成纤维细胞型

结论：1.培养小鼠睾丸引带细胞呈成纤维细胞型生长，传代后细胞同源性好，存活率高。

Most of the cultured gubernaculum cells were fibroblasts and highly homogeneous . The cell viability was high . 2 .

血管紧张素Ⅱ和醛固酮对心脏成纤维细胞Ⅲ型胶原mRNA表达的影响

Influence of angiotensin ⅱ and aldosterone on type - ⅲ collagen mRNA expression in cultured cardiac fibroblasts

结论硬皮病成纤维细胞Ⅰ型胶原mRNA表达增多，这种表达增多与成纤维细胞自身合成TGF-β1的水平可能无关。

Conclusion The type ⅰ collagen mRNA expression was elevated in SSc fibroblasts , which may be uncorrelated with the TGF - β 1 .

观察了不同浓度牛血浆纤维粘连蛋白（FN）对培养的人牙髓成纤维细胞Ⅲ型胶原、FN表达的影响；

Four concentrations of bovine plasma fibronectin ( FN ) on cultured human dental pulp cells in vitro were studied .

GGPP能明显逆转洛伐他汀对ADPKD囊肿衬里上皮细胞和间质成纤维细胞I型和W型胶原分泌的抑制作用（尸<0.01）。

GGPP was able to reverse the growth inhibition of lovastatin in ADPKD cyst-lining epithelial cells and fibroblasts .

结果川芎嗪可抑制成纤维细胞Ⅰ型胶原蛋白的表达。

Results Tetramethylpyrazine inhibited the expression of collagen I of fibroblast .

黄芪甲苷对心肌成纤维细胞Ⅰ型胶原合成的影响

Effects of Astragalosides on Type ⅰ Collagen Synthesis of Rat Cardiac Fibroblasts

粗纤维调节素对小鼠成纤维细胞Ⅰ型前胶原基因表达的影响

Effect of undulin on expression of type I procollagen mRNA in mice fibroblast

转化生长因子β1对人肾间质成纤维细胞组织型转谷氨酰胺酶表达的调节

Transforming Growth Factor β 1 Regulates the Expression of Tissue Transglutaminase in the Human Renal Interstitial Fibroblasts

雷公藤甲素作用后瘢痕疙瘩成纤维细胞Ⅰ型、Ⅲ型前胶原表达减弱。

Further the expression of procollagen type ⅰ and ⅲ in vitro were decreased after triptolide action .

机械拉伸对人牙周膜成纤维细胞Ⅰ型胶原及蛋白合成的影响

Effects of Mechanical Stretch on Collagen Type ⅰ and Total Protein Synthesis of Human Periodontal Ligament Fibroblasts

结论糖尿病大鼠心脏成纤维细胞短型瘦素受体表达增加与心脏纤维化并存。

Conclusions The coexistence of cardiac fibrosis and increased expression of Ob-Ra mRNA in myocardial fibroblasts were found in diabetic rats .

剂量在10～15Gy之间，成纤维细胞Ⅲ型胶原的合成明显增加。

Following electron irradiation dosages of 10 to 15 ? Gy the synthesis of type ⅲ collagen by fibroblasts were increased prominently .

TNF-α对精氨酸加压素诱导下大鼠心肌成纤维细胞诱导型一氧化氮合酶-一氧化氮系统活性的影响

Effects of TNF - α on changes of inducible nitric oxide synthase-nitric oxide system activity induced by arginine vasopressin in rat cardiac fibroblasts

第2代肌腱细胞与皮肤成纤维细胞Ⅰ型胶原灰度比值为1.09±0.05，Ⅲ型胶原灰度比值为0.93±0.08。

In passage two tenocytes and dermal fibroblasts , grey density ratio was 1 . 09 ± 0 . 05 for type ⅰ procollagen , and 0 . 93 ± 0 . 08 for type ⅲ pro-collagen .

促纤维化细胞因子的释放导致纤维细胞增殖并迁移到肺组织的不同部位，接着分化为不同的成纤维细胞亚型，而这种纤维细胞的分化可能是特发性肺纤维化慢性进程的关键原因。

The release of promote-fibrosis cytokine leads to fibrocellular proliferation and migration to different sites of lung tissue , then differentiate to different fibroblast subtypes , but this kind of fibrocellular differentiation may be the essential reason for the chronic development of idiopathic pulmonary fibrosis .

维甲酸下调高氧暴露下胎鼠肺成纤维细胞及Ⅱ型肺泡上皮细胞MMP-2表达

Retinoic acid down-regulates the hyperoxia-induced expression of MMP-2 in fetal rat lung fibroblasts and type ⅱ alveolar epithelial cell

结论：IPL可直接促进成纤维细胞中Ⅰ型和Ⅲ型前胶原mRNA的转录，该研究部分阐明了IPL除皱的机制。

Conclusions : IPL irradiation can directly promote the mRNA transcription of the type ⅰ and ⅲ procollagen in fibroblasts , which partly suggests mechanism of IPL in wrinkles removing .

采用圆点印迹法评估植物雌激素对成纤维细胞合成1型原胶原蛋白（PC-1）的影响。

By using dot blot method , the effect on procollagen-1 ( PC-1 ) synthesis in neonatal foreskin fibroblasts was also assessed .

用成纤维细胞和I型鼠尾胶原制备真皮类似物。

Cultured fibroblasts were mixed with rat tail type I collagen to form a dermal equivalent .

结果三维系统中瘢痕成纤维细胞内Ⅰ型前胶原蛋白的量远低于后二维培养系统。

Results Observations show that the procollagen synthesis in three dimensional culture system is much lower than the latter .

方法：采用细胞三维培养技术将分段毛囊上皮细胞分别与毛乳头细胞、真皮鞘细胞及真皮成纤维细胞进行器官型培养来重建表皮和毛囊。

Methods : Using organotypic culture model , we combined different subpopulation keratinocytes with dermal papilla cells , dermal sheath cells and fibroblasts to reconstruct hair follicles and epidermis .

常山酮可抑制成纤维细胞合成Ⅰ型胶原，且随浓度增加作用增强，但不影响Ⅲ型胶原的合成。

Halofuginone could inhibit the synthesis of type ⅰ collagen of fibroblasts derived from human scar in a concentration-dependent manner , but had no effects on synthesis of type ⅲ collagen .

前列腺素E2（PGE2）对瘢痕成纤维细胞Ⅰ、Ⅲ型前胶原基因表达的影响

Effects of PGE_2 on type ⅰ and ⅲ procollagen mRNA expression in scar-derived fibroblasts

目的：研究苦参素对成纤维细胞增殖及Ⅲ型原胶原mRNA表达的影响，探讨其抗纤维化的作用机制。

Objective : To study the effect of oxymatrine on fibroblastic proliferation and procollagen mRNA expression in search of effective medicine for liver fibrosis .

方法：用MTT法及Northern杂交分别检测NIH3T3成纤维细胞增殖及Ⅲ型原胶原mRNA的表达。

Methods : The proliferation and procollagen mRNA expression of fibroblast cell was studied with MTT bioassay and Northern blot hybridization .

曲尼司特能抑制正常皮肤和瘢痕疙瘩成纤维细胞Ⅰ、Ⅲ型前胶原mRNA表达，且随着浓度增加这种作用越加明显。

Tranilast could reduce the synthesis of procollagen ⅰ / ⅲ mRNA in normal and keloid fibroblasts . The inhibition ability became more evident when the concentration was increased .

目的：研究强脉冲光（IPL）照射对体外培养的汉族人皮肤成纤维细胞Ⅰ、Ⅲ型前胶原mRNA表达水平的影响。

Objective : To investigate the effects of intense pulse light ( IPL ) on the mRNA expression of type ⅰ and ⅲ procollagen in cultured human fibroblasts .

目的研究激活剂蛋白1（Activatorprotein1，AP1）圈套寡核苷酸（decoyoligodeoxynucleotides，decoyODNs）对成纤维细胞α2Ⅰ型胶原表达的影响，探讨病理性瘢痕的基因治疗。

Objective To investigate the effect of activator protein-1 ( AP-1 ) decoy-oligodeoxynucleotides ( Decoy-ODNs ) on the expression of fibroblast α 2 type I collagen , so as to explore the gene therapy of pathologic scar .

方法：应用逆转录（RT）-PCR和光度检测法测定不同剂量UVA辐照及EGCG处理后，成纤维细胞Ⅰ、Ⅲ型前胶原mRNA的表达水平及培养液中可溶性胶原羟脯氨酸含量的变化；

Methods : The levels of the type ⅰ and ⅲ procollagen mRNA expression of fibroblasts irradiated by different dosage of ultraviolet A and post-treated by EGCG were detected by RT-PCR , soluble collagen hydroxyproline in the cultural medium was determined by photometric determination .