分子靶标

环氧化酶（cyclooxygenase，COX）家系被显示与恶性肿瘤的增殖和凋亡耐受有关，COX2可作为恶性肿瘤治疗和预防的重要分子靶标。

Accumulating evidence suggests that cyclooxygenase ( COX ) family members are associated with a proliferative potential and apoptosis resistance of many cancers . COX-2 is an important molecular target for both therapy and prevention of malignancies .

杀虫剂分子靶标烟碱型乙酰胆碱受体研究进展

Advances in the Molecular Target for Insecticides of Nicotinic Acetylcholine Receptors

作为一类新的分子靶标，miRNA应用于肝癌的诊断、治疗中的应用也得到了广大研究者的认同。

As a new class of molecular targets , miRNA used in the diagnosis of liver cancer , treatment of the majority of researchers agree .

对PC-1基因功能深入研究将有可能为发现新的前列腺癌的诊断治疗分子靶标提供线索。

Further study of PC-1 gene function may provide clue to discover new molecular targets for prostate cancer diagnosis and treatment .

代谢基因工程提高作物产量的分子靶标

Molecular Targets for Increasing Crop Yields by Metabolic Gene Engineering

结肠癌肝转移诊断、治疗相关分子靶标的研究

Studies on Molecular Targets for Predicting and Treating Colon Cancer Liver Metastasis

基因芯片筛选同时参与肺腺癌不同癌变进程的分子靶标

CDNA microarray screening biomarkers which simultaneously participate in different carcinogenesis progression in lung adenocarcinoma

现代新药研发的关键首先是寻找、确定和制备药物分子靶标。

The first key step in the current new drug discovery process is to find , identify and prepare the target proteins for drug molecules .

所有这些基因都负责熟知的药品（诸如抗抑郁药、精神抑制药与包括百忧解、舒马曲坦与安理申等在内的止疼片）的分子靶标的编码。

The genes all encode molecular targets of well-known pharmaceuticals , such as antidepressants , antipsychotics and pain relievers including Prozac , Imitrex , and Aricept .

有利于肿瘤临床诊断与治疗药物分子靶标的确定，有助于揭示肿瘤发生机制及致病基因的生物作用。

The proposed approach is useful for cancer clinical diagnosis and determining treatment of drug molecules target , it also helps to reveal the pathogenesis and biological function of oncogenes .

它基于药物及其生物大分子靶标的知识，通过理论模拟和计算来预测受体与配体间的相互作用，从而指导和辅助药物设计，加快药物开发进程。

Bases on the knowledge of drug and its macromolecule target , it predict the interaction of receptor and ligand by analogizing and calculating . It directs and aids drug design to accelerate the process of drug exploitation .

因此，活性小分子与靶标蛋白质的相互作用是生命中最基本的相互作用之一。

Therefore , the binding of small molecule and the target protein is one of the most basic interactions of life .

因此，探讨卵巢浆乳癌侵袭与转移机制，寻找更有效的分子治疗靶标成为目前国内外分子肿瘤学研究热点。

Therefore , investigating the invasion and metastasis mechanisms of ovarian serous papillary cystadenocarcinoma and searching more effective therapeutic targets become more and more enthusiastic in molecular oncologic research fields .

可以用来寻找其他小分子的分子靶标。

It can be used to find molecular targets for other small molecules . 3 .

随着这部分论文的完成，我们已经建立了识别小分子药物作用靶标和分子通路的通用平台。

With the finish of this work , we have established a common platform to identify targets for small-molecule drugs .

网络靶标概念指的是将病证生物分子网络当作靶标，由此设计和预测最佳的药物干预方式。

The network target treats a disease-specific biomolecular network as a target to help design and predict the best possible treatments .

以前，他们的研发重点一直是新一代的抗组胺药物，鲍蒂斯塔博士说，现在，他们则瞄准了新的分子和细胞靶标来开发新的疗法。

Before , the focus was on next-generation antihistamines , Dr. Bautista said . Now , it 's on new molecular and cellular targets to develop new therapies .

神经母细胞瘤细胞系是神经元发育的良好模型，通过应用蛋白质组学分析技术研究这种模型，可以深入了解神经元分化过程的分子机理，并为肿瘤的临床治疗提供分子靶标。

Neuroblastoma cell lines are good models for neuronal development , through the studies on which molecular mechanism behind neuronal differentiation can be discovered .

该平台利用三维分子相似性方法可对提问化合物分子结构进行靶标及毒副作用预测；也可针对商业化合物库进行虚拟筛选以及骨架跃迁研究。

This platform can perform target or side effect prediction against a query structure based on three dimensional molecular similarity methods ; it can also perform virtual screening or scaffold hopping research on commercial compound databases .

为了阐明昆虫抵御真菌入侵的分子机制以及为提高家蚕抗真菌能力寻找新的分子靶标，我们重点对丝氨酸蛋白酶抑制剂进行深入研究。

To elucidate the molecular mechanism of insect resistance to fungal invasion and seek novel targets to improve silkworm antifungal ability , we focus on in-depth study of the serine protease inhibitors .

通过对棉铃虫蜕皮相关基因的研究，不仅可以为进一步了解昆虫的生长发育和蜕皮激素调控的分子机理奠定基础，而且在此基础上可以发现新的分子靶标，为害虫防治提供新思路。

Through the research of the molting related genes , especial the genes regulated by 20E , we may further understand the molecular mechanism of development and ecdysone regulation , and find the novel molecular targets to effectively control the pest .

这些结果为进一步研究棉铃虫蜕皮的分子机理和检测促蜕皮生长调节剂类化学杀虫剂提供了新的分子靶标。

These findings provided new molecular targets for studying the mechanisms of insect molting and assaying the efficacy of new molting-induced regulatory insecticides .