重氮酮

手性铜催化剂催化的α-重氮酮的环化反应

Asymmetric Cyclization of α - Diazoketones Catalyzed by Chiral Copper Catalyst

反应的普适性很好，各种取代的重氮酮，硝基烯烃以及苄胺或者其他的π共轭的伯胺对该反应都有很好的适用性。

This reaction is good in universality , all kinds of substituted diazoketones , nitroalkenes and benzyl amine or π - conjugated primary amine can afford corresponding products .

利用二茂铁重氮酮1a和5个亚胺2进行[2+2]环加成反应，得到了一系列空间上存在顺反异构的β-内酰胺化合物3a-e，产率为50-86%。

Ferrocenyl diazo ketone 1a was reacted with five imines 2 via the [ 2 + 2 ] cycloaddition reaction , giving a series of β - lactam diastereoisomers 3a-e , with yields of 50-86 % .

主要内容如下：1.二茂铁取代重氮酮的反应。

The main works are summarized as below . 1 . The reactions of ferrocenyl diazo ketone .