组蛋白基因

对果蝇S期细胞内组蛋白基因的原位定量分析

In situ quantitative analysis of Drosophila histone gene in S-phase

Hir/Hira基因产物HIR/HIRA为组蛋白的伴侣蛋白，最先作为组蛋白基因表达的一种负调节因子从酵母中被鉴定出来。

HIR / HIRA , one of the histone chaperones , encoded by Hir / Hira ( histone regulation ) genes , were initially identified in yeast as negative regulators of histone gene expression .

金鱼H1组蛋白基因及其N端片段的克隆、表达及抗菌活性

Cloning , Expression and Antibacterial Activity of Histone H1 and Its N-terminal Peptide from Carassius auratus

非组蛋白基因6（mnh6）和Ⅲ型膜整合蛋白（mtp1）是稻瘟病菌的两个功能未知的基因。

A nonhistone 6 ( MNH6 ) and a type-III integral membrane protein ( MTP1 ) are two unknown proteins in functions of rice blast fungus .

在组蛋白基因群中存在着一些保守的序列和重复结构表明组蛋白基因的进化是采取生与死的进化模式并伴随着强的纯化选择压力，使得该基因群变异较少以保持其基本功能。

The presence of the series of conserved sequences and reiterated sequences was consistent with the view that mollusc histone gene cluster arose by duplicating of an ancestral precursor histone gene , the birth-and-death evolution model with strong purifying selection enabled the histone cluster less variation and more conserved function .

两个人组蛋白H1基因的亚克隆和它们启动子核苷酸顺序的比较

Two subclones of human histone H1 genes and comparison of their promoter sequences

普通小麦编码组蛋白H3基因的克隆与分析

Molecular Cloning and Analysis of Histone H3 Genes from Triticum Aestivum

提取人染色体DNA作为模板，利用一对设计引物扩增获得了人组蛋白H4基因片段（316bp）；

Human genome DNA was extracted then as template , human histone H4 gene ( 346 bp ) was amplified by PCR .

本研究从盐胁迫处理的水稻幼苗组织中分离了一个新的水稻组蛋白H3基因RH3.2A，编码具有136个氨基酸残基的多肽，与多种植物的组蛋白H3蛋白具有高度的氨基酸一致性。

RH3.2A was cloned through RT-PCR from salt-treated rice seedlings . This gene encoded a protein of 136 amino acid residues that were similar to some plant histone H3 proteins reported previously .

DNA甲基化、组蛋白修饰与基因沉默

DNA Methylation , Histone Modifications and Genes Silencing

水稻组蛋白H3基因的分离和组织结构分析

Isolation and Organization Analysis of Histone H , Genes from a Rice Genomic Library

这些酶通过粘附于所谓的化学剂乙酰组蛋白来激活基因，像线圈一样的蛋白以紧密创伤形式缠绕着DNA。

These enzymes activate genes by attaching chemicals called acetyl groups to histones , the spool-like proteins that hold DNA in a tightly wound form .

第3组LEA蛋白及其基因研究进展

Research Progress in Group 3 LEA Protein and Gene

染色质免疫沉淀法是研究染色质结构的首选方法，它不仅可用来研究体内反式因子与DNA的相互作用，也可以用来研究组蛋白修饰与基因表达的关系。

Chromatin immunoprecipitation assay ( ChIP ) provides a powerful tool to analyze the interaction of trans-acting factors with specific chromatin regions in vivo , as well as the role of histone modifications in gene regulation .

目的构建含A组链球菌M蛋白基因（emm基因）1型和3型特异性抗原决定簇基因的重组质粒。

Objectives To construct a recombinant vector containing fragments of emm 1 genes and emm 3 gene that are the type specific epitopes of streptococcus pyogenes .

通过第3章的研究，我们利用蛋白酶基因保守区引物得到了6个蛋白酶基因片段，获得了一个可能是蜡质芽孢杆菌组特异的蛋白基因，进一步丰富了Bt毒力相关基因的研究。

In chapter 3 , we obtained 6 DNA fragments of protease genes and a gene fragment , which might be B. cereus group specific genes , by primer pairs specific for the conserved regions of Bt protease genes .

弓形虫组蛋白H3.3编码基因的亚克隆及序列分析

Subcloning and homology analysis of histone 3.3 protein encoding gene of Toxoplasma gondii

组蛋白修饰在基因转录调控中占有重要地位，在组蛋白修饰酶HATs、HDACs、HMTs的共同作用下控制着染色质的结构和基因的表达，从而参与特定位点的基因转录调控。

Histone modifications plays an important role in transcriptional regulation . Histone modification enzymes , such as HATs , HDACs , HMTs control the chromatin structure and gene expression , thus participate in gene transcription regulation of specific sites .

对第3组LEA蛋白及基因的研究表明，这些基因的表达或蛋白累积与植物的渗透胁迫抗性呈正相关，并已初步证实了第3组LEA基因可能具有干旱保护功能。

The investigations of the group 3 LEA protein and gene showed that these gene expressions or protein accumulation had positive correlation with the botanical osmotic pressure , and it has confirmed that the group 3 LEA gene may have the function protecting from drought .

目的：组蛋白修饰在基因表达调控等多种生物学过程中起着重要作用，是表观遗传中重要的调控机制之一。

AIMNESS : Histone modification as one of the key epigenetic regulation mechanisms plays critical roles in various biological processes , including regulation of chromatin structure dynamics and gene expression .

目的DNA甲基化和组蛋白乙酰化是基因表达调控的主要形式。

Objective DNA methylation and chromatin modification of histone acetylation are two global mechanisms that regulate gene expression .

经RNA干涉试验，确定过氧化氢酶基因、髓鞘蛋白脂蛋白基因、组蛋白乙酰转移酶基因是外周血淋巴细胞中Clock基因下游的钟控基因。

Three of the 10 cDNA were identified as the clock-controlled genes ( CCG ), that is , the catalase , myelin proteolipid protein ( plp ) and histone acetylase gene .

绿脓杆菌外毒素A与人组蛋白H3嵌合蛋白基因克隆及表达的研究

Study on the Cloning and Expression of Fusion Gene for Pseudomonas Exotoxin A and Human Histone H3

一组导向融合蛋白的基因工程研究

A Study of Genetic Engineering on Several Targeting Fusion Protein Drugs

鉴定了具有不同结构的4组编码蛋白的抑制基因。

Four groups of inhibitor-like genes encoding proteins with diverse structures were identified from wheat .

组蛋白乙酰化促进基因表达，而去乙酰化则抑制基因表达。

Histone acetylation contributes to expression of gene , while histone deacetylation leads to repression of gene expression .

组蛋白乙酰化与基因转录等生物效应有密切的关系，组蛋白乙酰化主要是由组蛋白乙酸转移酶催化的。

Histone acetylation has a close relation with some biological effects such as gene transcription , and is catalyzed by histone acetyltransferases .

水稻组蛋白末端修饰酶基因的功能研究水轮机修复专用机器人末端关节摩擦补偿

Functional Analysis of Histone Modification Enzymes in Rice Research on Friction Compensation on End Joint Maintenance by Hydraulic Turbine for Special-purpose Robot

组与组之间，NS2蛋白基因核苷酸同源性为94%～95%，氨基酸同源性为95%～97%。

The two groups shared 94 % 95 % and 95 % 97 % sequence identities at the nucleotide and amino acid levels , respectively .

另外，根据近年来表观遗传学研究进展，组蛋白的泛素化，甲基化，乙酰化等修饰作用共同形成了组蛋白密码，在基因转录调控中起关键性作用。

Moreover , based on the epigenetic research progress in recent years ," histone code " that is including modification of histone ubiquitination , methylation , acetylation , etc. , plays a crucial role in the regulation of gene transcription .