硫酸乙酰肝素

Glypican-3（GPC3）为膜性硫酸乙酰肝素多糖蛋白，通过糖基磷脂酰肌醇（GPI）结合于细胞表面，是硫酸类肝素糖蛋白聚糖（glypican）家族成员。

Glypican-3 ( GPC3 ) is a heparan sulfate proteoglycan that is bound to the cell membrane by a glycosylphosphatidylinositol ( GPI ) anchor , which is a member of Glypicans family .

人主动脉硫酸乙酰肝素蛋白聚糖对培养的人血管壁细胞生长的作用

Effect of Human Aortic Heparan Sulfate Proteoglycan on the Proliferation of Cultured Cells of Human Vascular Wall

转移性腺样囊性癌细胞纤连蛋白和硫酸乙酰肝素蛋白多糖mRNA的表达

Expression of HSPG and Fibronectin mRNA in Metastatic ACC Cell Line

目的综述硫酸乙酰肝素蛋白聚糖（heparansulfateproteoglycan，HSPG）与血管形成的关系。

Objective To review the relationship between heparan sulfate proteoglycan ( HSPG ) and angiogenesis .

硫酸乙酰肝素在MDA-MB-231细胞增殖抑制中的作用

The inhibitory effect of heparan sulfate on the proliferation of MDA-MB-231 cells

HE染色及免疫组织化学检测主动脉内膜硫酸乙酰肝素蛋白多糖（HSPG）表达。

Heparan sulfate proteoglycan ( HSPG ) expression in intima of aorta was determined by immunohistochemical method .

HSPGs主要由一个蛋白核心和数个与之共价连接的线性硫酸乙酰肝素（HeparanSulfate，HS）侧链组成。

HSPGs are glycoproteins mainly consisting of a protein core and side chains of several linear heparan sulfate ( HS ) covalent linking to the protein core .

背景与目的：乙酰肝素酶（heparanase，Hpa）为降解硫酸乙酰肝素多糖的内糖苷酶，在多种恶性肿瘤的侵袭转移中发挥重要作用。

BACKGROUND & OBJECTIVE : Heparanase , a kind of endo-D-glucuronidase , degrades heparin sulfate proteoglycans , and plays important roles in invasion and metastasis of many kinds of malignant tumors .

目的探讨硫酸乙酰肝素蛋白多糖基因（HSPG）多态性与中国汉族人2型糖尿病肾脏并发症之间的关系。

Objective To explore the association between the heparan sulfate proteoglycan gene ( HSPG ) polymorphism and diabetic nephropathy in Chinese .

目的观察硫酸乙酰肝素蛋白聚糖（HSPG）对C3H小鼠乳腺癌移植瘤的抑制作用及其机制。

Aim To observe the anti-tumor activity and the mechanism of heparan sulfate proteoglycan ( HSPG ) on C3H mice transplanted tumors .

血液持续在血管中流动而不发生血栓的原因在于与血液直接接触的血管内皮细胞表面表达有与Hep类似的抗凝物质&硫酸乙酰肝素（HeparanSulfate，HS）。

The reason for the blood flowing without thrombosis in vesseles is that there is the anticoagulant substances-heparan sulfate ( Heparan Sulfate , HS ) expressed in the surface of vascular endothelial cells contacted with blood directly .

硫酸乙酰肝素-Toll样受体内源性配体与急性胰腺炎硫酸乙酰肝素蛋白多糖（HSPG）mRNA在实验性大鼠腹主动脉瘤组织中的表达及意义

Alterations of Toll Like Receptor 4 and CD14 Expression on Peripheral Blood Monocytes during the Early Stage of Human Acute Pancreatitis Expression of Heparanase Sulfate Proteoglycan mRNA and Its Significance in the Mice Model of Abdominal Aortic Aneurysm

硫酸乙酰肝素（HeparanSulfate，HS）参与乳腺癌发生和发展的多个环节，随着HS对细胞生长因子调节机制研究的深入，HS多糖类似物的研发已经成为当前研究的热点。

Heparan Sulfate ( HS ) is involved in many pathological processes of breast cancer . With the deep insights of the mechanism of growth factors modulated by HS , the research and development of heparan sulfate polysaccharide analogs became the hotspot .

气道阻塞最严重的三个患者同样证实硫酸乙酰肝素抗体A04B08和绑定肝细胞生长因子的干扰作用。

Three patients with the most severe airway obstruction also demonstrated interference of heparan sulphate antibody A04B08 with hepatocyte growth factor binding .

肿瘤侵袭转移必须突破细胞外基质（ECM）和血管内皮下基膜（BM）屏障，硫酸乙酰肝素蛋白多糖（HSPG）是细胞外基质和血管基膜的主要成分。

Tumor invasion and metastasis have to break down the barriers of extra cellular matrix ( ECM ) and blood vessel basement membranes ( BM ) . Heparan sulphate proteoglycans ( HSPGs ) is one of the main components of ECM and BM .

本文检查了转化生长因子β1（TGFβ1）对基础培养下的牛肾上腺皮质细胞硫酸乙酰肝素蛋白多糖（HSPG）合成的调节作用，发现TGFβ1对HSPG的合成具有强大的刺激作用。

In this study , we examined the action of transforming growth factor β 1 ( TGF β 1 ) on the synthesis of bovine adrenocortical cell heparan sulfate proteoglycans ( HSPG ) . It was found that TGF β 1 strongly stimulated the HSPG synthesis .

有趣的是，抗硫酸乙酰肝素抗体HS4C3可以直接抑制表位下调，可以被肝细胞生长因子绑定干扰。

Interestingly , the anti-heparan sulphate antibody HS4C3 , which is directed against a down regulated epitope , interfered with the binding of hepatocyte growth factor .

也有研究认为，TZD与改善硫酸乙酰肝素原多糖（HSPG）合成及硫酸化、从而抑制肾小球基膜（GBM）外疏松层的阴离子位点有关。

Some studies suggested that it may be related to the action of ameliorating the synthesis of heparan sulfate proteoglycans ( HSPG ), and then suppressing the loss of anionic sites of glomerular basement membranes ( GBM ) of diabetic rats .

但DEAE-SephadexA-25柱层析及在0.1MHCL中的电泳分析，均说明患者排泄的硫酸乙酰肝素是不均一的，它至少有两种硫酸基及电荷密度不同的分子类型。

However , the analysis of glycosaminoglycans with DEAE-Sephadex A-25 chromatography and electrophoresis in 0.1 M HCL showed that urine heparin sulfate of the patients arc heterogeneous , and that it covers , at least , two molecular types with different amount of sulfate and charge density .

硫酸乙酰肝素多糖类似物的抗乳腺癌活性研究进展

Development progresses of heparan sulfate polysaccharide analogs with anti-breast cancer activity

硫酸乙酰肝素硫酸酯酶硫锆催化合成1,3-二氯-异丙醇的研究

Study on synthesis of 1,3-dichloro-isopropanol catalyzed by zirconium-loaded sulfuric acid

肝素和硫酸乙酰肝素抑制草酸钙结石形成的化学基础

Chemical Basic of the Inhibition of Calcium Oxalate Stones by Heparin and Heparan Sulfate

内皮细胞硫酸乙酰肝素蛋白聚糖与细胞粘附关系的实验研究

Experimental Study on the Relationship between Heparin Sulfate Proteoglycans of Endothelial Cells and Cell Adhesion

宫颈上皮内瘤样病变和浸润性宫颈癌均可发生细胞表面硫酸乙酰肝素表达缺失

Loss of cell-surface heparan sulfate expression in both cervical intraepithelial neoplasm and invasive cervical cancer

人冠状动脉硫酸乙酰肝素蛋白聚糖的分布和变化与动脉粥样硬化形成的关系

Relationship between distribution and change of heparan sulfate proteoglycan and atherogenesis in human coronary arteries

硫酸乙酰肝素糖蛋白的结构-功能多样性与相关修饰酶群作用

The diversity of structure and function of heparin sulfate proteoglycans via modification of some relative enzymes

硫酸乙酰肝素协同细胞因子对脐血造血细胞体外生长的作用

Synergic effect of heparan sulfate and cytokines on in vitro growth of human umbilical cord blood hematopoietic cells

肝素和硫酸乙酰肝素是由糖醛酸一（1&4）一D一氦基葡萄糖的重复二糖单元组成的线性多糖。

Heparin and heparan sulfate are linear polysaccharides consisting of repeating disaccharide units of uronic acid –( 1 4 ) - D-glucosamine .

这种蛋白多糖表现出明显的不均一性。因为三种分子硫酸乙酰肝素蛋白多糖的分子量分别是230、8.3和330kDa。

These heparan sulfate proteoglycans expressed cl-early the heterogeneity , because their molecular weights are 230 , 8.3 and 330 kDa respectively .

并对经分离纯化得到的猪肝组织硫酸乙酰肝素的二糖组成进行分析，发现与猪内肠组织硫酸乙酰肝素有明显差异，证明了二糖组成分析是比较不同来源糖胺聚糖细微结构差异的良好方法。

The method was then used to analyze the purified porcine liver heparin sulfate which have found has a quite different disaccharides composition to porcine intestine heparin sulfate .