重氮乙酸乙酯

2-芳基-4-苯基-2,3-二氢-1,5-苯并二氮杂卓与重氮乙酸乙酯反应机理和立体化学的研究

Studies on the Mechanism And Stereochemistry of the Reaction of 2-Phenyl-4-Aryl-2,3-Dihydro-1,5-Benzodiazepine with Ethyl Diazoacetate

采用重氮乙酸乙酯（EDA）与乳酸乙酯在二水杨醛铜（Ⅱ）催化下进行O&H插入反应合成了香料呋喃酮前体化合物α-甲基-缩二乙醇酸二乙酯。

Ethyl diazoacetate ( EDA ) undergoes a facile bis ( salicylaldehydato ) copper (ⅱ) carbenoid mediated O-H insertion reaction with ethyl lactate to afford the title compound . The title compound was used as a synthetic precursor for flavor : 2,5-dimethyl-4-hydroxyl-3 ( 2H ) - furanone .

重氮乙酸乙酯的碳原子既具有亲电性又具有亲核性，而且是一个偶极离子，所以它的反应是多种多样的。

The carbon atom of ethyl diazoacetate is not only electrophilic and nucleophilic , but also is a dipolar ion , so the reaction about it is varied .

重氮乙酸乙酯能够与醇、酚、羧酸、胺等发生烷基化反应，还可以与醛酮反应生成多一个亚甲基的酮。

Alkylation reaction happens when Ethyl diazoacetate reacts with alcohol , phenol , carboxylic acid , amine . Besides , Ethyl diazoacetate can also react with aldehydes or ketones to produce ketones which have one more methylene group .