细菌生物被膜

食品中细菌生物被膜及其形成机制的研究进展

Research Advance of Bacterial Biofilm and its Formation Mechanism in Food

细菌生物被膜与难治性呼吸道感染

Bacterial biofilm and difficult-to-treat respiratory tract infections

目的探讨鱼腥草对细菌生物被膜的影响，观察鱼腥草与左氧氟沙星联合应用对铜绿假单胞菌（PseudomonasAeruginosa，PA）生物被膜的作用。

Objective To investigate the synergic bactericidal activity of Herba Houttuyniae combined with levofloxacin on the biological envelope of mucoid Pseudomonas aeruginosa ( PA ) .

目的：确定机械通气病人气管内导管（ETT）细菌生物被膜（BF）形成的结构和病原学特征。

Objective : To determine the structural and pathogenic features of endotracheal tube biofilm ( ETT BF ) in patients undergoing mechanical ventilation .

方法：应用藻酸盐-粘液型铜绿假单胞菌接种免疫抑制SD大鼠，制备肺部细菌生物被膜感染病理模型；

Method : The animal model of biofilm associated chronic pulmonary infection was established by inoculating alginate - Pseudomonas aeruginosa to cortisone - treated rats . Biofilm model in vitro was established by the modified plate culture method .

目的：探讨克拉霉素和氟罗沙星对铜绿假单胞菌（PA）生物被膜的影响。方法：选取临床分离的呼吸道PA7株，用平板法培养细菌生物被膜，银染色法鉴定；

OBJECTIVE : To observe the effects of clarithromycin and fleroxacin on Pseudomonas aeruginosa ( PA ) biofilm METHODS : Clinical isolates of 7 strains of PA from respiratory tract were cultured with modified plate culture method ;

目的确定机械通气患者气管内导管（ETT）细菌生物被膜（BF）与长期机械通气反复发作铜绿假单胞菌呼吸机相关肺炎（PAVAP）病原的相关性。

Objective To determine the correlation of endotracheal tube biofilm ( ETT BF ) and recurrent ventilator associated pneumonia with Pseudomonas aeruginosa ( PA VAP ) in long term ventilation patients .

方法采用组织笼（tissuecage）大鼠皮下埋植法建立细菌生物被膜体内局部感染动物模型；微生物法测定病灶局部AZT及FLX的浓度；

METHODS The tissue cage method was used to establish the animal model of local P. aeruginosa biofilm infection and this model was confirmed by using microbiological method , histological method and scanning electronic microscopy ( SEM ) .

细菌生物被膜对抗生素耐药机制的研究进展

Progress on the Mechanisms of Antibiotic Resistance of Bacterial biofilm

克拉霉素对细菌生物被膜作用的研究进展

Progress in Effect of Clarithromycin on Bacterial Biofilm : a Review of the Literature

本文介绍了细菌生物被膜的形成过程和耐药机制，并展望了治疗前景。

Studies of biofilms development , resistance mechanisms and potential for therapies are reviewed .

细菌生物被膜耐药屏蔽与相关感染的治疗

Therapy of bacterial biofilm drug resistant-shield and associated-infection

结论用银染法观察细菌生物被膜的变化可靠、便捷。

Conclusions Silver staining method is reliable and convenient in appraising biofilm of bacteria .

细菌生物被膜及其相关感染的研究进展细菌生物被膜与食品生物危害

Recent progress on bacterial biofilm and related infections Bacterial biofilm and biological hazards of food

细菌生物被膜的耐药机制完全不同于浮游菌，在医院感染中发挥了重要作用。

The complicated drug-resistance mechanism of bioflim bacteria played an important role in the hospital onset of infection .

方法：收集近年有关细菌生物被膜与难治性肺部感染的研究资料并加以归纳综合。

Methods : Collecting and summarizing the related literatures about bacteria biofilm and refractory pneumonia in recent years .

十四元环大环内酯类对细菌生物被膜形成的影响及对环丙沙星的增效作用

Effects of 14 - membered macrolides on the formation of Pseudomonas aeruginosa biofilms and synergism between macrolide and ciprofloxacin

目的通过体外细菌生物被膜模型观察司帕沙星对生物被膜内细菌的清除作用。

Objective : To explore the eradication effect of sparfloxacin SPLX on biofilm bacteria with biofilm models in vitro .

结论：细菌生物被膜的形成与治疗研究对肺部感染的防治有可观的前景。

Conclusions : The formations and treatments studying of bacterial biofilm have bright future in the preventment and treatment of pneumonia .

目的建立体内铜绿假单胞菌生物被膜模型，研究体内细菌生物被膜的组织学及细菌学特征。

Objective To establish an in vivo model of Pseudomonas aeruginosa biofilm in guinea pigs and to investigate its histological and bacteriological features .

由于细菌生物被膜的存在，使被膜内的细菌能够逃逸抗生素的杀伤作用和机体免疫系统的清除，成为潜在的感染源，从而造成感染的反复发作。

Biofilm bacteria could escape the killing effects of antibiotics and organism immune system , and became a potential infection source which resulted to recurrent infection .

方法建立细菌生物被膜，分别用银染法和扫描电镜进行观察生物被膜的变化。

Methods Biofilm of staphylococcus epidermidis was cultured ; silver staining method and scanning electron microscopy were used to observe and appraise the change in the biofilm .

在食品工业中，由于细菌生物被膜独特的微结构及耐药能力，对其防治和消除一直都是食品领域的一大难点。

In the food industry , due to the unique microstructure and resistant ability of biofilm . prevention and elimination of bacteria biofilm formation have always been major difficulty in food processing .

细菌生物被膜引发的感染已成为医院感染的主要原因之一，具有耐药性和难治性的特点，引起了基础和临床研究的极大关注。

The infection caused by bacterial biofilm has becoming one of the most common nosocomial infection and gained much attention recently , with the characteristics of resistant to antibiotics and difficult to be cured .

近些年来，一些研究提示天然产物可以有效的干扰细菌生物被膜的形成，并且避免了消毒剂的残留问题，为有效预防食品加工中生物被膜的形成和散播提供了良好的应用前景。

In recent years , some studies suggest that natural products can effectively decrease the biofilm formation , and avoid the residual of disinfectant , which present desired prospects to prevent biofilm formation effectively in food processing .

目的检测肺炎克雷伯菌、大肠杆菌、铜绿假单胞菌三种细菌的生物被膜（Biofilm，BF）中超广谱β-内酰胺酶（Extended-spectrumβ-lactamases，ESBLs）的产生。

Detection of extended-spectrum β - lactamases in three kinds of bacterial biofilm Objective : To detect the creation of ESBLs from Klebsiella pneumoniae , Escherichia coli and Pseudomonas aeruginosa bacterial biofilm .

司帕沙星对生物被膜内细菌的清除作用细菌生物被膜的研究现状

Study on the eradication effect of sparfloxacin on biofilm bacteria Present Situation of Bacterial Biofilm

本文介绍了具有拮抗细菌耐药性作用的物质的研究进展情况，包括灭活酶抑制剂、药物渗透促进剂、外输泵抑制剂、细菌生物被膜抑制剂、抗菌药物增强剂、耐药质粒消除剂等。

According to the mechanisms of bacterial drug resistance , many antagonists had been developed , including inhibitors of inactive enzymes , accelerators of drug permeation , inhibitors of efflux pump , inhibitors of bacterial biofilm , synergists of antimicrobial and eliminators of resistant plasmid .

要对细菌BF进行研究，首先要建立一个理想的实验模型，体内模型与体外模型相比，更有利于综合考虑内环境因素对细菌生物被膜的影响。

We must establish an ideal model to study the biofilm bacteria . Compared with models in vitro , an in vivo model is beneficial to consider the influence of internal environment .