基因重复

基因重复的进行性腓骨肌萎缩症1A型临床与电生理研究

Clinical and electrophysiological study on charcot-Marie-Tooth disease type 1A with gene duplication

Charcot-Marie-Tooth病1A型基因重复诊断研究

The study of gene duplication in Charcot-Marie-Tooth disease type 1A patients

用高度多态性的短串联重复序列检测腓骨肌萎缩征1A型基因重复

Polymorphic short tandem repeats for diagnosis of the Charcot-Marie-Tooth 1A duplication

腓骨肌萎缩症1A型基因重复的检测

Detection of duplication in Charcot - Marie - Tooth disease type 1A

颈区基因重复序列起稳定DC-SIGN结构的作用。

Repeat alleles in neck region can stabilize the structure of DC-SIGN .

以协同进化而言，TCRV和IgVH的基因重复率分别为1.7×10~（-6）和1.6×10~（-6）/基因年。

As for concerted evolution , gene duplicate rates in TCR V and Ig VH are 1.7 × 10-2 and 1.6 X 10-2 / gene / year , respectively .

结论PCR双酶切法检测CMT1A基因重复敏感、快速、准确，适于临床推广应用；

Conclusion The PCR combined with restriction enzyme digestion represented a relatively sensitive and accurate method for detecting gene duplication in CMT1A cases for clinical diagnosis .

耐辐射球菌中的双MutT蛋白由B型基因重复-融合事件而得到。

This suggested that the double MutT domain proteins in D. radiodurans probably resulted from a B-type gene duplication-fusion event .

p35~（Nck5a）基因重复性打靶载体的构建和ES细胞基因打靶研究

Construction of Gene Targeting Vector for Duplicating p35 ~ ( Nck5a ) Gene and Its Application in the Gene Targeting of ES Cells

独立的基因重复-融合事件导致了不同的双MutT／Nudix结构域蛋白中的相似结构。

Independent gene duplication-fusion events resulted in similar domain architectures of different double MutT / Nudix domain proteins .

目的探索适合临床应用的检测腓骨肌萎缩症1A型（CMT1A）基因重复的有效方法。

Objective To study the routine methods that can be easily used in clinics to detect the Charcot Marie Tooth ( CMT ) disease gene duplication .

结论我国PMP22基因重复突变的致病频率为31.9%（36/113），PMP22基因缺失突变是遗传性压力易感性神经病常见的致病原因。

PMP22 duplication rate in Chinese patients with CMT is31.9 % ( 36 / 113 ) . ? PMP22 deletion is the common cause of HNPP .

多重连接依赖的探针扩增这一新方法可用于快速、准确地检测PLP1的全基因重复。

MLPA , which is a newly developed method , is a rapid and reliable technique to detect the whole gene duplication of PLP1 .

我们提出古老的基因重复融合事件来解释这个现象。

We propose an ancient gene duplication-fusion model to explain this observation .

查尔酮合酶基因重复-歧化的遗传学效应

Genetic Effects of Duplication and Disproportionation of Chalcone Synthase Genes

这个超家族的基因重复研究可能对解决这个问题提供一些启示。

Gene duplication in this superfamily may shed light on this issue .

基因重复的研究进展

Progress in the Study of Gene Duplication

基因重复是普遍存在的生物学现象，是基因组和遗传系统多样化的重要推动力量，在生物进化过程中发挥着极其重要的作用。

Gene duplication is universal across all organisms and plays a key role in driving the evolution of genomes and genetic systems .

近年来的高通量数据如：蛋白质与蛋白质互作、基因重复性、基因表达水平以及进化速率等数据的出现极大地促进了基因重要性的预测。

Recent advances in generating high-throughput data such as protein-protein interaction , duplication , gene expression level and evolutionary rate data stimulate the prediction of gene essentiality .

引起遗传性疾病的分子机制有多种，常见的有点突变、小片段插入/缺失突变、拼接位点突变、外显子缺失/重复突变、基因重复和复杂重排及基因拷贝数异常等。

There are multiple molecular mechanisms that can cause genetic disorders such as point mutations , splicing site mutation , insertion / deletion mutations , gene duplication , complex rearrangements and gene copy number abnormalities .

在真核生物基因中重复体DNA占据了非常重要的地位。

Repetitive DNA sequence occupied a crucial position in eukaryotic genes .

芜菁花叶病毒CP基因反向重复植物表达载体的构建及遗传转化

Construction and Transformation of Inverted Repeat of Turnip Mosaic Virus Coat Protein Gene

Gateway重组系统快速构建花生条纹病毒cp基因反向重复序列载体

Quick Construction of Inverted Repeat Vector of Peanut stripe virus cp Gene by Gateway System

雌激素受体α基因TA重复序列多态性与原因不明月经过少的关系

The association of a TA repeat polymorphism in ERa gene with unknown aetiology hypomenorrhea

结果显示亨氏基因CAG重复次数为48

And it came back with a C.A.G. score of 48 .

应用377自动测序仪及相关软件对ER-α基因TA重复微卫星多态性进行基因分型。

Genotyping of the ER-alpha microsatellite polymorphism was performed using ABI 377 automated sequencer and affiliated software .

前列腺癌细胞雄激素受体基因CAG重复序列改变的初步研究

Changes of CAG Repeat Length within the Androgen Receptor Gene in Prostate Cancer Cells

新疆哈萨克族血管紧张素原基因GT重复序列多态性研究

A study on GT repeat sequence polymorphisms of angiotensinogen gene in Kazak of Xinjiang

非同位素PCR方法检测脆性X综合征FMR-1基因CGG重复序列数目

CGG Repeated Number of Fragile X Syndrome Gene FMR-1 Detected by Nonradioactive PCR Test

强直性肌营养不良患者基因CTG重复数与BAEP、TCD、ECG对比分析

Comparative analysis of CTG repeat numbers and BAEP , TCD and ECG in patients with myotonic dystrophy