氟康唑

氟康唑联合二性霉素B治疗真菌性角膜炎临床研究

A Clinical study on treatment of mycotic Keratitis by Fluconazole and Amphotericin B

流式细胞术检测眼部镰刀菌对两性霉素B和氟康唑的药物敏感性

Susceptibility of ocular fusarium isolates to amphotericin B and fluconazole with flow cytometry analysis

结论念珠菌感染中以白色念珠菌最为多见，药敏结果显示氟康唑、氟胞嘧啶、两性霉素B敏感性高；

Susceptibility results show that Candida infections are highly susceptible to fluconazole , flucytosine and amphotericin B ;

碘酊烧灼联合氟康唑和两性霉素B治疗真菌性角膜炎疗效观察

Curative effects of iodine tincture cauterization combined with fluconazol , amphotericin B in treatment of fungal keratitis

氟康唑致HIV感染者重症多形性红斑型药疹

Stevens-Johnson syndrome caused by fluconazole in a patient with HIV infection

目的比较伏立康唑、氟康唑和两性霉素B在体内对克柔念珠菌的抗真菌活性。

Objective To compare the antifungal activities of voriconazole against Candida krusei with fluconazole and amphotericin B in vivo .

目前临床上常用的抗真菌药物主要有两性霉素B，酮康唑，氟康唑，泊沙康唑、卡泊芬净等。

At present , amphotericin B , ketoconazole , fluconazole , posaconazole , caspofungin are the most common antifungal agents .

目的：测定伊曲康唑、两性霉素B和氟康唑对曲霉和酵母菌的体外抗菌活性。

Objective : To detect in vitro antimicrobial activities of itraconazole , amphotericin B and fluconazole against aspergillus and yeast .

HPLC法分析非PVC软包装氟康唑注射液中的有关物质

Determination the related substances in non-PVC Fluconazole Injection by HPLC

PCR法检测感染实验组及氟康唑治疗组小鼠血清，监测氟康唑对侵袭性念珠菌病的疗效。

PCR is used for monitoring the effects of invasive candidiasis treated with Fluconazole .

进一步应重视联合治疗的可能性，例如使用氟康唑加二性霉素B脂质体。

A possible combination therapy , such as fluconazole and amphotericin B liposome , should be emphasized in the future research .

各药代动力学参数无显著性差异（P>0.05）。试验制剂氟康唑胶囊相对生物利用度F为（104.3±8.5）%。

The relative bioavailability of the tested fluconazole was ( 104.3 ± 8.5 ) % .

2种氟康唑胶囊的主要药动学参数经交叉试验方差分析示无统计学差异（P均>0.05）。

Main pharmacokinetic parameters between test capsule and reference one showed no significant difference based on analysis of variance ( P > 0.05 ) .

结果Etest法和微量稀释法所测酵母菌对氟康唑的总敏感率分别是73.9%和81.5%。

Results The total susceptibility rate of yeasts to fluconazole was 73.9 % and 81.5 % by E test and broth microdilution method respectively .

漫反射FTIR法测定氟康唑片剂的含量

Determination of Fluconazole in the Fluconazole Tablets by Diffuse Reflectance FTIR

氟康唑预防SAP合并疑似深部真菌感染

Prevention of suspicious deep fungal infection with severe acute pancreatitis with Fluconazole

真菌对5-氟胞嘧啶、两性霉素B、氟康唑、伊曲康唑总的敏感率分别为93.0%、98.9%、90.8%、59.8%。

The total sensitivity to 5-Fluorocytosine , Amphotericin-B , Fluconazol and Itraconazole were 93 % 、 98.9 % 、 90.8 % and 59.8 % respectively .

在9种抗真菌药药敏试验中，5-氟胞嘧啶、氟康唑、克霉唑、两性霉素B、制霉菌素有较高的敏感性。

Sensitivity results to nine antifungals showed that 5-flucytosine , fluconazole , clotrimazole , amphotericin B , and nystatin had higher drug sensitivity to these fungi .

分离的菌株对5-氟脲嘧啶、两性霉素B和伊曲康唑的耐药性均<10%，而对氟康唑耐药率则较高。

The separated fungi had a lower degree of resistance to 5-fluorocytosine , amphotericin B and itraconazole ( < 10 % ) and a higher resistance to fluconazole .

RP-HPLC法同时测定复方氟康唑霜中氟康唑、甲硝唑、氯霉素3种组分含量

Determination of Fluconazole , Metronidazole , Chloramphenicol in Compound Fluconazole Cream by RP-HPLC

体外药敏试验显示对伊曲康唑、两性霉素B、制霉菌素高度敏感，酮康唑、克霉唑低度敏感，氟康唑耐药。

The drug sensitive test in vitro indicated that itraconazole , amphotericin B and nystatin were highly sensitive , ketoconazole and clotrimazole were low sensitive , fluconazole was resistant .

建立了HPLC法同时检测洗发水中违禁氟康唑、酮康唑、特康唑和硝酸咪康唑的含量。

A HPLC method was established for the simultaneous determination of fluconazol , ketoconazole , terconazole and miconazole nitrate in illegal shampoo .

应用M13引物PCR指纹法分析假丝酵母菌氟康唑耐药性

Fluconazole resistance in Candida albicans assayed by PCR fingerprinting with M13 primer

以棋盘滴定法测定尼克霉素Z与氟康唑以及尼克霉素Z与特比萘芬的协同作用。

A checkerboard synergy study was carried out to determine the synergistic action of nikkomycin Z with fluconazole or terbinafine .

方法：将真菌性角膜溃疡患者30例分为氟康唑组（n＝16）和酮康唑组（n＝14），比较组间的治愈率和平均疗程。

Methods : 30 cases of fungal keratitis were divided into fluconazole group ( 16 cases ) and ketoconazole group ( 14 cases ) with corresponding drug used .

结果：检测出的念珠菌对特比萘芬耐药，对氟康唑、酮康唑、咪康唑、克霉唑中度敏感，对制霉菌素、伊曲康唑、两性霉素B、氟胞嘧啶高度敏感。

Result : Candida species are resistant to terbinafine , medium susceptible to fluconazole 、 ketoconazole 、 miconazole and clotrimazole , high susceptible to nystatin 、 itraconazole 、 amphotericin B and flucytosine .

感染后12h腹腔注射氟康唑；

Intraperitoneal injection with fluconazole 12h after the infection ;

结论本法简便、易行、灵敏度高，适用于非PVC软包装氟康唑注射液有关物质分析。

CONCLUSION This method was accurate simple and quick , it was can be used on the analysis of non-PVC Fluconazole Injection related substance .

酵母样真菌对5-氟胞嘧啶、两性菌素B、氟康唑、依曲康唑的敏感性分别为98.02%，98.43%，77.38%，77.76%。

The drug susceptibilities to antifungal drugs of the yeast-like fungi were 98.02 % to 5-flucytosin , 98.43 % to amphotericin B , 77.38 % to fluconazole , and 77.76 % to itraconazole .

白色念珠菌对两性霉素B、氟康唑、氟胞嘧啶和伊曲康唑的敏感性分别为100%、94.6%、92.86%和57.1%。

The rate of C. albicans susceptibility to amphotericin B , fluconazole , flucytosine ( 5-FC ) and itraconazole were 100 % , 94.6 % , 92.86 % and 57.1 % , respectively .