生殖毒性

维生素B6生殖毒性研究

Study on Reproductive Toxicity of VitB_6

轻质油（45℃馏分）蒸气的生殖毒性研究Ⅱ.对大鼠睾丸LDHX及溶酶体酶的影响

Study on reproductive toxicity of light oil vapour ⅱ . effect on LDH-X and lysosomal enzymes of rat testis

本文对荧光涂料激发能源~（147）Pm的生殖毒性进行了研究。

Study on germ toxicity of exciting energy resource 147Pm of fluorescent paint was reported .

ALP和LDHX可作为反映镉雄性生殖毒性较敏感的生化指标。

ALP and LDH X are sensitive biochemical endpoints reflecting cadmium toxicity on male reproductive system .

PAS一Na对染锰雄性大鼠生殖毒性影响的研究

Studies on the effect of PAS-Na on the re-productive toxicity in male rats exposed to manganese

表明在AA生殖毒性中存在着Caspase-3的依赖性凋亡机制。

Show that the existence of caspase-3-dependent mechanism of apoptosis in AA reproductive toxicity . 5 .

性腺是MCs的第2靶器官，有研究证明MCs具有生殖毒性。

Some studies proved MCs may have reproductive toxicity .

补锌在一定程度上能拮抗TNT对大鼠的生殖毒性。

Supplement with zinc had antagonism against male reproductive toxicity induced by TNT .

MTBE及其代谢产物具有一定的遗传毒性和轻微的生殖毒性；

MTBE and its metabolites have some genotoxicity and a little reproductive toxicity ;

PCBs的雄性生殖毒性和内分泌干扰效应已被大量研究证实。

Its reproductive toxicity and endocrine disruption has been confirmed in a large number of researches .

一代生殖毒性实验（1）动物的选择、分组：SD大鼠60只，雌雄各半，随机分为3组。

Generation reproductive toxicity test ( 1 ) Animal selection and grouping : 60 SD rats with half male , divided into 3 groups randomly .

结果表明：在本实验染毒时间和染毒剂量范围内，TDI对雄性的生殖毒性主要表现为对各级生精细胞均有一定的毒性作用，作用的靶点是细胞内的线粒体；

Results showed that TDI induced toxic action on spermatogenic cell , while the chondriosome was its target within the length and concentrations .

对荧光涂料激发能源~（147）Pm的生殖毒性进行了研究，观察到胎盘对~（147）Pm进入子体有明显的屏障作用。

The germ toxicity of exciting energy resource 147Pm of fluorescent paint was studied . It was shown that the placenta was a barrier for 147Pm entering into the fetus .

TDI在小鼠睾丸及附睾中代谢为有毒性的产物，为TDI的生殖毒性提供了依据。

The metabolism of mouse testis and epididymis was toxic , which give the evidences to the toxicity effects of TDI on the reproductive systems .

精子畸形实验有明显剂量反应关系，三氯化铬给药量达到121.8mg／kg时，畸形率有显著性增高，提示三氯化铬具有生殖毒性。

But in the sperm malformation test . the sperm malformation rate significantly increased at the dose of 121.8 mg / kg and it showed a dose response relationship , suggesting that CrCl 3 is toxic to reproductive system .

目的研究吡哆素L2吡咯烷酮5羧酸酯（MTDX）对雄性大鼠生殖毒性作用的机制。

Objective To study the mechanism of male reproductive toxicity of metadoxine ( MTDX ) on mice and rats .

以清洁级ICR小鼠为实验动物，研究化工厂废水中非挥发性物质对小鼠的生殖毒性。

To study the toxicity of non-volatile organic chemicals on reproduction toxicity of male mice , water samples were collected from a chemical plant in Wenzhou .

目的为保证新药轻灵盐酸西布曲明（Qlsibutramine）的临床用药安全，评价其生殖毒性，进行了大鼠致畸试验。

Purpose : To assess the safety of Qingling sibutramine hydrochloride ( Ql sibutramine ) on the reproduction and development of rats .

目的研究1,2-二氯乙烷（1,2-DCE）对小鼠睾丸细胞DNA损伤作用，探讨1,2-DCE的生殖毒性。

Objective To study the effect on DNA damage in the testicle cells of mice exposed to 1,2-dichloroethane and explore reproductive toxicity of 1,2-dichloroethane .

既往关于DEHP的研究主要集中在短期高剂量暴露上，发现DEHP可以诱发肝毒性、睾丸毒性、肾脏毒性、发育障碍和生殖毒性等。

Previous animal studies have demonstrated short-term exposure to high-dosage DEHP induced hepatotoxicity , testicular toxicity , renal toxicity , developmental disturbance , reproductive toxicity , and teratogenicity .

尽管动物实验显示ACR有神经毒性、致肿瘤毒性和生殖毒性，但只有神经毒性是经过职业暴露人群流行病学研究证实的。

Although experimental animal studies have implicated carcinogenicity and reproductive toxicity as possible consequences of ACR exposure , neurotoxicity is the only outcome confirmed by epidemiological studies on occupationally exposed population group .

TCCA可通过降低睾丸内锌、铜的含量，发挥其对睾丸的生殖毒性作用。

TCCA might make the reproductive toxicity to the testis . by means of reducing the contents of Zn and Cu , 6 .

结论除草剂MCPA可抑制雄性小鼠体重增长，并导致内分泌功能紊乱、脾萎缩，具有生殖毒性。

Conclusion MC-PA inhibited the growth of male mice , resulted in endocrine disorder , the atrophy of spleen , and presented the toxicity of repro-ductive system .

目的研究染锰28d与56d小鼠生精功能相关指标的变化，探讨锰生殖毒性的时间-效应关系。

Objective To study on the indexes of 28d and 56d of manganese exposure on spermatogenic function of male mice , and to explore time-effects correlation of manganic toxity .

结论As2O3可通过损伤大鼠睾丸的组织结构、抑制睾丸精子生成而产生生殖毒性。

Conclusion : By means of damaging histological structure changes of testis and restraint of sperm production in male rats , As 2O 3 may give rise to male reproduction toxicity .

DOX-Lip具有一定程度的生殖毒性，临床应用应慎重。

DOX-Lip is considered to have reproductive toxicity in mice . So it should be prudent when it is used in clinical .

有文献报道，DBP、Bap均具有确切的雄性生殖毒性，但两者低剂量联合作用下雄性生殖毒性特别是针对生精细胞的毒性及机制研究尚未见报道。

Previous studies have reported that both DBP and Bap have certain male reproductive toxicity , but the male reproductive toxicity under the exposure to Combination of Bap and DBP , especially for the toxicity of spermatogenic cell and its mechanism .

目的：探讨XAD-2大孔树脂与Waters公司OASISHLB固相小柱在萃取管网末梢水中有机萃取物化学成分及含量的差异，并比较两种有机萃取物对雄性小鼠生殖毒性的影响。

Objective : to explore the differences of chemical composition on drinking water organic extractions by the ( XAD-2 ) macroporous resin and the Waters company Oasis HLB columella , and to compare reproductive toxicity of the two organic extractions in male mice .

药理研究结果显示，具有较强的抗炎作用，和良好的抑制S180小鼠肿瘤生长的作用，延长艾氏腹水型小鼠的生存时间作用明显，急性毒性与生殖毒性均极小。

The pharmacological research results show that , with strong anti-inflammatory effects , and good tumors growth suppression in mice S180 , it can extend the survival time of adenauer ascites type of mice obviously , while acute toxicity and reproductive toxicity are tiny .

目的研究1,2-二甲基-3-羟基-4-吡啶酮（DHPO）的急性毒性及不同剂量、不同时间的生殖毒性。

Objective To evaluate the acute toxicity and reproductive toxicology of deferiprone ( DHPO ) under various doses and during different periods .