药物蓄积

结论LR可能通过影响药物蓄积和细胞凋亡参与对胃癌细胞MDR的调节。

Conclusion LR might take part in mediation of MDR in gastric cancer cells through interfering with drug accumulation and cell apoptosis .

临床治疗剂量不造成体内药物蓄积。

Therewere no drug accumulation at clinical dosage .

结论：长时间、大剂量服用Nse可能导致药物蓄积；

CONCLUSION : Nse leads to toxicity easily in the administration with long term and large dose .

以阿霉素（ADM）为指示剂，通过流式细胞仪检测PKCα与PKCβⅠ的相应抗体对SGC7901/VCR细胞内药物蓄积浓度的影响。

The effects of antiPKC α or βⅰ antibody on adriamycin accumulation in SGC7901 / VCR cells were determined by flow cytometric analysis .

试验结果表明：黄连提取物处理后，试验组菌体内诺氟沙星蓄积浓度明显高于空白组（P0.01），说明黄连具有促进菌体内药物蓄积的作用。

The result indicated that the accumulated concentration of medicine norfloxacin within the experiment strains which treated with coptis extract was clear high than blank space ( P < 0.01 ) .

血浆和脾中的药物蓄积量也得到不同程度的增加。

In addition , the accumulation in plasma and spleen were also increased in different levels .

方法菌体内药物蓄积量和主动外排的作用采用荧光测定法；

Methods Fluoroquinolone accumulation in bacteria and the effect of active efflux were measured by a fluorescence method .

硬膜外持续输注低浓度罗呱卡因和麻醉性镇痛药芬太尼无药物蓄积现象，产妇和新生儿均无延迟并发症发生。

Epidural infusion low concentration ropivacaine and fentanyl has no late anesthesia effect and side effect to mothers and neonates .

作为排泄器官，肾脏也有较高的药物蓄积，但蓄积量低于淋巴系统。

Kidney as main excretion organ , the accumulation was bigger than that of other tissues , but lower than that of the lymph nodes .

结果大肠杆菌敏感株和多重耐药菌株内的氟喹诺酮类药物蓄积浓度呈能量依赖性降低，以多重耐药株菌内的蓄积浓度下降最明显。

Results The accumulation of ciprofloxacin in sensitive and multi-drug-resistant ( MDR ) organisms decreased with energy dependence , and the decrease in MDR isolate was prominent .

结论：在老年人麻醉中，数量化脑电调控靶控输注异丙酚可使血药浓度稳定，无药物蓄积，血液动力学的稳定，避免术中知晓、术后苏醒延迟，是可行的；

【 Conclussion 】 Anesthesia with target controlled-infusion propofol modulated by AEPI and BIS in the elderly is feasible with the advantages of keeping stable hemodynamics , avoiding prolonged emergence .

结论朊蛋白在胃癌耐药细胞系SGC7901/ADR和SGC7901/VCR中高表达并对胃癌细胞的药物蓄积有影响。

Conclusion PrP was highly expressed in gastric cancer cell lines SGC7901 / ADR and SGC7901 / VCR . Overexpression of PrP had certain effect on drug accumulation in gastric cancer cells .

其可显著延长紫杉醇在大鼠和小鼠体内的血循环时间，增加其在血浆、肾、卵巢&子宫、肺中的分布量，并减少在肝脏中的药物蓄积。

The blood circulation time of paclitaxel in rats and mice was significantly prolonged , and the accumulation of paclitaxel in plasma , kidney , ovary & uterus and lung was increased and the drug accumulation in liver was decreased .

兽药残留是给畜禽等动物使用药物后蓄积在动物细胞、组织和器官内以及可食性产品中的药物或化学物的原形、代谢产物和杂质。

Residues of veterinary drugs consist of primary forms , metabolites and impurities of medicines or chemical materials which accumulate in the zooblasts , tissues , organs and edible products after animals such as livestocks and poultries have been contacted with medicines .

在决定剂量方案时，必须知道药物在体内蓄积的程度。

In determining dosage regimens , it is also necessary to know the extent of drug accumulation .

氯硝西泮重复给药可有效地控制惊厥复发，但也可引起药物在体内的蓄积。

Repeated administration of CZP would avoid this , but might lead to drug accumulation in the body .

但对心脏中的药物分布没有显著性的影响，而肝脏中的药物蓄积量显著降低。

But the drug accumulation was lower than the 9-NC solution in liver with no significant change in heart .