自噬

自噬对维持胰岛B细胞正常功能的作用

The role of autophagy in maintaining pancreatic beta-cell function

电镜、免疫荧光染色、westernblot等方式检测自噬水平的改变。

The change of autophagy was detected by electron microscopy , immunofluorescence , and Western Blot .

自噬又称为二型细胞死亡（typeⅡCellDeath），是细胞程序性死亡的一种，其特征是自噬体的聚集。

Autophagy also known as type II cell death , is a kind of programmed cell death , which is characterized in autophagosome aggregation .

甘氨酸对ATP耗竭诱生性细胞自噬的作用及其机制

Effects of glycine on the ATP depletion-induced autophagy in MDCK cells

自噬强度与GD持续时间呈非线性相关。

Autophagy intensity and duration of a non-linear GD related . 3 .

然而多种应激而产生持续、过度的自噬时，也会导致细胞死亡，称为自噬性细胞死亡（autophagiccelldeath），即Ⅱ型程序性细胞死亡。

However , dysregulated or excessive autophagy could cause autophagic cell death , the type II programmed cell death .

冬凌草甲素通过诱导人宫颈癌HeLa细胞自噬下调凋亡的机制

Mechanism of downregulation of apoptosis by autophagy induced by oridonin in HeLa cells

形态学研究显示PD患者的神经元丢失主要有以下几种形式：凋亡、坏死、自噬。

Morphology study suggests the loss of neurons in PD patient mainly in three forms : apoptosis , sclerosis , autophagy .

自噬/溶酶体途径在NMDA受体介导的神经兴奋性毒性中的作用

Roles of an Autophagy / lysosomal Pathway in Excitotoxicity Mediated by NMDA Receptor

目的：自噬（Autophagy）在肿瘤治疗中发挥重要作用。

Objective : Autophagy plays an important role in cancer therapy .

结论：1.自噬/溶酶体途径参与了TBI后的病理生理过程。

Autophagy / lysosomal pathway involved in the physiopathologic course of post-TBI .

另外，通过MDC染色、免疫荧光和电镜的方法证实了compoundC对CML细胞的自噬诱导作用。

In addition , cell autophagy was induced by Compound C , which detected by MDC staining , immunocytochemistry and electron microscopy .

线粒体△Ψm下降可能是VCR诱导自噬性细胞凋亡的关键环节。

The disruption of the maybe is the key event of VCR-induced autophagic apoptosis .

另外，RD除了引起细胞凋亡，是否诱导其他类型的细胞死亡如自噬性死亡还没有被证实。

In addition , whether RD induce other forms of cell death such as autophagy has not been investigated .

这些结果清楚地显示：在TBI后自噬途径持续地活化。

These results clearly show that the autophagy pathway is persistently activated after TBI .

电镜下观察，TBI之后的神经元内存在明显的自噬小体与自噬溶酶体积聚。

Under EM , both APs and ALs accumulate markedly in neurons after TBI .

此外，自噬和caspase的抑制剂联合用药能够明显减少细胞的死亡率。综上所述，RD在成骨肉瘤细胞中同时诱导细胞凋亡和自噬。

Moreover , RD-induced cell death was significantly restored in combination of autophagy and caspase inhibitors in osteosarcoma cells .

白藜芦醇诱导Raji细胞死亡的自噬途径

Autophagy Pathway of Raji Cell Death Induced by Resveratrol

促进细胞增殖因素（F2）有降低自噬水平的作用，但效果不显著。

Proliferation factor ( F2 ) had inhibitory effect on autophagy , although the effect was not significant .

自噬与凋亡机制在crotoxin诱导的K562和MCF-7细胞死亡中的相互作用

Cross-talk between Autophagy and Apoptosis in Crotoxin-induced Death of K562 and MCF-7 Cells

自噬性细胞死亡是一种不同于凋亡、不依赖于caspase的程序性细胞死亡。

Autophagic cell death is a type of programmed cell death different from apoptosis , caspase - independent .

结果表明：岩藻多糖硫酸酯可以通过诱导Hela（？）田胞发生凋亡以及自噬性程序性细胞死亡，来抑制细胞的生长。

The result revealed that fucoidan effectively inhibits the growth of Hela cells by inducing autophagy , as well as apoptosis .

抗CD3单克隆抗体对人CD4~+CD25~+T淋巴细胞凋亡和自噬的影响

Apoptosis and autophagy induced by anti-CD3 monoclonal antibody in human peripheral blood CD4 ~ + CD25 ~ + T lymphocytes

吖啶橙染色后荧光显微镜下观察细胞酸性自噬泡（AVO）的形成；

Formation of acidic vesicle organelles ( AVO ) was observed by staining with acridine orange under fluorescence microscope .

同时我们发现H1诱导人非小细胞肺癌细胞发生自噬，抑制H1诱导的细胞自噬可以促进H1诱导的细胞凋亡。

Autophagy , induced by H1 , inhibited H1-inducing apoptosis in human non-small cell lung cancer cells .

结论苦参碱体外能诱导BEL-7402细胞自吞噬和自噬性死亡。

Objective To study the effects of matrine on inducing autophagy and autophagic death in BEL-7402 cells .

EGCG抑制自噬的效果呈剂量-效应关系。

EGCG inhibits the growth of cancer cells and inhibits autophagy in a dose response manner . 2 .

决定TBI后的自噬活性是否变化，首先在透射电镜下观察脑切片。

To determine whether autophagic activity is altered after TBI , we first examined brain sections by transmission EM.

TNF-α是否可以通过内质网应激导致B16细胞自噬有待进一步研究。

But whether endoplasmic reticulum stress could trigger autophagy induced by TNF - α need to be elucidated .

EGCG与顺铂联合作用造成大量的自噬小体囤积在宫颈癌细胞内，并造成自噬受阻。

Combination of EGCG and cisplatin caused autophagosome accumulation in cervical cancer cells and cause autophagy blocked . 4 .