突触传递过程

结论光学记录膜电位方法可以在神经细胞群的水平上直观观察VN神经电活动的时空二维方式及其兴奋性突触传递过程；

Conclusion The study indicated that the use of optical recording for revealing visually the synaptic transmission of afferent input in VN in brainstem was feasible .

N-乙基-顺丁烯二酰亚胺敏感性融合蛋白（NSF）为一种ATP酶，是突触传递过程中重要的参与蛋白之一，在突触囊泡与突触前膜融合释放神经递质过程中起着重要的作用。

N-ethylmaleimide-sensitive fusion protein ( NSF ), one kind of ATPase , is considered one of the important proteins in the process of synaptic transmission , which also played an important role in the process of membrane fusion between the synaptic vesicles and presynaptic neurotransmitter release .

大量的生理学和药理学证据表明，AMPA受体失敏在快速兴奋性突触传递过程中起着重要的作用，对单个突触的传递效率、神经元的整合功能和突触的可塑性均有影响。

Many lines of physiological and pharmacological evidence show that AMPA receptor desensitization plays an important role in fast excitatory synaptic transmission by affecting transmission efficacy of individual synaptic bouton , integrative functions of neuron , and synapse plasticity .

本研究为探索初级传入突触传递过程提供了一个有效的方法。

Thus , the present research approach an effective approach to study the modulation of primary afferent synaptic transmission .

结论：实验结果提示吗啡对海马神经元的兴奋作用不是由于吗啡直接作用于兴奋性氨基酸&谷氨酸突触传递过程，而是可能由于抑制了抑制性中间神经元，间接产生的兴奋作用。

Conclusion : The results suggest that the exciting effect of morphine on hippocampal neurons are not due to direct influence of morphine on glutamate synapses transmission , but may result from the inhibition on interneurons , that is " disinhibition " way .

在本课题中，我们的主要研究内容包括以下三方面：（l）改进带背根脊髓薄片的制片方法，建立本实验室的可视膜片钳方法来研究脊髓背角初级传入突触的传递过程；

The present research includes three objectives : ( 1 ) To modifying the method of obtaining the spinal cord slice with attached dorsal root , and establish our lab 's visual patch-clamp method to study the synaptic transmission at primary afferent synapse in spinal dorsal horn ;

在先前的研究中，主要采用细胞内记录与盲插膜片钳方法来研究初级传入突触的传递过程，这两种方法在一些方面有其各自的缺点与局限性。

In previous research , intracellular recording and blind patch-clamp methods were used to study the synaptic transmission at primary afferent synapse . Both methods have shortcomings in certain aspects .

这些结果表明外周输入脉冲序列的主要时间结构特征可以跨突触传递，在突触传递神经信息的过程中短簇脉冲更为有效。

These results suggested that the main temporal characters of peripheral input trains can be transmitted across synapses , and that brief-burst firing is more effective during synapse transmission of neural information .

可视膜片钳方法可以准确测量脊髓背角神经元的突触后电流从而研究初级传入突触的传递过程。

The visual patch-clamp method can accurately assess synaptic transmission by measuring postsynaptic currents of the dorsal horn neurons .