致畸作用

乙醇对金黄地鼠致畸作用的研究

A study of ethanol induced teratogenesis in golden hamster

本文应用小鼠全胚胎培养技术，通过妊娠d8分别ip5,10,15和20mg·kg-1环磷酰胺（CP），研究了该药对器官原基形成期胚胎的致畸作用，并对其致畸机理作了初步探索。

Using the mouse whole embryo culture technique , the teratogenesis induced by cyclophosphamide ( CP ) ( 5 , 10 , 15 , 20 mg · kg - 1 , ip ) and its mechanism were investigated in mice on d 8 of gestation .

目的观察在着床期给予维生素AD滴剂对小鼠的致畸作用。

Objective The teratogenicity of Vitamin AD guttate was investigated on the mice .

维生素AD滴剂对着床期小鼠的致畸作用

Teratogenicity of imbedding mice with Vitamin AD guttate

来曲唑对SD大鼠促排卵及致畸作用的研究

Study of Letrozole 's Ovulation Induction and Teratogenicity in SD Rats

阿司匹林对SD大鼠致畸作用的研究

Study of the teratogenicity of acetylsalicylic acid in SD rats

敌枯双和环磷酰胺对SD大鼠胚胎致畸作用比较

Embryo Malformation Effect Comparison of Bis-A-TDA and Cyclophosphamide

来曲唑对SD大鼠的子宫内膜容受性、生殖能力与致畸作用的影响

The Effect of Letrozole on the Endometrial Receptivity 、 Reproductive Capacity and Teratogenicity in SD Rats

麒麟菜膳食纤维对SD大鼠30天喂养实验和致畸作用

Thirty days feeding experiment of SD rats with die fary fibre from Eucheuma and the teratogenicity

为了了解仙人掌粉对SD大鼠胚胎致畸作用的影响。

In order to study teratogenic effects of Opuntia milpa alta flower on embryos of SD rats .

结论：在本实验条件下，厄多司坦对SD大鼠无致畸作用。

Conclusion : The results indicated that Erdosteine bad no teratogenic effect on SD rats in this experiment .

其作用机制可能是在细胞有丝分裂的过程中，造成DNA和染色体的损伤，致使染色体发生突变、断裂，从而表现出潜在的致畸作用。

The mechanism of action possibly damage chromosome in the process of cell caryomitotic resulting in the chromosome produce idiovariation and fragmentation thus display carcinogenesis and teratogenicity .

没有检测到性畸变个体与正常雌性螺在基因水平的差异，推断有机锡类污染物的致畸作用不在DNA水平。

There is no difference in molecular level between normal female and imposex individuals . It inferred that imposex induced by organotin pollution does not show out on the DNA level .

结论HCY对胚胎细胞分化的影响更为显著，对大鼠致畸作用不明显。

Conclusion HCY obviously inhibited the cell differentiation than proliferation , while it is not a potent teratogen for rat .

背景与目的：研究全反式视黄酸（All-TransRetinoicAcid，RA）对小鼠胚胎腮弓的致畸作用及其可能的致畸机制。

BACKGROUND & AIM : To investigate the branchial arch malformations in all-trans retinoic acid ( RA ) - treated mouse embryos and its possible pathogenic pathways .

目的：用ICR小鼠研究重组葡激酶（r-SAK）的致畸作用。

Purpose : To research the teratogenic effect of recombinant staphylokinase ( r-SAK ) on ICR mice .

辉瑞称，虽然未做过EMS的健康危险人体研究，但动物试验已证明其有致癌和致畸作用。

Pfizer said that while no human studies have been done on the health risks posed by EMS , animal studies have linked it to cancer and birth defects .

由维甲酸诱导形成的NTDs模型在科学研究中已经得到了广泛的应用，但其具体的致畸作用机制尚未见文献报道。

ATRA-induced NTDs model have been widely used in the scientific researches , but the mechanism has not been reported since now .

沙利度胺（酞胺哌啶酮thalidomide）属于非巴比妥类药物，最早作为镇静止吐药物用于临床，后发现具有严重的致畸作用而被禁用。

Thalidomide , a non-barbiturate drug , is used as a sedative antiemetic drug , and shows a significant teratogenic effect , has once been banned .

畸形胚胎头部表皮细胞中很少有HGC的分化或HGC分化不完全，其形态结构也呈现畸形。苄普地尔对小鼠的致畸作用

The deformed embryo had little differentiation of HGC or with incomplete differentiation . Deformed Effect of Bepridil on Mice Embryo

YF-1杀菌剂对小鼠致畸作用研究

Study on Teratogenic Effects of YF-1 Germicide in Mice

维生素A和3-甲基胆蒽体外致畸作用及其与GSH-GST变化的关系

The Effects of Vit A and 3-MCA on GSH-GST in Teratogenicity in vitro

结果表明：PsD-044对孕鼠无母体毒性效应，胚胎毒性和致畸作用。而在同一实验条件下的阳性对照物诱发胎鼠的致畸率高达14.1%。

The results suggest that the maternal toxicity , embryotoxicity and teratogenic effects of PsD-044 were not found , however , the malformation induced by known teratogen was as high as 14.1 % .

对大鼠无明显致畸作用。

There is no significant effect of deformation to the mice .

[目的]探讨YF1杀菌剂对小鼠的致畸作用。

To study teratogenic effects of YF 1 germicide in mice .

转溶菌酶基因水稻稻米毒性与致畸作用试验

Safety assessment of transgenic rice with lysozyme gene from T4 phage

昆虫病毒对胚胎的致畸作用研究

Studies on the malformation of vertebrate embryoes effectes by insect viruses

人参花蕾提取物致畸作用的试验研究

Experimental study on the teratogenic effect of ginseng bud extract

皮下注射丙烯腈对大鼠致畸作用研究

Study on Teratogenicity of Acrylonitrile in Rats by Subcutaneous Injection

大鼠口服红景天致畸作用的研究

The Teratogenic Effect of Rhodiola by Oral Administration in Rats