxin and induce of immune unresponsiveness
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我们采用多变量分析来验证哪些因子与骨密度的无反应性相关。
Multivariable analysis was performed to determine which factors were independently associated with BMD nonresponse .
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幽门螺杆菌致T细胞凋亡:Fas/FasL介导的T细胞无反应性
T cell anergy during Helicobacter pylori infection stems from the apoptosis mediated by Fas / FasL interaction
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本文对无反应性结核病的发病机理、病理变化、临床特点及误诊原因等进行了讨论。
The pathogenesis , pathological changes , clinical features and the reasons sometimes leading to misdiagnoses were discussed .
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如果缺少协同刺激分子的第2信号,将会导致调节性T细胞的无反应性或特异性免疫耐受。
If human body lacks the co-stimulatory action , T cell response does not occur or immunologic tolerance takes place .
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结果:受刺激侧之鼻分泌液中感觉神经胜的含量会依高张性盐溶液之浓度升高而增加,而对侧无反应性增加。
Results : There was in increasing trend of substance P concentration in nasal secretion , correlating to the concentration of hypertonic saline in the stimulated nasal cavity .
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3E1抗体能与囊虫抗原发生沉淀反应,2G6抗体无沉淀反应性。
The McAb 3E_1 formed precipitate with antigen of C. cellulosae inID , whereas McAb 2G_6 did not .
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聚氨酯和苯乙烯-马来酸酐无规共聚物反应性共混研究&Ⅱ共混物力学性能
Study on reaction blending of polyurethane and styrene-maleic anhydride random copolymer ──ⅱ mechanical properties of blends
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间接ELISA法证实此单抗与其他抗原无交叉反应,特异性高。
Indirect ELISA , this monoclonal antibody confirmed that no cross-reactivity with other antigens , the specificity high .
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无症状气道高反应性与血清特异性IgE及血清嗜酸细胞阳离子蛋白的相关性研究
Correlation of asymptomatic bronchial hyperresponsiveness with serum specific IgE and eosinophilic cation protein
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结果表明,(1)在特异性方面,4种检测体系与BTV亲缘关系最近的EHDV-5无交叉反应,特异性好。
The results showed that : ( 1 ) All four detection systems were specificity with no cross-reaction with EHDV-5 .
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清醒无拘束豚鼠气道反应性特点
Characteristics of airway reactivity in conscious and unrestrained guinea pigs
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结论头孢吡肟(马斯平)治疗儿童呼吸道中重度细菌性感染的疗效显著,无不良反应,安全性好。
Conclusion Cefepime ( maxipime ) was efficacious on children with moderate and severe respiratory infection , and it was also safety .
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本实验建立了清醒无拘束豚鼠气道反应性的测定方法,具有简便、稳定、可定量研究的特点。
A simple , stable determining system in the conscious and unrestrained guinea pigs was established that can quantitatively analyse the airway reactivity ( AR ) .