组合生物合成

组合生物合成技术在药物研发中的应用

Applications of Combinatorial Biosynthesis Technique in New Drug Research and Development

新药发现和发展的新途径：天然产物的组合生物合成研究

The Novel Approach of Drug Discovery and Development : Combinatorial Biosynthesis of Natural Products

组合生物合成研究进展

Research advances in combinatorial biosynthesis

关于加快我国药物创新体系建设的思考新药发现和发展的新途径：天然产物的组合生物合成研究

Thoughts on The New Drug Discovery and Development The Novel Approach of Drug Discovery and Development : Combinatorial Biosynthesis of Natural Products

组合生物合成是在抗生素产生菌的次级代谢产物合成途径中涉及到的一些酶的编码基因之间的互换，从而产生许多新的非天然的天然化合物。

Combinatorial biosynthesis can produce new " unnatural " natural products through exchange of genes encoding the enzymes involved in secondary metabolites biosynthesis pathway in antibiotics producers .

深入的基因功能分析揭示了他们独特的生物合成途径和调节机理，为正在进行的组合生物合成结构改造和代谢工程产量提高奠定了基础。

Extensive analyses of gene functions , their unique biosynthetic pathways and regulatory mechanisms have now paved the way for more rational structural modifications through combinatorial biosynthesis and yield improvements using metabolic engineering .

阿维拉霉菌是一种什么性质的抗生素，现有的研究成果将有助于采用组合生物合成方法进行阿维拉霉素的分子改造与修饰，从而产生新的阿维拉霉素衍生物。

Avilamycin quality have what kind of quality , the existing returns will help to alter or decorate it 's molecule by the Combinatorial biosynthesis method , and produce new ramification of Avilamycin .

就这2个领域中对红霉素生物合成的研究历史、研究现状和研究前景（组合生物合成）作以简要的介绍。

The history of research studies on these two fields , the current research situation , and the prospect of the research ( combinatorial biosynthesis ) in erythromycin biosynthesis were summarized in this paper .

聚酮化合物的组合生物合成是当前国际化学与生物学交叉学科研究的热点之一，也正在发展成为药物创新超常规的重要手段。

Polyketide compounds and their biosynthesis by combinatorial approaches had received great attention as a cross-disciplinary subject in a new filed of chemical biology for its importance and great potential to create brand new drug in future .

抗生素的广泛应用导致许多病原菌产生严重的耐药性，而新型抗生素的不断筛选及其生物合成机制的不断揭示，能够为组合生物合成和代谢途径工程策略的实施提供丰富的物质资源和信息资源。

The widespread use of antibiotics lead to serious drug resistance for various pathogenic bacteria , whereas the screening of new kinds of antibiotics and discovery of their biosynthetic mechanisms provide abundant material and information resources for implementing combinatorial biosynthesis and metabolic pathway engineering strategies .

本文介绍力达霉素的分子结构与生物合成、化学合成、分子作用机制与抗肿瘤活性、单克隆抗体高效偶联物、组合生物合成等方面研究的最新进展。

This article ( reviews ) the recent research progress of lidamycin , focusing on its molecular structure , biosynthesis , molecular mechanism of action , antitumor effects , conjugation with monoclonal antibody , as well as the prospective of combinatorial biosynthesis of this class of antibiotics .