异常蛋白

淀粉样变性，异常蛋白在组织中积聚的一种疾病，可发生在CD。

Amyloidosis , a disease where abnormal proteins are deposited in tissues , can occur in CD .

大多数细胞内的异常蛋白或长寿命蛋白主要是通过UPS降解。

UPS mainly contributes to the degradation of most intracellular abnormal proteins or long-lived proteins .

二.内质网应激和泛素-蛋白酶体系统可能是PD多巴胺能神经元凋亡的关键因素，内质网应激的早期调节过程就存有泛素-蛋白酶体系统对异常蛋白的降解活动。

Endoplasmic reticulum stress and the ubiquitin-proteasome system may be the PD dopaminergic neuronal apoptosis key factors . Endoplasmic reticulum stress adjustment in the early has contained activity of the ubiquitin-proteasome system degradation to abnormal proteins .

pylori感染与癌前病变-肠化生中APC基因异常蛋白表达有关（Hp~+43.2%vsHp~-13.0%，P<0.05）。

There was significant relationship between H.pylori infection and expression of APC gene protein in precancerous lesions ( IM Hp ~ + 43.2 % vs Hp ~ - 13.0 % , P < 0.05 ) .

26S蛋白酶体是真核生物中一种具有ATP依赖性的蛋白酶复合体，主要通过泛肽途径选择性降解细胞内与代谢调控、细胞周期有关的功能蛋白及异常蛋白，参与多种细胞活动的调控过程。

The 26S proteasome is an eukaryotic ATP dependent protease complex that is responsible for selective degradation of abnomal proteins and naturally short lived proteins relate to metabolic regulation and cell cycle progression by ubiquitin pathway so as to regulate a variety of cellular activities .

创伤血清异常蛋白对巨噬细胞功能作用的研究

Effects of serum abnormal protein from injured rabbits on peritoneal macrophage function

还有一部分（比例不确定）病人可能占10%，有第三种异常蛋白&淀粉样变性。

An uncertain proportion of patients , possibly about 10 per cent , have a third protein abnormality-amyloidosis .

此致瘤调节环境支持中异常蛋白的嵌入可能很大程度上体现了在肿瘤细胞中异质群体内靶目标干预的最佳化。

Anomalous proteins engaged in support of this tumorigenic regulatory environment most probably represent optimal intervention targets in a heterogeneous population of cancer cells .

突变产生异常蛋白，不能行使正常功能调节细胞生长，或引发不可控细胞生长。

The mutation results in a malfunctional protein , which cannot perform its normal task to regulate cell growth or actually induces uncontrolled cell growth .

此病人除有免淋的全部形态学三联症及异常蛋白血症外，还伴有乙型肝炎表面抗原血症及冷凝集素血症。

The patient not only had all the morphologic triad of IBLD with dysproteinemia but also associated with HBsAg and cold agglutinin existing in his blood .

结果：30%MG患者胸腺提取液中存在异常蛋白，其相对分子质量小于14400，而在先天性心脏病患者胸腺细胞培养上清中未见这种蛋白。

Results : There was abnormal protein , which molecular weight was less than 14 400 in the thymus extract of 30 % patients with MG .

研究认为泛素蛋白酶体降解通路失调可导致异常蛋白在细胞内积聚，并进一步引起细胞功能紊乱及变性。

Previous studies suggested that disorders of ubiquitin-proteasome degradation pathway can lead to the accumulation of abnormal proteins in cells , leading to cell dysfunction and degeneration .

我们在此所做的就是精确匹配治疗方案。一种治疗方案针对一种特殊类型的癌症突变细胞和可能激活癌症细胞生长的异常蛋白信号通路。

What we are doing here is precisely matching a treatment to a specific type of cancer cell mutation and abnormal protein signaling pathways that may activate cancer cell growth .

半乳糖诱导白内障大鼠异常晶状体蛋白X（36）与白内障形成的关系

Relationship between abnormal rat crystalline X_ ( 36 ) and galactose-induced cataractogenesis

脑胶质瘤组织PTEN基因异常及其蛋白表达

Study on abnormality of PTEN gene and its expression in human gliomas

DNA的低甲基化可能在异常组蛋白修饰的协同下引起某些T细胞基因的异常活化，导致狼疮自身免疫的发生。

DNA hypomethylation , likely to be cooperating with aberrant histone modification , may induce the activation of some T cell genes and development of autoimmunity in SLE .

骨肉瘤N-ras、c-myc基因异常及其蛋白产物的表达

Alterations of N ras 、 c myc genes and the expression of their proteins in human osteosarcoma

结论SLE患者存在凝血的激活和抗凝系统的异常，蛋白C系统在SLE患者的血栓形成中起着重要作用。

Conclusion There are activation of coagulation and abnormality of anticoagulant system in patients with SLE , and protein C system plays a major role in pathogenesis of the thrombosis in patients with SLE .

帕金森病的主要特征是被称为路易小体（Lewybodies）的异常脑蛋白聚集，而a-synuclein蛋白（简称a-syn蛋白）是路易小体的主要组成部分。

Parkinson 's disease is characterized by clumps of abnormal brain proteins called Lewy bodies of which a-synuclein ( a-syn ) protein is the principal component .

结果提示，一些类型（亚型）的进行性肌营养不良可能与肌肉抑制素Myostatin基因表达异常、蛋白加工障碍有关。

Our data demonstrated that the pathogenesis of some types or subtypes of progressive muscular dystrophy is probably associated with the altered myostatin expression and the processing inhibition of myostatin protein .

目的：研究半乳糖诱导白内障大鼠异常晶状体蛋白X36的出现及其与白内障形成的关系。

Objective : To study the abnormal crystalline protein X36 in cataract SD rat and to explore the relationship be-tween X36 and cataractogenesis .

目的对一个遗传性异常纤维蛋白原血症家系进行表型和基因型分析。

Objective To analyze the phenotype and genotype of a family with inherited dysfibrinogenemia .

结果该例患者反复发生脑卒中，并出现视网膜血管异常、蛋白尿和血尿，眼科检查提示眼底动脉节段性狭窄；

Results The case had recurrent stroke , retinal vessel abnormality , proteinuria and hematuria .

目的：观察阿托伐他汀对异常脂蛋白血症病人的调脂效果。

Objective : To evaluate the effects of atorvastatin on lipid profile modification in patients with dyslipoproteinemia .

结果：异常脂蛋白血症组血液流变多项主要指标及甲襞微循环形态、流态、周态积分较对照组明显升高。

Results : Main indications of hemorheology and unextrapolated area of subungual microcirculation fluxion were significantly raised in individuals with abnormal lipoproteins .

新生鼠神经发育过程中的自发性行为和习惯改变、胆碱能系统功能异常、蛋白表达改变等。

Recently , the authors found that PFOS exposure resulted in spontaneous behavior and habituation , cholinergic system dysfunction , and abnormal proteins expression in neonatal pups .

本检测方法可为羊痒病异常朊蛋白的检测提供技术储备，同时也为传染性海绵状脑病的相关科研提供一种新的技术手段。

This established methods provide both a technological base for the detection of abnormal prion protein and a new technology for the scientific research relation to the Transmissible Spongiform Encephalopathy .

结论对A/G异常血清蛋白的进行电泳分析，有助于了解不同疾病中血清蛋白组分的变化情况，对疾病的临床诊断及疗效观测有较大价值。

Conclusion The results of serum protein electrophoresis analysis with abnormal A / G are useful for understanding the change of segments protein and useful for the diagnosis and treatment of different diseases .

作者简单介绍了正常和异常朊蛋白结构、功能、构象改变及朊病毒种属屏障的研究进展，并提出了目前尚待研究的问题。

This review introduced the advance of the structure , foundation , conformation changing of normal and non-normal prion protein and species barrier of prion , putting forward to the question be researched now .

结果15例患者均有多发性神经病、淋巴结肿大、水肿、异常球蛋白血症及皮肤色素沉着，其他症状包括肝肿大6例、脾肿大9例、性功能障碍12例等。

Results : All 15 patients presented polyneuropathy , enlargement of Lymph Nodes , edema , abnormal globulinemia and hyperpigmented skin . 6 patients were complicated with hepatomegaly , 9 cases with splenomegalia and 12 cases with impotence .