纯合子

1996年，Grekova等人首先利用这一技术对一对纯合子双胞胎（一个患病，另外一个未患MS）作了检测。

Used this technique to detect a pair of homozygote twin with MS patients ( one with MS , and another without ) .

结果每个SNP纯合子为单一产物峰，杂合子则为长度不同的两个产物峰。

Results For the same SNP locus , the homozygote showed a single product peak , and the heterozygote showed two product peaks with different length .

血红蛋白ConstantSpring纯合子及其家系调查

A Homozygote for Hemoglobin Constant Spring in Association with its family Study

13/17染色体易位纯合子猪群随机扩增多态性DNA指纹分析

Fingerprinting Analysis on the 13 / 17 Robertsonian Translocation Pig Population by RAPD

结果118例健康献血员中，14例为T／C杂合子，104例为T／T纯合子。

Results Among the 118 individuals , 14 subjects were heterozygous and 104 homozygous for the T / T allele .

表现为该位点某一等位基因的纯合子，PCR产物电泳结果显示1条深带。

The electrophoretic result showed 1 hyperchromatic band .

探讨了群体融合对选择有效性的影响⒚显性完全且选择不利于纯合子aa时，当群体中隐性基因的频率0≤q＜1／3，群体融合导致选择有效性增加；

Effect of population fusion on effectiveness of selection was explored .

目的建立清洁级NeoR转基因小鼠纯合子品系。

Objective To establish clean homozygote Neo r trangenic mouse strain .

目的：通过遗传学育种使外源基因整合位点随机的HBV转基因小鼠成为单一整合位点的纯合子转基因小鼠。

Objective : To obtain the homozygote of HBV transgenic mice with unique integrated site by genetic breeding .

HLAB纯合子血清学分型错误率也明显高于杂合子（P0005）；

Error rate of HLA B serological typing in the homozygotes was also higher than in the heterozygotes ( P0 005 );

rob（13/17）纯合子猪的联会复合体分析

Synaptonemal Complex Analysis of 13 / 17 Robertsonian Translocation in the homozygous Pigs

结果表明：在所有三个品种中均没有检测到隐性纯合子nn；

The results showed as follows : no homozygous recessive genotype nn was detected .

携带维生素D受体基因纯合子bb、aa或tt基因型可能会增加对白癜风的易感性。

The bb , aa or tt genotype will increase the susceptibility of vitiligo .

Kit无义突变致W~（-3Bao）小鼠生殖腺异常及纯合子贫血死亡

Gonadial Abnormality and Homozygous Decease from the Nonsense Mutation of Kit in W ~ ( - 3Bao ) Mouse

结果表明，4例完全性葡萄胎为二倍体，46，XX，为纯合子，雄性来源。

Cases of complete mole were diploid , homozygous , female , androgenetic in origin .

3种等位基因纯合子个体的PCR产物序列分析表明，这3种等位基因分别有12、13和14次CA双核苷酸重复。

The PCR product sequencing results of homozygous animals representing three alleles revealed that those three alleles contained 12,13 and 14 CA dinucleotide repeats respectively .

结果Southern杂交鉴定出F1代转基因小鼠6只，F2代转基因小鼠7只，其中纯合子3只。

Results 6 F1 generation and 7 F2 generation transgenic mice including 3 homozygotes were identified by Southern blot .

决定胫色性状的Id/id基因为伴性遗传，隐性基因id在纯合子时有个逐步表达的过程；

The Id / id allele that determines shank color demonstrates sex-linked inheritance , and the recessive id is expressed gradually in the homozygotes .

汉族II型纯合子频率和DD型纯合子频率非常显著地区别于欧美人群（P<0.01）；

II genotype frequency and DD genotype frequency are noticeably different from that of European and American people ( P < 0.01 );

结果：PCR成功检测出3种基因型；纯合子基因敲除的小鼠未检测到βB2晶体蛋白的表达。

Results : Three genotypes were successfully ( identified ) and expression of β B2 crystallin protein was not detected in gene knockout mice .

携带X+等位基因的胆石病人胆汁胆固醇摩尔百分比和胆固醇饱和指数高于X/纯合子病人，而总脂质降低。

Cholesterol gallstone patients with X + / genotype had higher biliary cholesterol molar per - centage and cholesterol saturation index but lower total lipids as compared with the patients with X / .

一个纯合子样品经过PCR扩增之后得到的是同源双链，G：C和A：T之间单个碱基的变化的纯合突变对片段的解链温度有影响。

A homozygous sample after PCR amplification , contains a homoduplex , G : C and A : T single base changes have an impact in the melting temperature of the fragment .

糖尿病组中肝细胞核因子1β基因的G等位基因携带者的空腹C肽、△I30/△G30均明显低于AA基因型纯合子。

In the type 2 diabetics , fasting C-peptide and △ I30 / △ G30in carriers with G allele were lower than those in AA homozygotes .

结论载脂蛋白E2等位基因，尤其是ε2/2纯合子基因可能是脑白质疏松症的一种遗传易感因子。

Conclusions : Allele Apo E 2 , especially genotype Apo ε 2 / 2 , seemed to be a genetic susceptible factor for leukoaraiosis .

结论：EH患者α-adducin基因460Trp突变纯合子者服用复方缬沙坦后降低收缩压可获得较好的疗效。

Conclusion : Hypertensive patients with the adducin gene homozygous for T allele showed a greater reduction in systolic blood pressure for valsartan / hydrochlorothiazide treatment .

并且，Bcl-xL在纯合子胚胎肝脏中的表达降低可能是定向红系祖细胞存活率下降的主要原因。

The decreased expression of Bcl-xL in mutant fetal liver cells is likely to be a principal cause of their decreased survival .

结果10名D阳性个体均为RHD+/RHD+纯合子、5份弱D样本及12名携带无效等位基因的Rh阴性个体全部为RHD+/RHD-杂合型。

Results All 10 D positive individuals were detected RHD + / RHD + homozygotes while 5 weak D samples and 12 nonfunctional RHD allele carriers are RHD + / RHD - heterozygotes .

将所得到的纯合子小鼠与正常的C57BL6小鼠交配，仔代鼠经PCR鉴定结果全部为阳性。

The offspring of the crossbreeding of the homozygous mice with normal C 57BL / 6 mice were all positive by PCR examination .

经动物传递和免疫组化证实的密码子129甲硫氨酸纯合子Creutzfeldt-Jakob病

Clinical and pathological study of Creutzfeldt Jakob disease with codon 129 Met / Met by animal transmissions and immunohistochemical stain affirmed

用HLA血清学分型法，从上海129个近亲婚配家庭中筛选到HLA-AB纯合子23个（分布于17个家庭）。

Using HLA serotyping technique , 23 HLA-AB homozygous cells were found from 129 first cousin married families in Chinese population in Shanghai .