病因推断

遗传易感性对于病因推断的影响

The effect of genetic susceptibility on causal inference

应用1：1条件logistic回归进行单因素和多因素分析，排除混杂因素、逻辑分析和病因推断，寻找可能的危险因素。

Single variable and multivariate conditional logistic regression analysis were used to analyze risk factors . The confounding factors were excluded , and the risk factors were found by using logic analysis .

目的阐述在观察性流行病学研究中如何运用孟德尔随机化方法进行科学合理的病因推断，以控制混杂因素和反向因果关联对结果的影响。

Objective To explain how to use Mendelian randomization for reasonable etiological inferences to avoid confounding and reverse causation often seen in observational epidemiological studies .

结论孟德尔随机化的应用能够增强观察性流行病学中的病因推断，增进对潜在危险因素的认识，同时可能为研究设计和资料分析提供新思路，具有较大的应用前景。

Conclusion Mendelian randomization principle can strengthen inferences in observational epidemiological studies for well understanding the important etiological factors , as well as provide new approaches for study design and data analysis , so it will be of great prospect .

引起病人的溶血性贫血的病因被依次推断为癌症，狼疮和戊型肝炎。

Various reasons for the patient to have hemolytic anemia were considered , including cancer , lupus and hepatitis E.