丙咪嗪

以HPLC法测定附子甘草配伍对丙咪嗪血药浓度的影响

Blends by the HPLC Law Determination Monkshood Licorice to the Imipramine Medicine Generation of Dynamics Influence

这说明D1受体参与了丙咪嗪的抗抑郁作用。

This indicates that D1 receptors are involved in the antidepressant effects of imipramine .

方法：以丙咪嗪为阳性对照药，采用小鼠强迫游泳实验和利舍平拮抗实验，观察MC对小鼠游泳不动时间和利舍平诱导的小鼠体温降低的影响；

Methods : Imipramine as the positive contrast medicine , effects of MC on the depression behavior of mice were observed by forced swimming test and reserpine antagonist test .

方法采用ICR雄性小鼠，分为给药组（盐酸丙咪嗪）和对照组，通过强迫游泳实验，观察预先训练、体重和水深对不动时间的影响。

Methods Male ICR mice were divided into drug groups ( imipramine hydrochloride ) and control groups ( distilled water ) to undergo forced swimming test .

方法：采用双盲对照研究方法将200例符合ICD-10抑郁障碍诊断标准的住院或门诊患者，随机分组接受吗氯贝胺（300-600mg·d-1）或丙咪嗪（75-250mg·d-1）治疗6周。

Methods : In a randomized , double-blind and comparative-controlled study , 200 patients with major depression ( ICD-10 criteria ) were randomized to receive imipramine ( 75-250mg · d-1 ) or moclobemide ( 300-600mg · d-1 ) for a 6-week course of therapy .

丙咪嗪和西沙必利治疗功能性消化不良的对比研究

Comparative study on teatment of functional dyspepsia by imipramine and cisapride

丙咪嗪对脑外伤后大鼠海马内神经元再生的促进作用

Imipramine promotes regeneration of hippocampus neuron after traumatic brain injury in rat

三甲丙咪嗪对精神分裂症症状的影响

A study on the influence of trimipramine to the symptoms of schizophrenia

药物不良反应发生率丙咪嗪组高于氟西汀组。

The side reactions in imipramine group was highter than in fluoxetine group .

丙咪嗪对人血小板胞浆游离钙的影响

Effect of Imipramine on the Cytoplasmic Free Calcium in the Platelets of Human

脑~3H&丙咪嗪结合动力学研究

The Kinetic Study of ~ 3H Imipramine Binding

丙咪嗪对慢性应激性抑郁易化吗啡行为敏感化的影响

Effects of Imipramine on Behavioral Sensitization of Morphine in the Chronic Mild Stress-depressed Rats

被诱导的大鼠丙咪嗪的体内代谢加快，甘草和五味子与丙咪嗪合用时药代动力学发生改变。

The metabolism of imipramine is quickened , and the pharmacokinetics of imipramine is changed .

结论丙咪嗪能够与颅脑创伤协同作用共同促进海马内神经元的再生。

Conclusion Treatment with imipramine for traumatic brain injury may promote neurogenesis of hippocampus neuron .

他们用了盐酸丙咪嗪和其他药-，硫醚嗪，谁知道。

And they did have Tofranil and other things -- Mellaril , who knows what .

目的评价氯氮平合并丙咪嗪对衰退期精神分裂症阴性症状的治疗效果。

Objective To evaluate the effect of clozapine combined with imipramine on the negative symptoms of deteriorated schizophrenia .

小鼠灌胃分别给予4个剂量同前的姜黄素，花生油和盐酸丙咪嗪。

Curcumin was give as above at 4 doses , and groundnut oil and imipramine were also given .

主要代谢产物去甲丙咪嗪药时曲线符合一室线性动力学。

The concentration-time curve of desipramine , the major metabolite of imipramine , fitted in with a one-compartment kinetic model .

目的：观察丙咪嗪治疗间质性膀胱炎的疗效。

Objective : To observe the effects of the tricyclic antidepressant Imipramine on patients with interstitial cystitis ( IC ) .

方法使用丙咪嗪、西沙必利治疗4周，然后进行疗效比较。

Methods In the end of 4 weeks of the therapeutic duration with imipramine and cisapride , the effectiveness were evaluated .

丙咪嗪单用及与尼莫地平合用对小鼠脑内单胺递质含量的影响

Effect on contents of monoamine transmitters in the brain of the mice by imipramine in single and combining use with nimodipine

到了60年代中期，第一代抗抑郁药盐酸丙咪嗪产生了。

Well , you know , in the middle ' 60s , the first antidepressants came out . Tofranil was the first .

目的：评价丙咪嗪配合认知疗法对抑郁症的疗效。

Objective : To assess the efficacy of imipramine combined with cognitive-behavioral therapy ( CBT ) in the treatment of depressive patients .

结果氟西汀组有效率92.9%，丙咪嗪组92.6%，经卡方检验P>0.05。

Result The total clinical effective rates were 92.9 % in fluoxetine group and 92.6 % in imipramine group ( P > 0.05 ) .

结论万拉法新治疗老年抑郁症与丙咪嗪疗效相当，但起效较丙咪嗪快，且副作用小。

Conclusion Venlafaxine has a same efficacy to imipramine in the treatment of senile depression , takes effect faster and has fewer side effects .

高剂量阿扑吗啡诱导的小鼠体温下降实验：小鼠分组同上，阳性对照药为盐酸丙咪嗪。

Antagonism of apomorphine-induced hypothermia : Mice grouping was the same as above ; the drug in positive control group was replaced by imipramine .

实验第56天，与抑郁症组相比，酚妥拉明组各指标和丙咪嗪组各指标均明显提高。

On the last day of the experiment , comparing with the depression group , both phentolamine group and imipramine group had significant depressive changes .

结论两药改善一般症状的疗效相近，西沙必利明显改善优势症状；丙咪嗪和西沙必利治疗功能性消化不良的对比研究

Conclusion With regard to the improvement of the general dyspeptic symptoms of dysmotility like FD , the effectiveness of imipramine is equal to cisapride . Comparative study on teatment of functional dyspepsia by imipramine and cisapride

目的：分析三环类抗抑郁药丙咪嗪和单胺氧化酶抑制剂吗氯贝胺治疗抑郁障碍患者的早期反应是否可以预测药物的远期疗效。

Objective : To explore the feasibility to predict the effectiveness of the late stage of anti-depression treatment based on the early stage of the treatment response with imipramine ( tricyclic antidepressant ) and moclobemide ( MAOI antidepressant ) .

结果大鼠海马内新生细胞和神经元的数量损伤组均明显高于未损伤组（P<0.01），而且无论有无脑创伤，丙咪嗪治疗组均高于相应的对照组（P<0.05）。

Results Proliferating cells and neurons were found to be obviously increased in all injured rats compared with sham injured animals ( P < 0.01 ) . Moreover , either in injury or sham group , a substantial neurogenesis was observed in imipramine-treated rats compared with the corresponding controls .