灭活酶

结论G-菌是多重耐药菌的主要构成菌，对常用抗菌药物几乎全部耐受，其耐药机制主要是细菌产生ESBLs和AmpC等灭活酶。

Conclusion The major multiply drug-resistant bacteria were gram-negative bacilli , the most common mechanisms of resistance include production by bacteria of antimicrobial-inactivating enzymes , such as ESBLs and AmpC .

抗菌药物耐药机制包括：（1）靶位修饰；（2）产灭活酶；（3）药物渗透力下降；（4）外排泵表达。

Mechanisms of antibiotics resistance includes : ( 1 ) target site modification ;( 2 ) production of inactive enzymes ;( 3 ) decrease of drugs penetrance ;( 4 ) expression of efflux pumps .

从得到的差异表达的蛋白点可知本研究所涉及的耐药机制包括灭活酶或钝化酶的产生，目标靶蛋白的修饰，主动药物转运系统的变化以及细胞外膜的通透性的改变等几种。

From differentially expressed protein spots , antibiotic-resistant mechanism of V. alginolyticus of which in activator or inactive enzyme were produced , target proteins were modified , efflux pump systems and permeability of outer membrane were changed could be known .

本文介绍了具有拮抗细菌耐药性作用的物质的研究进展情况，包括灭活酶抑制剂、药物渗透促进剂、外输泵抑制剂、细菌生物被膜抑制剂、抗菌药物增强剂、耐药质粒消除剂等。

According to the mechanisms of bacterial drug resistance , many antagonists had been developed , including inhibitors of inactive enzymes , accelerators of drug permeation , inhibitors of efflux pump , inhibitors of bacterial biofilm , synergists of antimicrobial and eliminators of resistant plasmid .

细菌对诺氟沙星耐药性的形成可能与细菌外膜通透性改变从而减少抗生素的摄入以及产生灭活酶或钝化酶修饰抗生素有关.本研究为进一步揭示嗜水气单胞菌外膜蛋白与耐药性相关性提供了理论依据。

The change of outer membrane permeability and the generation of inactive enzyme or modifying enzyme might be the reason that bacteria have the resistance to norfloxacin . The research was aim to know more about the correlation between A. hydrophila outer membrane protein and the resistance .

铜绿假单胞菌的耐药机制非常复杂，主要包括灭活酶的产生、药物作用靶位的改变、外膜通透性的降低及药物流出泵的主动外排等。

The mechanism of pseudomonas aeruginosa resistance is very complicated , mainly including inactivated enzyme production , changes in drug action , lower permeability of outer membrane and drug to reduce the flow of active efflux pump , etc. Multi-resistant became a serious problem in pseudomonas aeruginosa infection .

滤除白细胞与病毒灭活对血浆酶等生化指标的影响

The impact of methylene blue plus light method for virus inactivation and leukocyte proof filter on plasma enzymology and a part of biochemistry indexes

背景和目的人类N-乙酰基转移酶2（N-acetyltransferase2，NAT2）是催化芳香胺或杂环胺类化合物和磺胺等肼类药物乙酰化灭活的重要代谢酶。

Background and Aims N-acetyltransferase 2 ( NAT2 ) gene is highly polymorphic .

细菌对四环素类抗生素的耐药主要是获得了有关编码相关蛋白的四环素耐药基因，通过外输泵出机制、核糖体保护机制及产生灭活四环素的钝化酶机制等介导。

The resistance of bacteria to tetracyclines is mainly by resistance genes coding efflux proteins , ribosomal protection proteins or enzymatic inactivation of tetracycline .