成软骨细胞

背景：骨形态发生蛋白质是目前发现惟一的一类具有成骨能力的细胞因子，它能刺激基质干细胞向成软骨细胞和成骨细胞方向分化。

BACKGROUND : At present , bone morphogenetic protein ( BMP ) is the only cytokine characterized as the ability of osteoblast , and it can promote marrow mesenchymal stem cells ( MSCs ) differentiating into chondroblast and osteoblast .

Ⅱb组无成软骨细胞及软骨囊出现。

No chondroblasts and cartilage appeared in Group ⅱ b.

B组软骨膜明显增厚，软骨基质内细胞浸润也较少，可见成软骨细胞浸润到胶原蛋白材料的结构内。

Group B cartilage membrane thickening , cartilage matrix cell infiltration , visible cartilage cell infiltration into the collagen material structure .

B组软骨膜明显较薄，表现为少见或无，有典型的成软骨细胞出现，见有少量新生的弹力纤维形成。

Group B cartilage thinning of the film , has the rare or not , have a typical cartilage cells appear , see a few new elastic fibers .

资料与方法分析经病理证实的成软骨细胞瘤15例的临床及影像学表现，所有病例均作X线平片检查，9例同时行CT扫描。

Materials and Methods Radiography was taken in 15 patients with pathologically-proved chondroblastomas , of which additional CT scan was done in 9 . Imaging findings were analyzed .

BMP在体内能够趋化、聚集间质干细胞，使其增殖、分化为成软骨细胞和成骨细胞，从而启动成骨的级联过程。

These proteins have the ability to form ectopic bone by inducing primitive mesenchymal cell chemotaxis , proliferation , and differentiation into chondrocytes and osteoblasts .

结论：可将大鼠和成人鼻中隔软骨分为三层，在软骨细胞和前成软骨细胞层边缘部的基质中有SP、CGRP及VIP免疫反应物的存在。

SP , CGRP and VIP existed in chondrocytes and the matrix of border of prechondroblastic layer for the nasal septal cartilages of the rats and human .

结果显示：BMP在胎儿软骨膜、骨膜、成软骨细胞、成骨细胞和血管周围等部位有大量分布；

The result showed that in embryonic bone , BMP was mainly distributed in the periosteum , Perichondrium , chondroblasts . osteoblasts , perivascular messenchymal cells , osteogenic cells .

由于TGF-β本身可诱导hBMSCs成软骨细胞，过高的外源TGF-β浓度下机械刺激的作用会被覆盖。

Because TGF-P itself can induce chondrogenesis , the effect of mechanical load is diminished under high exogenous TGF-P concentration .

成软骨细胞瘤的X线诊断（附19例报告）

X-ray Diagnosis of Chondroblastoma ( A Report of 19 Cases )

长骨成软骨细胞瘤39例X线分析

X-Ray analysis of 39 cases with chondroblastoma of long bone

目的探讨成软骨细胞瘤影像学表现特点。

Objective To discuss the imaging features of chondroblastoma .

目的：探讨X线平片在成软骨细胞瘤诊断中的临床价值。

Objective : To evaluate the diagnostic value of chondroblastoma with X-ray plain film .

良性成软骨细胞瘤（附19例分析）

Benign Chondroblastoma ( Report of 19 Cases )

生长分化因子5诱导兔脂肪干细胞成软骨细胞分化的实验研究

Experimental study on chondrogenic differentiation of rabbit adipose-derived stem cells treated with growth differentiation factor 5

方法取4周新西兰兔关节软骨，经分离成软骨细胞悬液后，置于深低温保藏。

Methods Chondrocytes isolated from the articular cartilage of4 weeks old New Zealand rabbits were preserved in deep hypothermia .

免疫磁珠法分离纯化骨髓间充质干细胞及向成软骨细胞分化

Isolation , purification and directed differentiation to cartilage cell of bone marrow mesenchymal stem cells by immunomagnetic beads method

目的探讨成软骨细胞瘤的影像学特征及诊断价值。

Objective To discuss the imaging features of chondroblastomas , and to evaluate radiography and CT in its diagnosis .

髁软骨各层细胞中成软骨细胞层染色最强，其次是软骨膜层和肥大层。

Condylar cartilage layers of cells into cartilage cells stained the strongest layer , followed by the film and the hypertrophic cartilage layer .

由此成功分离培养骨髓间充质干细胞，并诱导分化为成软骨细胞，对治疗软骨损伤具有重要意义。

So successfully isolated and cultured bone marrow mesenchymal stem cells , and induced to differentiate into cartilage cells , is important to the treatment of cartilage damage .

结果：在诱导第7天可见间充质细胞包绕并迁入骨基质性植入物的间隙，分化成原始软骨细胞、形成软骨组织。

Results : On the 7th day , mesenchymal cells enclosed the engrafted bone matrical transplant , migrated into the gap , differentiated to immature cartilage cell and formed cartilage tissue .

自体软骨细胞的移植取三维培养的自体膝关节软骨细胞，消化成单个软骨细胞后，将细胞悬液注入兔膝关节缺损处，采用自体同侧胫骨上端内侧骨膜覆盖。

The transplant of the auto-chondrocyte the three-dimensional cultured chondrocytes are digested into single chondrocyte , and then , the suspension of the chondrocyte were injected into the defect area of the articular cartilage which are covered by the periost of the proximal wall of the auto-tibia . 3 .

IGF-1对成兔关节软骨细胞体外增殖的影响

The Effect of IGF-1 on Proliferation of Cultured Adult Rabbit Articular Chondrocytes in Vitro

然而成纤维软骨种子细胞的来源依然是亟待解决的问题。

However , cell source of fibrous cartilage is still a problem to be solved .

结果：（1）Ⅱ型胶原和成软骨、软骨细胞的出现相伴随，但肥大、变性的软骨细胞并不表达Ⅱ型胶原。

Results : 1.The appearance of type ⅱ collagen was accompanied by that of chondroblasts and chondrocytes , but hypertrophic and degenerative chondrocytes could not express type ⅱ collagen .

成骨细胞、软骨细胞以及脂肪细胞特异相关或标志基因的表达用RT-PCR检测。

Expression of osteoblast specific genes , chondrocyte specific genes , and adipocyte specific genes were confirmed by RT-PCR .

以组织化学、免疫组织化学和RTPCR，检测成骨细胞、软骨细胞的特异性标志物。

The specific markers of the osteoblasts and chondrocytes were detected by histochemical staining , immunohistochemical staining , and RT PCR .

1，25（OH）2VD3、降钙素对小鼠成骨细胞和软骨细胞增殖及OPG/RANKL/RANK表达影响的实验研究

The Effects of 1 , 25 ( OH ) 2D3 and Calcitonin on Cell Proliferation and OPG / RANKL / RANK Expression in Mouse Osteoblasts and Chondrocytes

结果骨折后5～7d间充质细胞、成骨细胞和软骨细胞内均有IGF-ⅡmRNA表达，为高峰期。

Results IGF - ⅱ mRNA was expression in mesenchymal cells , osteoblasts and chondrocytes on 5 ~ 7 d.

结论：1，25（OH）2VD3能抑制成骨细胞和软骨细胞的增殖及OPG的表达，同时增强RANKLmRNA的表达。

Conclusion : 1,25 ( OH ) 2D3 inhibited cell proliferation and OPG mRNA expression and promoted RANKL mRNA in osteoblasts and chondrocytes ;