消旋体

虽然许多体内外试验结果都表明，S（+）-布洛芬作为优对映体在抑制前列腺素生成上优于R（-）-布洛芬，然而，市售的产品中仍多数为消旋体形式。

Although the S ( + ) - enantiomer of ibuprofen is the eutomer with respect to inhibition of prostaglandin formation , the marketed products containing ibuprofen are almost all supplied as the racemate .

它们都是手性分子，属于外消旋体。

They are all chiral molecules and belong in the racemate .

（R／S）－，（S）－和（R）－PPF对PR，QRS和QTc间期的影响两对映体间及与消旋体间差异均无显著性。

No significant difference was detected for effects on PR , QRS and QTc between ( R / S ) propafenone and the enantiomers .

测定它们对20株临床分离和标准革兰阴性菌和标准革兰阳性菌的最低抑菌浓度。结果表明，5a和5b的体外抗菌活性与外消旋体5c基本相当。

The in vitro antibacterial activities of 5a and 5b against 20 Gram-negative and Gram-positive bacteria were comparable to that of racemic compound 5c .

综述了前列腺素的关键手性中间体&Coreylactone的制备方法，重点阐述了Coreylactone的外消旋体拆分法，不对称合成法及手性源原料法的最新研究进展。

The paper surveys the preparation of chiral Corey lactone , a key intermediate in prostaglandins synthesis , including optical resolution , asymmetric synthesis and chiral pool .

综述了催化氧化偶联2-萘酚合成外消旋体1,1′-联二萘酚（BINOL）的方法。

Synthesis of racemic 1,1 ′ - bi-2,2 ′ - naphthol ( BINOL ) by catalytic oxidative coupling of 2-naphthol was reviewed .

以乙醇水为流动相，用纤维素三（苯甲酰酯）（CTB）作为手性固定相对外消旋体托品酸进行了高效液相色谱手性分离。

Reverse phase chromatography was employed for chiral separation of tropine acid enantiomers on the cellulose tribenzoate ( CTB ) chiral stationary phases coated on a small particle spherical silica support in an eluant system consisting of a mixture of alcohol and water .

含氨基酸的手性化合物外消旋体的制取方法

Method of Preparation in Chiral Compound 's Racemate of Amino Acids

对外消旋体实施拆分是获得手性物质的重要途径。

Raceme resolution is the main route for preparation of chiral compounds .

研究了工业脂肪酶拆分消旋体烯丙酮醇。

Enzymic resolution of allethrone in industrial lipase was studied .

外消旋体拆分是获得单一手性化合物的重要途径。

Raceme separation is the main rout for preparation of pure enantiomers .

结果：合成外消旋体蒜氨酸。

Results : The racemic body alliin is obtained .

一种新型气相色谱手性固定相的制备及其对苄腈外消旋体的拆分

Preparation of a New Chiral GC Stationary Phase and Resolution of Benzyl Cyanide Enantiomers

2-（9-蒽基）-2-羟基乙酸及其衍生物的外消旋体拆分

Resolution of racemic 2 - ( 9-anthranyl ) - 2-hydroxyacetic acid and its derivations

酶法水解在消旋体拆分中的应用

Resolution of Racemate by the Hydrolysis with Enzyme

然后经酸性水解得苯丙氨酸消旋体。

After acidic hydrolysis , phenylalanine was obtained with total yield of 62.5 % .

手性流动相添加法拆分酮康唑外消旋体

Separation of ketoconazole enantiomers using high performance liquid chromatography with chiral mobile phase additives

酶催化外消旋体的动态动力学拆分反应研究进展

Dynamic Kinetic Resolution of Racemes Catalyzed by Enzyme

利用螺旋理论和稳定的交叉式构象，合理地解释了内消旋体消旋的原因。

By use of the helix theory and stable staggered conformation answer can be obtained .

在正相色谱条件下，对15种外消旋体化合物进行拆分，其中11种手性化合物得到了好的分离。

Among the 15 racemates , 11 chiral compounds could be separated on the column .

指出了内消旋体消旋原因传统解释的不合理性。

For the reason why optical activity of mesomer is counteracted classical answer was not convincing .

外消旋体是不旋光的。

The racemate is optically inactive .

当手性药物以外消旋体供药用时，其对映体间就可能发生药效学和药代动力学的相互作用。

Pharmacological interactions between the enantiomers may happen when a chiral drug was used as its racemate .

利用外消旋体进行化学-酶催化动态动力学拆分是制备单一手性化合物的有效手段之一。

The methods of kinetic resolution , dynamic kinetic resolution and enantioconvergence resolution were compared with each other .

在有效剂量相似的情况下，赤式消旋体的安全范围比苏式消旋体高出5～6倍。

The safe range of erythro form racemic was 5-6 times larger than that of threo form racemic .

以有机碱为催化剂，通过三唑三甲基丙酮与2，4-二氯苯甲醛的反应，合成了具有生物活性的外消旋体化合物烯唑醇。

By using alkalamides as the catalyst , diniconazole has been synthesized by the reaction of triazolyl-trimethylacetone and2,4-dichlorobenzaldehyde .

萃取拆分技术适用性强、于连续拆分有望成为外消旋体拆分分离操作的先进技术。

It is hopeful that the extraction separation method will become the advanced technique for the racemates separation .

介绍一个绿色化的外消旋体化合物拆分与光活性表征的微型综合化学实验。

A new comprehensive chemistry experiment study on the optical resolution and the characterization was introduced as microscale laboratory .

还可以少走弯路，加快研发进度。此外，开展手性研究对正确评价外消旋体药物，指导临床合理用药也具有重要的意义。

Furthermore , the research on the chiral drugs has significance of evaluating the racemate drug in clinical application .

脂肪酶催化的外消旋体动力学拆分是不对称催化领域中极具吸引力且发展非常迅速的重要技术。

Lipase-catalyzed kinetic resolution of racemates is considered to be one of the most fascinating topics in asymmetric catalysis .