毒抗

蝎毒抗肿瘤多肽对小鼠肝癌细胞H（22）及移植瘤的抑制作用

Inhibitory effect of antineoplastic polypeptide from Buthus martensii venom on transplanted tumors and H_ ( 22 ) cells : An experimental study

皖南尖吻蝮蛇毒抗凝血因子Ⅱ（ACFⅡ）与活化凝血因子Ⅹ（FⅩa）在钙离子作用下形成了1∶1的复合物，从而延长凝血时间。

Anticoagulation factor ⅱ ( ACF ⅱ) from the venom of Agkistrodon acutus forms a 1 ∶ 1 complex with activated coagulation factor ⅹ ( F ⅹ a ) in the presence of Ca 2 + ions .

目的观察纯化蝎毒抗肿瘤多肽穴APBMV雪，<3500kD灌胃对小鼠肝癌H22动物移植瘤的抑制作用及对H22细胞的体外抑制杀伤作用。

Objective To observe the inhibitory effect of antineoplastic polypeptide from Buthus martensii venom ( APBMV ) on transplanted tumors-hepatoma 22 ( H22 ) and its cells .

蝎毒抗海人酸诱导大鼠癫痫的作用

Antiepileptic effect of scorpion venom on SD rats with Epilepsy induced by kainic acid

尖吻蝮蛇毒抗凝血因子Ⅰ的稀土离子荧光探针研究

Study on Anticoagulation Factor ⅰ from Agkistrodon Acutus Venom by Rare Earth Ion Probes

东亚钳蝎毒抗癫痫肽的作用及其与已知药的作用比较

Effect of AEP obtained from the venom of Buthus martensii Karsch and Its Comparision with other similar drugs

钙（Ⅱ）对尖吻蝮蛇毒抗凝血因子Ⅰ的抗凝血活性的影响

The Effect of Calcium (ⅱ) on the Anticoagulant Activity of Anticoagulation Factor ⅰ from the Venom of Agkistrodon Acutus

近年来国内外有关蝎毒抗肿瘤的研究有不少报道，但其抗肿瘤的机制还不完全清楚。

In recent years , there were some reports about anti-cancer actions of scorpion venom , but the anti-tumor mechanism was poorly understood .

方法按全国鼠类抗药性监测协作组统一方法，对龙门县城区内所捕捉的55只褐家鼠、20只黄胸鼠进行无选择性摄毒抗药性监测。

Methods Fifty-five Rattus norvegicus and 20 Rattus flavipectus were captured in Longmen area and their resistance to rodenticide was monitored based on the procedure recommended by the National Collaborating Group for monitoring resistance of rodent to rodenticide .

口服携带人IL-12、GM-CSF基因的减毒沙门菌抗肿瘤作用的试验以减毒沙门菌作为DNA疫苗载体的研究

Study on the anti-tumor effect of an attenuated live Salmonella containing human IL-12 and GM-CSF genes administrated by oral route

瘀毒清抗B16黑色素瘤血管生成的研究

Study on the Inhibitory Effect of Yu - Du - Qing on tumor angiogenesis in B16 melanoma

因此，本试验研究成果具有较高的价值，为大黄乙醇提取物在动物体内的抗NDV强毒及抗其它病毒的研究打下一定基础。

Therefore the test results has high value and lays a foundation for anti NDV virus and other virus with rhubarb ethanol extract in animal in vivo .

研究背景：羧胺三唑（Carboxyamidotriazole，CAI）是一个主要由美国国家癌症中心研究的非细胞毒类抗肿瘤新药，其抗肿瘤特性、抑制血管生成作用已经得到证实。

Background : Carboxyamidotriazole ( CAI ), a non-cytotoxic anticancer drug , newly developed by National Institute of Cancer ( NCI ) of the United States , has been proven to be tumor-suppressive , anti-angiogenic .

CA-4不仅是一种针对微观蛋白的新式细胞毒类抗肿瘤物质，也是肿瘤血管生成抑制剂，而且对正常的脉管系统没有副作用。

CA-4 has been studied intensively because of its potent anti-cancer activity . CA-4 not only is a new cytotoxic agent ( target in tubulin protein ), but also is a tumor angiogenesis inhibitor and it is relatively inactive in normal tissues .

细胞毒类抗肿瘤新药非临床安全性评价的一般考虑

General consideration for nonclinical safety evaluation of new anticancer drugs

蟾毒内酯抗柯萨奇病毒、腺病毒和流感病毒作用的研究

Study of antiviral activities of Bufogenin on influenza virus , adenoviruses and coxsackievirus

中草药保健香烟的减毒及抗突变作用初步研究减阻添加剂的历史和现状

The Toxicity Attenuation and Antimutagenic Effect of Health-preserving Cigarettes Made From Chinese Herbal Medicine

反义硫代寡核苷酸增强细胞毒药物抗乳腺癌活性的体外研究

A Study of Antisense Oligodeoxynucleotides As A Chemo-Sensitizer to Cytotoxic Agents on Proliferation of Breast Cancer Cell Lines in Vitro

复方藿香洗剂对7种致病真菌抑菌试验和临床应用鉴于稻瘟霉模型具有细胞毒和抗真菌双重筛选作用，我们对以上化合物进行了抗真菌活性的研究。

Anti-fungal Test of Composite Agastache Lotion on Seven Pathogenic Fungi and Its Clinical Application Anti-fungal test showed the compounds above exhibited strong activity .

锌抗石英细胞毒、抗镍煤尘毒作用机制及其在尘肺防治中的应用

Mechanism of Antagonism of Zinc to Poisonous Effect of Quartz Dust and Coal Dust with Nickel on Cell and Its Application in Prevention and Cure of Pneumoconiosis

为了取得最佳治疗效果，临床肿瘤治疗中常将两种或者更多种相互间具有增效减毒的抗肿瘤药物联合应用，即联合化疗。

In order to get the best curative effects , it is common to combine two or more drugs to have a less toxic and a more powerful anti-tumor effect during clinical treatment .

由于传统细胞毒类抗肿瘤药物存在选择性低，毒性大等缺点，目前抗肿瘤药物研究正从传统的细胞毒类药物转移到基于肿瘤发生机制的靶向抗肿瘤药物。

As the traditional cytotoxic anticancer drugs usually have low selectivity , severe toxicity and other side effects , the anticancer drug developments are currently transferring from cytotoxic to targeted agents based on the mechanisms of tumorigenesis .

耐硫变换催化剂发展趋势是：添加新型助剂，提高催化剂的耐低硫，耐毒及抗氧能力，改进催化剂制备方法，降低催化剂生产成本。

The developing trend of sulfidation resistance shift catalyst is adding new catalytic promoter to improve the sulfidation resistance , toxicant resistance and oxidant resistance ; improving the preparation technology of catalyst to reduce the production costs of catalyst .

草甘膦N-乙酰转移酶（GAT）能通过N-乙酰化的作用使草甘膦脱毒，在抗除草剂转基因作物中具有潜在的应用价值。

Glyphosate N-acetyltransferase ( GAT ) is capable of detoxifying glyphosate by N-acetylation , which could potentially be used in herbicide resistence transgenic crops .

蝎毒耐热蛋白抗癫痫作用的实验研究

Study on Antiepileptic Effect of Scorpion Venom Heat - resistant Protein

金丝桃细胞毒作用和抗肿瘤作用研究

Studies of cytotoxic effect and antitumor effect by Hypericum chinense

紫杉醇脂质体细胞毒作用和抗瘤作用的研究

Study on Cytotoxic Effect and Antitumor Effect of Paclitaxel Liposome

新鬼臼毒衍生物的抗肿瘤与抗氧化作用的研究

Antitumor and Antioxidation Effects of the New Podophyllotoxin Derivative

镍煤尘致细胞毒和锌抗细胞毒作用的研究

The study on the cytotoxicity of nickel coal dust and anti cytotoxicity of zinc

结论：七种稀土配合物对六株人肿瘤细胞具有较强的细胞毒活性，抗瘤谱较广；

CONCLUSION : Seven RE complexes exhibit strong cytotoxicity in all human tumor cell lines tested .