靶生物

目的：检测新分离的灭蚊真菌（Pythiumsp.代号GY1938）对非靶生物家蝇（Muscadomesticavicina）幼虫的安全性。

Objective : To test if the newly isolated mosquito-killing fungus ( Pythium sp. , GY1938 ) is safe to domestica fly larvae ( Musca domestica Vicina ), a non-target organism other than mosquito .

用斑马鱼急性毒性试验考察其对非靶生物的毒性。

Acute toxicity on non-target organisms was determined using Zebrafish as a bioindicator .

三唑磷农药对三种非靶生物的毒性和安全评价研究

Study on Toxicity and Safety Evaluation of Triazophos on Three Types of Non-target Organisms

以原生动物群落为靶生物，对高效氯氰菊酯的毒性进行了试验研究。

The toxicity of beta-cypermethrin with protozoan community as target organism was studied with test .

它们的使用在作用于靶生物的同时，也对水生态系统中的其它非靶生物的生存和生长产生影响。

They also affect the non - target organisms in the aquatic ecosystem while they are employed to act upon the target organisms in aquaculture .

随着转基因作物的大规模商业种植，其对非靶生物的安全性问题已经成为转基因生物风险评估的重要内容。

With the commercial planting of transgenic plants on a large scale , their impacts on non-target organisms have become an important part of risk assessment of transgenic organisms .

拟除虫菊酯是一种仿生类农药，因其具有快速击倒，杀虫效能高，在环境中低残留及对人畜等非靶生物低毒等特点被广泛用于农业害虫和卫生害虫的防制。

Pyrethroid is one kind of bionic pesticides with characters of quick knocking down the pest , high pesticide efficiency , low retaining in the environment , and little danger to non-target biology .

目的通过星点设计-效应面法优化替硝唑结肠靶向生物黏附片处方。

OBJECTIVE To optimize the formulation of tinidazole colon-targeted bioadhesive tablets by the central composite design-response surface methodology ( RSM plus CCD ) .

既然市场上有很多靶向生物技术药物，那么研究者正开始试验两个靶向药物是否会比一个更好些。

Now that there are several targeted biotech drugs on the market , researchers are starting to test whether two targeted drugs are better than one .

其中，在功能蛋白质组领域内，疾病蛋白质组学在医学和生物制药方面具有发现新分子药靶、生物标志物的巨大的潜力。

In the field of functional proteomics , the human disease proteomics shows great potential in the discovery of new molecular targets and biomarkers for medicine and biopharmacy .

摘要目的：建立稳定整合的细胞株，为研究外源基因定位整合机制及其对靶细胞生物特征影响，建立一个生物模型。

Objective : To establish a stable cell line and employ the cell line as a model to study target integration of exogenous cDNA and modulation of gene expression .

研究一种新型的利用毛细管作为载体检测靶DNA的生物传感器的可行性。

This study investigated the feasibility of capillary as carrier for DNA detection .

结果：（1）建立了以CPGDNA为靶点应用生物传感器筛选抗炎中药的技术平台；

Methods : ( 1 ) CpG DNA , the target , was immobilized on the biotin cuvette of biosensor .

以cpGODN为靶点应用生物传感器技术筛选抗炎中药

Screening of anti - inflammatory Chinese traditional herbs targeted CpG ODN using biosensor technology

方法：用L929细胞作靶细胞的生物测定法，检测与EsA共育的受LPS刺激的人外周血单核细胞上清中TNF的含量。

Methods : determining the TNF level of supernatant of human peripheral monocytes incubated with LPS and EsA by bio assay .

抗分子靶点的生物制剂作用机制提出了下面的问题：在II和III期的对照试验中，那些应该是第一和第二终点事件。

The mechanism of action of biological agents against molecular targets has raised the question of which should be the primary and secondary endpoints in controlled phase II and phase III trials .

报道了靶DNA／生物素化λDNA探针／亲合素／Bio－BSA（TG）－DTPA－Eu~（3＋）体系在核酸杂交分析中的应用。

Here we reports a new detection method for λ DNA through the system of target DNA / Bio-DNA probe / Avidin / Bio-BSA ( TG ) - DTPA - Eu3 + .

生物靶区与生物适形放疗研究进展

Advances in research on biological target volume and conformal intensity-modulated radiotherapy

以肿瘤低氧为靶点的生物还原剂的研究进展

Recent advances in the study of bioreductive drugs targeted tumor hypoxia

通过体外构建生物膜模型，以变形链球菌毒力因子GTF、FTF和Pac为示踪靶，比较在生物膜（牙菌斑）状态下和浮游状态中不同时期Sec蛋白功能的差异；

We build an in vitro biofilm model and using GTF , FTF and Pac as tracer targets to compare differences about the function of secA in planktonic culture , biofilm condition and different periods in the process of biofilm maturation .

抗感染治疗新靶点&细菌生物膜

A New Anti-infection Treatment Target : bacterial Biofilm

基因转运需要合适的载体，理想的基因转运系统，应具有较高的基因转染效率、良好的靶向性和生物相容性、较高的稳定性及生物可降解性。

An ideal gene transport system should have high gene transfection rate , favourable target and biocompatibility , fine stability and biological degradation .

联合使用靶向性氙生物大分子探测器，我们应该可以研究肺中的气体交换，探测最早阶段的癌细胞。

Used in combination with a target-specific xenon biomolecular sensor , we should be able to study the gas-exchange in the lung and detect cancerous cells at their earliest stage of development .

磁性高分子微球是一种兼具磁性材料、高分子材料的功能性材料，其在肿瘤靶向治疗、生物分离，磁共振成像等生物医学领域具有广泛的应用前景。

Magnetic polymer microspheres are a kind of novel functional materials , which exhibit excellent applications in biomedical fields including tumor target therapy , bioseparation , magnetic resonance imaging and so on .

不断开发新的抗肿瘤药物给药系统，提高药物的靶向性和生物利用率，降低毒副作用，改善治疗效果，是自然医学界专家不断实践和探索的方向。

The direction of practice and exploration of the medical experts is to develop new anticancer drug delivery systems constantly , to improve targeting and bioavailability of the drugs , to reduce toxicity of the drugs and improve the therapeutic effect .

功能性高分子磁性纳米复合材料是一种新型材料，因其兼具高分子材料、磁性材料和纳米材料的性能，在细胞分离和肿瘤靶向治疗等生物、医学领域具有非常广泛的应用前景。

Functional magnetic polymer nano-material is an advanced material . It combines the properties of polymer materials , magnetic materials and nano-materials . It has been widely applied in cell separation , targeted cancer therapy , biological and medical field , especially in cancer treatment .

有高度靶向性的介入技术与靶向输送的生物技术的良好结合，具有创伤小、效率高、治疗效果强、系统不良反应相对小的优势。

The combination of targeting biological therapies and high-targeted interventional technique holds advantages of minimal invasion , accurate delivery , vigorous local effect , and less systemic adverse reactions .

方法：综述DNA与其靶向分子的作用方式以及DNA为作用靶的生物活性筛选系统跟踪分离天然植物药活性成分的情况。

METHODS : Review interaction styles of DNA with DNA targeting molecules and bioassay guided isolation of active principles from natural medicinal plants .

结论初步证明了胰岛素作为米托蒽醌的载体，能提高药物的肿瘤靶向性，降低不良反应，并保持药物疗效，为肿瘤主动靶向生物大分子载体设计提供了新的思路。

CONCLUSION MIT-INS has tumor-targeting property with enough anti-tumor activity , and insulin , as the vector of anti-tumor drugs , can improve target effect with low side effect .