前药

前药5FC能明显杀伤HeLaY细胞，5FC浓度与HeLaY之间存在对数曲线关系。

Apparently , the prodrug 5_FC killed HeLa_Y cells . There was logarithm cure relationship between5_FC with HeLa_Y .

5-氟尿嘧啶核苷前药脂质体对人喉癌HEP-2细胞株增殖与凋亡作用的影响

5-fluorouridine prodrug liposome inhibits proliferation and improves apoptosis of laryngeal cancer cell line HEP-2

核苷类抗HIV系列前药的化学稳定性及药物动力学研究

Study on Pharmacokinetics and Chemical Stability of Anti-HIV Nucleoside Prodrugs

HIV-1蛋白酶抑制剂前药的研究进展

Progress in HIV-1 Protease Inhibitor Prodrugs

目的探讨TK与CD双自杀基因对肝癌细胞的杀伤作用及旁观者效应，并在前药用量、杀伤效力及旁观者效应强弱等方面，与单自杀基因比较。

Objective To explore the cell killing and bystander effects of double suicide gene on hepatic cancer cells ( HCC ) .

目的探讨UPRT/5FU前药转换酶系统对小鼠胃癌细胞MFC的杀伤效应。

Objective To investigate the killing effect of UPRT / 5-FU Enzyme / Prodrug System on murine gastric cancer .

不同前药联合HSV-tk自杀基因系统对喉癌细胞体外杀伤效应的比较研究

Killing Effects of Different Prodrugs Combined With Suicide Gene HSV-tk on Hep-2 in Vitro

前药研究是提高生物药剂学分类系统中第III和IV类药物口服吸收的有效途径之一。

Prodrug is an effective way to improve the oral absorption of the drugs which belong to Biopharmaceuticals Classification System ( BCS ) class III and IV.

HRP曾被用来转变吲哚前药IAA等类似物为有毒性的药物，用来杀灭活体内的细胞。

HRP was used to transform the prodrug IAA and other indole analogues to toxic drugs to kill cells in vivo .

NO前药JS-K对HL-60细胞增殖、分化的影响

Effects of NO prodrug JS-K on HL-60 cell proliferation and differentiation

本文首次建立了测定血浆中阿德福韦浓度的液相色谱-串联质谱（LC／MS／MS）法，并应用此方法对阿德福韦地匹福酯的临床前药代动力学进行了系统的研究。

A new LC / MS / MS method for determination of adefovir in animal plasma was developed and validated and successfully used in the preclinical metabolism and pharmacokinetics study of adefovir dipivoxil .

结论：七叶树皂苷Ia是前药，人肠内细菌和短乳杆菌粗酶能够转化七叶树皂苷Ia；

Conclusion : The results suggest that Escin Ia was a prodrug and its structure can be converted by human intestinal bacteria and Lactobacillus brevis .

通过观察tk基因修饰细胞生长状况及比较不同前药对喉癌细胞杀伤效应以探讨不同前药作用机理。

The growth state and prodrugs killing effect of tk gene modified cells were used to investigate the expression of tk gene and antitumour effect on Hep-2 cells .

肿瘤单抗&酶/抗癌前药（ADEPT）治疗是一种非常有前景的肿瘤免疫治疗方法，该方法可以增加肿瘤的治疗效果，同时避免严重的全身毒性。

ADEPT is a kind of very promising immune treatment for cancer . The method can be add to result of treatment for cancer , and avoiding seriously systemic toxicity .

综述HIV1蛋白酶抑制剂前药的研究进展。

The progress in HIV-1 protease inhibitor prodrugs was reviewed .

通过联合Ad-CMV-lis及前药lin进行多种肿瘤细胞系的体外及体内抑瘤实验，观查该系统的抑瘤活性及旁观者效应。

A variety of tumor cell lines was treated by Ad-CMV-lis and lin in vitro and in vivo to observe the antitumor activity and bystander effect of the system .

联合前药5-FC和/或GCV作用于转染了CD-TK基因的RM-1细胞，以MTT法检测自杀基因系统对转染后的RM-1细胞的杀伤作用，以未转染的RM-1细胞作对照。

The toxic effects of 5-FC and GCV used alone or in combination on the transfected cells were observed by MTT assay , with the non-transfected RM-1 cells serving as control .

目的探讨腺病毒介导自杀基因联合前药5FC对人胰腺癌的治疗作用。

Objective To determine the efficacy of adenovirus-mediated suicide gene transduction combined with prodrug 5-fluorocytosine ( 5FC ) as a therapeutic protocol for pancreatic cancer .

目的探讨联合应用尿嘧啶磷酸核糖转移酶（UPRT）基因对胞嘧啶脱胺酶（CD）/氟胞嘧啶（5-FC）前药转换酶系统抗瘤作用的增强效应。

Objective To investigate the enhanced antitumor effect of cytosine deaminase / 5 fluorocytosine enzyme prodrug system ( CD / 5 FC ) combined with uracil phosphoribosyl transferase ( UPRT ) gene therapy on gastric cancer xenografts in 615 mice .

生物还原剂不仅可以作为放射增敏剂、化学增敏剂，还可以用于基因向导的酶前药治疗（GDEPT）。

Recently , bio-reductive drugs were combined with GDEPT for the treatment of cancer , in addition to radiation and the chemotherapeutic agents .

本文通过建立测定生物样品中两种新型喹诺酮衍生物CS-940及KNT-009浓度的高效液相色谱-紫外检测法（HPLC-UV），对两种化合物在动物体内的临床前药代动力学进行了系统的研究。

New HPLC-UV methods for the determination of CS-940 and KNT-009 in biological specimen were developed and successfully used in the preclinical metabolism and pharmacokinetics study of these two new quinolones .

在此基础上，依于体内药物代谢原理，按照前药的设计思想，设计并合成了三个新的Darbufelone的Me-too类化合物，其药理作用正在进行中。

Other pharmacological tests of Darbufelone are being carried out . According to drug metabolism theory in vivo and the idea of prodrug design , three new Me-too compounds of Darbufelone were designed and synthesized . Other pharmacological tests are being carried out .

重组人胰高血糖素样肽前药的表达、纯化及生物活性分析

Expression , Purification and Bioactivity of Prodrug of Recombinant Human GLPs

前药在弱酸和中性环境中保持稳定，主要降解成阿昔洛韦。

The main degradation product of the lipidic prodrug was acyclovir .

灯盏乙素酯类前药的合成、理化性质及降解研究

Ester prodrug of scutellarin : synthesis , physicochemical property and degradation

环维黄杨星D的前药改造及生物活性研究

Prodrug structural modifications of cyclovirobuxine D and their biological activity

蛇葡萄素钠在生物介质中稳定性及临床前药代动力学研究

Studies on Stability in Biological Medium and Preclinical Pharmacokinetic of Ampelopsin Sodium

普萘洛尔乙烯酯前药的高效液相色谱对映体分离

Chiral Separation of Propranolol Vinyl Ester Prodrug by High Performance Liquid Chromatography

物质经皮渗透及其研究萘普生前药及其经皮渗透特征

Study on prodrugs of naproxen and their dermal permeability THEORY OF PERMEATION

测定了恶唑烷类前药的水解速度常数。

The hydrolysis rate constants of oxazolidine pro & drugs were determined .