抗雄激素

抗雄激素物质氟他胺作用于受孕SD大鼠引起尿道下裂的机制研究

Mechanism of Antiandrogen Flutamide Causing Hypospadias on Pregnant SD Rat

TURP结合抗雄激素干预治疗中晚期前列腺癌36例

Evaluation of the efficacy of TURP combined with antiandrogen therapy in patients with advanced prostatic cancer

34例晚期前列腺癌病人在接受抗雄激素治疗前作前列腺雄激素受体（AR）定量测定，以了解AR值在抗雄激素治疗中的作用。

Androgen receptor ( AR ) quantitative analysis was performed prior to anti androgen therapy in 34 patients with metastatic prostatic carcinoma .

非甾体抗雄激素药物Flutamide的合成

Synthesis of nonsteroidal antiandrogen flutamide

BPA兼有雌激素和抗雄激素样活性，围生期母体BPA暴露可影响雄性子代大鼠大脑皮层的结构，以及大脑皮层和海马神经元的形态发育，说明发育中的脑是对BPA敏感的靶器官。

BPA has both estrogenic and anti-estrogenic action . Perinatal exposure to BPA profoundly disrupts structure and development of the brain cortex and the morphological development of hippocampal neuron . It means that the developing brain is a sensitive target organ to BPA .

方法进展期前列腺癌患者40例，去势术后，未用任何抗雄激素药物，分别于术前、术后1周及1、3、6、9、12个月，观察血清总睾酮和PSA变化。

Methods A total of 40 consecutive advanced prostate cancer patients not treated with any anti-androgen medications 12 months after castration were enrolled . Serum levels of testosterone and prostatic specific antigen ( PSA ) were obtained just prior to castration , and 1 week and 1,3,6,9,12 months after castration .

方法选择33例晚期Pca患者，给予黄体激素释放激素类似物（LHRH-A）+抗雄激素药物进行药物去势治疗，根据Gleason评分分为2~5分组、6~7分组、8~10分组，对3组血清PSA变化进行分析。

Methods : We treated metastatic prostate cancer patients with luteinizing hormone-releasing hormone analog , ( LHRH-A ) and androgen ablation drug ( Flutamide ), and combined with the change of Gleason score and serum PSA level , We have a statistical analysis elevate the efficacy of treatment .

裸小鼠人肝癌移植模型的抗雄激素治疗

Antiandrogen treatment for nude mice model with ectopic transplanted human HCC

醋酸棉酚抗雄激素作用及其对雄激素受体影响

Antiandrogen Effect of Gossypol and Its influence on Androgen Receptor

目的采用抗雄激素类药物氟他胺诱导建立大鼠尿道下裂动物模型，为进一步研究尿道下裂发病的分子作用机制和治疗提供理论和实验依据。

Objective To establish a rat model of hypospadias by flutamide to further studying molecular mechanisms of hypospadias etiology .

一旦细胞转变成激素非依赖型，抗雄激素治疗失去效果，疾病则迅速发展。

When the cancer cells change to hormone-dependent , the anti-androgen therapy will be in-effective and the disease worsen rapidly .

鉴于其远期的重大影响，环境抗雄激素以及相关的环境和生殖问题的研究已经成为目前研究的热点。

Respecting their long-term great effect , environmental antiandrogen and studies of correlated environmental and reproductive problems become hot spots of researches .

对中分化前列腺癌止痛效果较好。结论应用同位素联合抗雄激素综合治疗前列腺癌骨转移是一种有效的骨痛姑息治疗技术。

Conclusion The application of isotope with anti-androgen in treating osseous metastasis of prostatic carcinoma is an effective palliative way for ostealgia .

而长期应用抗雄激素药物去势治疗，则可使激素依赖性前列腺癌逐渐转变为激素非依赖性前列腺癌，预后极差。

While the long-term application of antiandrogen drug castration , can make the hormone independent prostate cancer transforms gradually to hormone-independent prostate cancer , The prognosis is poor .

是一种抗雄激素的非皮质类固醇，它可以作为治疗晚期前列腺癌的辅助用药，也可能在治疗早期前列腺癌方面起重要作用。

An antiandrogen non-corticosteroids can be used treating prostate cancer in advanced stage as assistant drug , may also for treating prostate cancer in the early stage to play an important role .

治疗办法包括服用激素避孕药，促使卵巢停止产生睾丸激素和其他激素，服用通常用于治疗前列腺癌的氟他胺等抗雄激素药物，以及针对代谢问题服用胰岛素增敏剂。

Treatments include hormonal contraceptives to prompt ovaries to stop producing testosterone and other hormones , plus anti-androgen medications like flutamide , usually used to treat prostate cancer , and insulin sensitizers for metabolic issues .

比卡鲁胺是一种新型的非甾体类抗雄激素药物，临床上是与促黄体（生成）激素释放激素类似物合用或配合阉割手术，用于晚期前列腺癌的治疗。

Bicalutamide is a nonsteroidal pure antiandrogen . It is used at a dosage of 50 mg once daily in combination with a luteinizing hormone-releasing hormone analogue or surgical castration for the treatement of advanced prostate cancer .

自1941年至今，抗雄激素治疗仍是这种疾病主要的治疗手段，大多数肿瘤最初反应良好，瘤体萎缩，反映对雄激素的依赖。

Since 1941 , antiandrogen therapy has been the mainstay treatment for this disease , and the majority of PCa responds to antiandrogen therapy by temporary remission in its initial stages , reflecting a dependence on androgen .

结论Gen可明显抑制小鼠BPH，降低BPH小鼠血清睾酮水平，提示其抗BPH作用机制可能涉及抗雄激素作用。

Conclusions Gen could obviously inhibit BPH and decrease serum testosterone level , which suggests that the inhibition mechanism of Gen on BPH might be involved in anti-androgen .