氨基苷类抗生素

耐高浓度氨基苷类抗生素肠球菌的筛选及治疗对策

Screening and control of Aminoglycoside antibiotics - resistant enterococcus

方法：应用缺口连接酶链反应对3个有明确氨基苷类抗生素应用史的耳聋家系（共20例）及56例听力正常个体的线粒体DNA突变进行分析研究。

Method Blood samples were detected from 3 families with aminoglycoside antibiotic induced deafness and 56 persons with normal hearing function by gap ligase chain reaction ( G LCR ) .

结果：有关药物的生物和制剂样品能够得到良好的分离测定。结论：HPLC-IPD法适于氨基苷类抗生素和链霉菌属抗生素治疗药物监测（TDM）的应用。

Results and Conclusion : The HPLC-IPD methods established can be applied to determine aminoglycoside and streptomycete antibiotics in biological samples in Therapeutic Drug Monitoring ( TDM ) .

氨基苷类抗生素致聋家系线粒体基因突变的检测

Detection of mitochondrial gene mutation in aminoglycoside antibiotic induced deafness families